Stanley Center for the Innovative Treatment of Bipolar Disorder

FIFTH INTERNATIONAL CONFERENCE 
ON BIPOLAR DISORDER



Introduction

Proceedings

Bipolar Conferences Home

Biographical Sketches of Course Directors and Presenting Faculty (A - L)

HAGOP S. AKISKAL, M.D.
Professor of Psychiatry
Director, International Mood Center
University of California at San Diego
San Diego, California

Prior to his present post, Dr. Akiskal served as Senior Science Advisor to the Director of the National Institute of Mental Health (1990-1994). Earlier he was at the University of Tennessee, Memphis, where he established Mood Clinics which have had worldwide appeal because of their philosophy of conducting clinical training and research while delivering high quality care. Dr. Akiskal’s studies examine the relationship of subclinical temperament traits and various affective disorders, with special focus on the soft bipolar spectrum. He has contributed over 300 papers to the scientific literature and authored or edited ten books, the latest of which is Dysthymia and the Spectrum of Chronic Depressions (Guilford Press, 1997). Dr. Akiskal has won numerous national and international awards, including the Gold Medal for “Pioneer Work” from the Society of Biological Psychiatry (1995), the Anna Monika German Prize for research on depression, the NARSAD Affective Disorder Prize for his work on the bipolar spectrum, the Jean Delay Prize of the World Psychiatric Association, as well as the first Aretaeus Prize (Rome).


JULES ANGST, M.D.
Emeritus Professor of Psychiatry
The University of Zurich
Epidemologic Research
Zurich University Psychiatric Hospital

Jules Angst, M.D., is Emeritus Professor of Psychiatry at Zurich University in Zurich, Switzerland, and Honorary Doctor of Heidelberg University in Heidelberg, Germany. He was Professor of Clinical Psychiatry and Head of the Research Department of Zurich University Psychiatric Hospital (the Burghölzli) from 1969 to 1994. He has received many awards in recognition of his work, including the Anna Monika Awards (1967/1969), Paul Martini Prize for Methodology in Medicine (1969), Otto Naegeli Prize (1983), Eric Strömgren Medal (1987), and the Emil Kraepelin Medal of the Max Planck Institute, Munich (1992). He has also received the Selo Prize NARSAD/Depression Research, USA (1994), Mogens Schou Award for Research in Bipolar Disorder, USA

(2001), the Burghölzli Award for Social Psychiatry (2001) and the Lifetime Achievement Award of the International Society of Psychiatric Genetics (2002).


DAVID AXELSON, M.D.
Assistant Professor of Psychiatry
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Dr. Axelson received a B.A. in 1987 from Brown University and his M.D. in 1992 from the Duke University School of Medicine. He completed a combined General – Child Psychiatry residency at Western Psychiatric Institute and Clinic in 1997 and a post-doctoral research fellowship in child and adolescent mood disorders at the University of Pittsburgh. Dr. Axelson has been on the faculty at the University of Pittsburgh Medical School, in the Department of Psychiatry since 2000, when he was named the Director of the Child and Adolescent Bipolar Services (CABS) clinic at Western Psychiatric Institute and Clinic. Through his work at the CABS clinic, he has the opportunity to take care of many children and adolescents with bipolar disorder.

Dr. Axelson’s research interests include pediatric bipolar disorder, metabolism of psychiatric medications in the pediatric population, the neurobiological basis of mood disorders and medication treatment of mood disorders in children and adolescents. He has been the recipient of a Research Career Development Award from the National Institutes of Mental Health (NIMH). Dr. Axelson has completed studies that examine the metabolism of selective serotonin reuptake inhibitors in adolescents. He is the principal investigator at the Pittsburgh sites of a medication treatment trial of early-onset bipolar disorder and a family-focused psychotherapy study in bipolar adolescents. He is also involved in several studies examining the phenomenology of bipolar disorder in youth.


MARK S. BAUER, M.D.
Acting Chief of Staff and
Chief, Mental Health and Behavioral Sciences Service
Providence VA Medical Center
Associate Professor of Psychiatry
Brown University of Medicine
Providence, Rhode Island

Dr. Bauer received his B.A. from the University of Chicago and his M.D. from the University of Pennsylvania. He is currently Associate Professor of Psychiatry at Brown University and on staff at the Providence (RI) Veterans Affairs Medical Center.

Dr. Bauer has served as Principal Investigator on federal grants each year since residency and has received awards for research, teaching, administration, and clinical care including twice being named Exemplary Psychiatrist by the National Alliance for the Mentally Ill.

Dr. Bauer’s scientific contributions have included use of high dose thyroid hormone treatment for rapid cycling manic-depressive disorder, as well as assessment, phenomenology, and course in manic-depressive disorder. For the last 10 years his focus has been on developing and testing methods to improve treatment delivery for manic-depressive disorder, particularly using collaborative practice approaches.

He is the author of two recent books on the assessment and treatment of major mental illnesses: The Field Guide to Psychiatric Assessment and Treatment (Philadelphia, Lippincott, 2003) and Structured Group Psychotherapy for Bipolar Disorder: The Life Goals Program, 2nd Edition, (New York, Springer, 2003).


MICHAEL BERK, M.D., Ph.D.
Associate Professor
University of Melbourne
Victoria, Australia

Professor Michael Berk is currently appointed to the Chair of Psychiatry for Barwon Health and The Geelong Clinic at The University of Melbourne.

He has published approximately 90 papers in peer reviewed journals and presented extensively on a wide range of topics with his research interests focusing on mood and psychotic disorders, particularly bipolar disorder. He has published a number of self-initiated randomized controlled trials in bipolar disorder and has established the Mood and Anxiety Disorders Unit at Barwon Health. He chairs the University of Melbourne Bipolar Special Interest Group and the Melbourne Academic Consortium Clinical Research and Clinical Trials Domain and is the principal investigator on a number of current trials. He is a member of a number of international advisory boards and is on the editorial board of four journals.


WADE H. BERRETTINI M.D., Ph.D.
Karl E. Rickels Professor of Psychiatry
Director, Center for Neurobiology and Behavior
University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania

Dr. Berrettini is the Karl E. Rickels Chair of Psychiatry and Director of the Center for Neurobiology and Behavior, at the University of Pennsylvania. He received an MD from Jefferson Medical College and a PhD in pharmacology from Thomas Jefferson University. Dr. Berrettini performed his residency in psychiatry in the Department of Psychiatry and Human Behavior at Thomas Jefferson University. He has received numerous awards, including the National Alliance for Research on Schizophrenia and Depression Established and Distinguished Investigator Awards; the Selo Prize, National Alliance for Research on Schizophrenia and Depression; the Louis Lurie Memorial Lecture Award, University of Cincinnati College of Medicine; and the H. J. Weitbrecht Scientific Award, University of Bonn, Bonn, Germany. Dr. Berrettini is a member of numerous professional societies and an editor for major scientific journals such as Psychiatric Genetics, Molecular Psychiatry, Neuropsycho-pharmacology, Biological Psychiatry, and the American Journal of Medical Genetics. He has authored over 150 peer-reviewed papers, and contributed to numerous book chapters, conference publications, and case reports. Dr. Berrettini is one of the world's authorities on genetic susceptibility to bipolar disorder. His group has several projects designed to identify susceptibility genes for common behavioral disorders, including bipolar disorder, idiopathic epilepsy, schizophrenia, anorexia nervosa and heroin dependence. In the genetic studies of bipolar disorder and schizophrenia, a region of chromosome 18 is being investigated for DNA sequence variations which are associated with increased risk for illness.


BORIS BIRMAHER, M.D.
Professor of Psychiatry
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Boris Birmaher, M.D. is a Professor of Psychiatry with board certifications in both general psychiatry and child psychiatry. He received his medical degree from Valle University in Cali, Colombia and his general psychiatry degree from the Hebrew University, Hadassah Medical Center in Jerusalem, Israel. He received his training in biological psychiatry at the Albert Einstein College of Medicine in New York and training in child psychiatry at Columbia University, New York Psychiatric Institute in New York.

Dr. Birmaher is the Director of the Child and Adolescent Anxiety Program and Co-Director of the Child and Adolescent Bipolar Services at Western Psychiatric Institute and Clinic. He is a well-known researcher in pharmacological and biological studies of children and adolescents with mood and anxiety disorders and he has published many articles in this area. Currently, Dr. Birmaher has several research grants studying the course and outcome of bipolar youth, the manifestations of bipolar disorder in offspring of bipolar parents, and the treatment of children and adolescents with bipolar, major depression and anxiety disorders. In addition Dr. Birmaher is the recipient of an endowment from the University of Pittsburgh, School of Medicine to study the early onset of bipolar disease.


CHARLES L. BOWDEN, M.D.
Karren Professor and Chairman
Department of Psychiatry
The University of Texas Health Science Center at San Antonio
San Antonio, Texas

Dr. Charles Bowden is Chairman of the Department of Psychiatry at The University of Texas Health Science Center at San Antonio. Dr. Bowden received his training in Psychiatry at the New York State Psychiatric Institute and Presbyterian Hospital in New York. He is professor both in the departments of psychiatry and pharmacology and holds the Nancy U. Karren Chair of Psychiatry. He is a member of the Scientific Advisory Board of the National Depressive and Manic-Depressive Association and in 2001 received the Gerald L. Klerman Senior Investigator Award of the Association. He is a Fellow of the American College of Neuropsychopharmacology, the Collegium Internationale Neuro-Psychopharmacologicum, and the American College of Psychiatrists, Corresponding Member of the European College of Neuropsychopharmacology (ECNP), a member of the editorial boards of Bipolar Disorders, Acta Psychiatrica Scandinavica, Journal of Bipolar Disorders and Depression and Anxiety. He is Co-Chairman of the World Federation of Biological Psychiatry Guidelines for biologic Treatment of Bipolar Depression. He is a reviewer for several journals including the Archives of General Psychiatry, Biological Psychiatry and the Journal of the American Medical Association. He is author of over 220 publications. His research is principally on the symptomatic and biological characterization of bipolar disorders, and the efficacy and pharmacodynamics of mood stabilizing drugs. He has been principal investigator for 64 studies funded by pharmaceutical companies, NIMH, and foundations. He frequently serves as consultant to pharmaceutical companies and governmental agencies and is named in Best Doctors in the U.S. in the area of mood disorders.


CHARLOTTE BROWN, Ph.D.
Assistant Professor of Psychiatry
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Charlotte Brown is Assistant Professor of Psychiatry and Director of the Health and Behavior Studies Program at the University of Pittsburgh School of Medicine. She received her Bachelor of Arts degree, cum laude, from Boston University; Master of Science degree from Howard University; and Ph.D. from The American University in Washington D.C. Dr. Brown completed her clinical training at McLean Hospital, Harvard Medical School, and Post-doctoral training at the Western Psychiatric Institute and Clinic.

Dr. Brown’s research and clinical interests involving the interface of physical health and psychological well-being have led her to focus on the recognition and treatment of depression in primary care patients. She is former recipient of a NIMH Scientist Development Award, and is currently the Principal Investigator of the NIMH-funded study “Improving Primary Care Services: Personal Illness Models.” This four year project will examine the impact of patient attitudes and beliefs about the nature of depression on antidepressant adherence and illness management strategies. Dr. Brown is also a co-investigator in the recently funded “Commonwealth Center of Excellence for Bipolar Disorder” (PI: DJ Kupfer).

Other research interests include: psychosocial factors affecting women’s health; the impact of race and ethnicity on depression recognition and management; and the influence of anxiety on depression course and outcomes. Her most recent publications involve research in the primary care sector and include: the effect of anxiety on depression treatment outcomes, racial differences in the clinical presentation and treatment outcomes for major depression, and primary care patients’ personal illness models for depression.

Dr. Brown is also active in community initiated activities to increase public awareness of depression and available treatments, particularly in African American communities.


JOSEPH R. CALABRESE, M.D.
Department of Psychiatry
Case Western Reserve University School of Medicine
Cleveland, Ohio

Dr. Calabrese completed his medical training at the Ohio State University School of Medicine and his psychiatric residency at the Cleveland Clinic Foundation. After completing a research fellowship in Clinical Neuroendocrinology at the National Institute of Mental Health, he returned to Cleveland in 1989 to start the Mood Disorders Program. Dr. Calabrese has been chosen by the psychiatric residents to receive the Best Teacher of the Year Award during three different years. He is currently Professor of Psychiatry at Case Western Reserve University, the Director of the Mood Disorders Program University Hospitals of Cleveland, and Co-Director of the Stanley Medical Research Institute Bipolar Disorders Clinical Research Center. Dr. Calabrese has over 180 publications that focus on the development of the class of anticonvulsants as mood stabilizers for use in the treatment of rapid-cycling bipolar disorder. Dr. Calabrese has received four research grants from the NIMH, and these have all focused on the development of new treatments for bipolar disorder with particular emphasis on rapid cycling bipolar disorder. More recently, and with Robert Findling, MD as co-principal investigator, he has received a fifth grant from the NIMH (P20) to support the development of a clinical research center dedicated to the treatment of bipolar disorder across the life span. This center will focus on improving clinical outcomes in underserved populations of bipolar disorder, including those receiving care within community mental health centers, children and adolescents, and adults currently abusing alcohol and/or drugs.


DONNA J. CAROTHERS
Executive Director
International Society for Bipolar Disorders (ISBD)
Pittsburgh, Pennsylvania

Ms. Carothers received her training in business and communications at Carlow College. She has served as the Executive Director of the International Society of Bipolar Disorders since its founding in 2000. Under her direction, the organization has grown from a membership of 100 to a membership of over 700 representing 28 countries on all 5 continents.

Prior to this position, Ms. Carothers served as the assistant director of administration at the Hospice and Palliative Nurses Association (HPNA), a national organization, and their sister organization, the National Board for Certification of Hospice and Palliative Nurses (NBCHPN). During her tenure in this position, the organization grew to over 3,000 members and became the first to provide Board Certification to a member of the palliative care clinical team.

Ms. Carothers has been the interim director of the Children’s Health Network, at the Children’s Hospital of Pittsburgh. In this role, she was responsible for providing guidance and direction to academic faculty, community physicians and hospital administrators to create a Physician-Hospital Organization with the ability to act as a contractual vehicle for pediatric managed care services.

Ms. Carothers created the ISBD Global, the official newsletter of the International Society of Bipolar Disorders and is the managing editor. She is currently a member of the Pittsburgh Society of Association Executives and co-chairs the Palliative Care Steering Committee at Children’s Hospital of Pittsburgh. Ms. Carothers also serves as a member of the Pittsburgh Regional Healthcare Initiative (PRHI) Depression Subcommittee.

Ms. Carothers also serves as a consultant to LEAD Pittsburgh, a community-based initiative to educate and raise awareness of depressive disorders.


GIOVANNI B. CASSANO, M.D.
Professor of Psychiatry
Universita Degli Studi di Pisa
Pisa, Italy

Giovanni Battista Cassano is Full Professor of Psychiatry, Institute of Psychiatry, University of Pisa, Italy, and since 2001 Director of the Department of Psychiatry, Neurology, Pharmacology and Biology of the University of Pisa. He is fellow of The Royal College of Psychiatrists, London, member of the American Psychopathological Association and of Geselleschaft Osterreichischer Nervenarzte und Psychiater. He was founder of ECNP and of the International Committee for Prevention and Treatment of Depression. He is a foreign corresponding member of The American College of Neuropsychopharmacology and a member of the Editorial Board of the “Bipolar Disorders: An International Journal of Psychiatry and Neurosciences”. His scientific background moves from a basic psychopharmacology broadening to clinical psychopharmacology, with special regard to the methodological aspects in conducting and documenting clinical trials with psychoactive drugs. Thanks to his contribution in this area, he obtained a NIMH grant from 1980 to 1986. He conducted and coordinated a large number of clinical studies testing the efficacy and safety of antidepressants, anxiolitics, antipsychotics and mood stabilizers. He is dedicated to research in different psychopathological and clinical fields, focusing on the problems of diagnosis, classification and short-term/long-term treatment especially of mood disorders and anxiety disorders. In these last years, he led an international (Pisa-Pittsburgh-Washington) group of clinical researchers working on the study of subclinical, soft, atypical manifestations of bipolar disorders, anxiety and eating disorders. Professor Cassano is the author of over 500 scientific publications. Moreover he is co-author of a best-selling book for the Italian public. Professor Cassano is the Director of the Institute of Psychiatry of the University of Pisa, where he is leading a group of researchers and clinicians who have combined expertise both in academic and clinical psychiatry advancing our understanding of the ‘spectrum’ concept in mood, anxiety and eating disorders.


PAULA J. CLAYTON, M.D.
Clinical Professor of Psychiatry
University of New Mexico School of Medicine
Professor Emeritus
University of Minnesota Medical School
Santa Fe, New Mexico

Dr. Clayton graduated from the University of Michigan in 1956 with a Bachelor of Science degree. In 1960, she graduated AOA from Washington University School of Medicine in St. Louis, Missouri. She did her psychiatric residency there and joined the staff in 1965. She progressed from instructor, to assistant, to associate, and finally to full professor in 1976. In September of 1980, she was appointed Professor and the Head of the Department of Psychiatry at the University of Minnesota School of Medicine where she served until her retirement in 1999. She is a professor Emeritus there. Her first paper, in 1965, defined mania. In 1969, she published, with Drs. Winokur and Reich, the first textbook on mania entitled Manic Depressive Illness. She published three additional books, more than 150 papers and 20 book chapters. Her areas of expertise and research are mood disorders, particularly bipolar and unipolar illness, and bereavement. She is still active in research in these areas.

She is a member of many editorial boards, psychiatric societies, has served on study sections and has been on many other governmental and nongovernmental committees. In 1985, she received the Athena Award from the University of Michigan as the outstanding woman alumna of the year. She also received a Distinguished Alumnae Award from Washington University in 1985 and in 1993, the First Aphrodite Jannapaula Hofsommer Award from Washington University.

When she was appointed to the Chair at the University of MN School of Medicine, she was the first woman chair of a department of psychiatry in the country and the first woman chair in the medical school in MN. She served for almost 20 years. During that time, the first 3rd year psychiatry clerkship began, grand rounds became a weekly affair featuring clinical cases and noted speakers, the department research budget grew from about $300,000 to $15,000,000, two endowed chairs and two professorships were funded, multiple named lectures were begun, and finally, the department received generous and well appointed new space for it's outpatient clinical services and offices. At the same time the inpatient space was expanded for adult and child services and substance abuse care.

She is currently a Professor of Psychiatry at the University of New Mexico School of Medicine where she teaches at the psychiatric outpatient clinic.


ELLEN FRANK, Ph.D.
Professor of Psychiatry and Psychology
University of Pittsburgh School of Medicine
Director, Depression and Manic Depression Prevention Program
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Dr. Ellen Frank is Professor of Psychiatry and Psychology at the University of Pittsburgh School of Medicine and Director of the Depression and Manic Depression Prevention Program at Western Psychiatric Institute and Clinic. She graduated from Vassar College in 1966 and received a masters’ degree in English from Carnegie Mellon University in 1967. Her doctoral work in psychology was done at the University of Pittsburgh and completed in 1979.

Under a MERIT Award grant from the National Institute of Mental Health, Dr. Frank is currently studying the efficacy of Interpersonal and Social Rhythm Therapy, a psychotherapy she and her colleagues developed for the adjunctive treatment of manic-depressive illness. She recently completed an NIMH-sponsored study of women with recurrent depression in which she examined how psychobiology, life stress, and different “doses” of psychotherapy interact to increase or decrease vulnerability to new episodes of depression. In addition, Dr. Frank is currently involved in a joint project with researchers at the University of Pisa, Italy aimed at achieving a better understanding of the clinical importance of subsyndromal mood, anxiety and eating disorders.

An expert in mood disorders and their treatment, Dr. Frank was a member of the American Psychiatric Association Task Force on DSM-IV and was Chair of the Food and Drug Administration Psychopharmacologic Drugs Advisory Panel. Dr. Frank is also a former member of the National Advisory Mental Health Council and the National Institutes of Health Panel on Scientific Boundaries for Review. She is an Honorary Fellow of the American Psychiatric Association. In 1999, Dr. Frank was elected to the National Academy of Sciences Institute of Medicine.


JOHN GEDDES, M.D., FRCPsych.
Professor of Epidemiological Psychiatry
Department of Psychiatry
University of Oxford
Oxford, United Kingdom

Professor Geddes received his medical training in the UK at Leeds University. He trained in psychiatry in Sheffield, Edinburgh and Oxford. Since 1995, he has worked in the Department of Psychiatry at the University of Oxford. He was made professor in 2002.

Professor Geddes has conducted both observational and interventional epidemiological research into depression, schizophrenia and bipolar disorder as well as several other conditions. His current research focuses on conducting large scale randomized clinical trials and using the results of systematic overviews and meta-analysis to inform clinical practice.

Professor Geddes continues to run a busy clinical practice, specializing on the treatments of patients with mood disorders.


VALENTIM GENTIL, M.D., Ph.D.
Professor of Psychiatry
University of São Paulo Medical School
Chairman, Institute of Psychiatry
Hospital das Clínicas
São Paulo, Brazil

Dr. Gentil completed his medical studies and residency in Psychiatry at the Department and Institute of Psychiatry in São Paulo. He then was a post-graduate student at the Institute of Psychiatry and Maudsley Hospital in London, UK, where he obtained his PhD in Clinical Psychopharmacology under the supervision of Prof.Malcolm Lader. Back to Brazil, Dr.Gentil was assistant and then associate professor in the Departments of Pharmacology (until 1987) and Psychiatry (1986-current) of the University of São Paulo (USP). His teaching, clinical and research activities include work in the areas of diagnosis, treatment and psychophysiology of mood and affective disorders. He was Head of the Department of Psychiatry in 1992-96, and since 1994 he is Professor and Chairman of the Institute of Psychiatry, a 200 bed academic psychiatric facility within the 2000 bed medical centre of the USP Medical School. His current projects include a collaborative investigation of the psychobiological mechanisms of emotional regulation and appetite/weight control under antidepressants, and the development of an efficient programme for bipolar disorder prevention. He has published more than 65 articles in peer-reviewed journals, and is a member of the editorial boards of Bipolar Disorder, Molecular Psychiatry, Journal of Psychopharmacology, and Stress & Health, among others. Besides his academic and clinical activities, Dr. Gentil serves in the advisory board of ABRATA - Brazilian Association of Affective Disorders - a non-professional organization.


SAMUEL GERSHON, M.D.
Emeritus Professor of Psychiatry
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Dr. Samuel Gershon joined the faculty at the University of Pittsburgh in April 1988, as Associate Vice Chancellor for Research in the Health Sciences, and Associate Research Director for the Neurosciences in the Department of Psychiatry. He stepped down from this position in 1995 and assumed the position of Chairman of the University of Pittsburgh, Institutional Review Board. Prior to his tenure with the University of Pittsburgh, Dr. Gershon held the positions of Professor and Chairman of the Department of Psychiatry at Wayne State University and was also the Director of the Lafayette Clinic. Dr. Gershon’s career as a psychiatrist and investigator spans more that 45 years. During this time he has published more than 600 writings and has won several prestigious awards including, among others, the Pfizer Scholarship for Medical Research Overseas and the American Psychiatric Association’s Rush Gold Medal Award. His area of specific interest and work encompasses psychopharmacological interest in various psychiatric areas. He is currently the Co-Editor of Bipolar Disorders – An International Journal of Psychiatry and Neurosciences and has been since its inception in 1998. He is also a founding Councilor of the International Society for Bipolar Disorders and was elected as President in 2001.


GIOVANNI DE GIROLAMO, M.D.
Department of Mental Health
Bologna
Consultant
National Institute of Health
National Mental Health Project
Rome, Italy

Giovanni de Girolamo currently works at the Department of Mental Health in Bologna (Italy). He has a Degree in Medicine and a Postgraduate Degree in Psychiatry (University of Naples).

He has worked as clinical psychiatrist in various facilities in Italy, and has been involved in a variety of research projects in Italy and elsewhere. He has received Fellowships to spend some time at the Institute of Psychiatry in London (with Michael Shepherd, one of the fathers of psychiatric epidemiology), at the Institute of Psychiatric Demography in Aarhus (Denmark), and, more recently, at the Western Psychiatric Institute and Clinic in Pittsburgh, USA. He has been the Director of the Italian Collaborating Centre involved in the WHO Quality of Life Project (WHOQOL).

From 1988 to 1994, he worked at the Division of Mental Health of WHO in Geneva, initially as Associate Professional Officer and then as Medical Officer, under the guidance of Norman Sartorius. From 1998 to 2001 he was the Director of the National Mental Health Project, based at the Italian National Institute of Health in Rome, which involved 27 specific research projects and more than 100 centres throughout Italy. Among these projects there is the survey of all non-hospital residential facilities hosting psychiatric patients in Italy (the largest survey ever done in this area).

He has had several teaching appointments in Italy, and has organized several national and international meetings. His research focuses on the epidemiology of schizophrenia, PTSD, and personality disorders; evidence-based medicine applied to psychiatry; drug-utilization studies; psychiatric rehabilitation; and quality of life. He has edited or authored more than 25 volumes or monographs, some 100 papers and 35 book chapters in 3 languages.


JOSEPH F. GOLDBERG, M.D.
Research Scientist
Zucker Hillside Hospital
North Shore Long Island Jewish Health System
Glen Oaks, New York

Dr. Goldberg is currently a Research Scientist in the Department of Psychiatry at the Zucker Hillside Hospital of the North Shore/Long Island Jewish Health System. He attended college at the University of Chicago and obtained a master’s degree in neuroscience from the University of Illinois before attending medical school at Northwestern University. Thereafter, he completed his psychiatry residency, Chief Residency, and research fellowship in psychopharmacology at the Payne Whitney Clinic of New York Presbyterian Hospital. After joining the faculty there in 1997 he founded the Cornell Bipolar Disorders Research Program which he directed until moving to Zucker Hillside Hospital in 2003. He also was Principal Investigator at the Cornell site of the NIMH Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) from 1999-2003. Dr. Goldberg’s research focuses on the pharmacotherapy, course, pharmacogenetics, and outcome of bipolar disorder. He is the recipient of an NIMH Career Development Award, an NIMH New Investigator Award, a 2-time recipient of a NARSAD Young Investigator Award, and an associate member of the American College of Neuropsychopharmacology. He has published one book and over 40 articles on the phenomenology and treatment of bipolar disorder.


GUY GOODWIN, M.D.
W. A. Handley Professor of Psychiatry Chairman of University Department Warneford Hospital Oxford
United Kingdom

Dr. Goodwin trained in medicine and completed a DPhil in physiology at Oxford. After training in psychiatry he spent 10 years as Clinical Scientist and Consultant Psychiatrist in the Medical Research Council (MRC) Brain Metabolism Unit in Edinburgh, Scotland. He has served as a member on the Wellcome Trust Neurosciences Panel, the Council of the British Association for Psychopharmacology and the Clinical Fellowships Panel and Advisory Board of the MRC. He is currently president of the British Association for Psychopharmacology. Dr. Goodwin has published more than 200 refereed papers and book chapters.

Dr. Goodwin has been W. A. Handley Professor of Psychiatry at the University of Oxford, Oxford, UK since 1996. His research interests are in the neurobiology and treatment of mood disorder. He has helped develop the basis for a large-scale pragmatic clinical trial in bipolar affective disorder, BALANCE.


MARTHA HELLANDER
Executive Director
Child and Adolescent Bipolar Foundation
Wilmette, Illinois

Martha Hellander, J.D., of Wilmette, Illinois is executive director and webmaster of the Child & Adolescent Bipolar Foundation (CABF), a Web-based, not-for-profit organization of over 10,000 families raising children diagnosed with, or at risk for, bipolar disorder. She founded an on-line parent support group on Compuserve in 1996 that merged with BPParents, another online group, in 1997. In 1999, she convened and chaired (entirely on-line) the national steering committee that founded CABF with an initial group of 200 families.

CABF's interactive web site, www.bpkids.org, is a virtual community center with over twenty on-line support groups (including several in countries outside the U.S.), 17 message boards, a global database of professionals, a Learning Center with numerous full-text medical journal articles, a gallery of children's art, and more. The site was named a Peter F. Drucker Nonprofit Innovation Web site in 2002. It serves over 4 million hits per month and has been visited by people from over 50 countries.

CABF publishes a bi-monthly electronic newsletter, the e-Bulletin, distributed free to over 14,000 subscribers by e-mail. It contains in-depth articles on pediatric bipolar disorder, stories of children and families, legislative news, and interviews with leading researchers about their work.

Martha Hellander is a graduate of the University of Minnesota (B.A. Economics 1975) and University of Minnesota School of Law (J.D. 1978) and practiced family law and appellate law in Minnesota and Chicago from 1978-l988. She is also an award-winning writer (Parenting Publications of America Best Feature Award 1992, Minnesota Book Award 1993).


THOMAS R. INSEL, M.D.
Director, National Institute of Mental Health
Bethesda, Maryland

Thomas R. Insel, M.D., is Director of the National Institute of Mental Health (NIMH), the component of the National Institutes of Health charged with generating the knowledge needed to understand, treat, and prevent mental disorders that affect an estimated 44 million Americans, including one in five children. Dr. Insel sees as priorities for NIMH the discovery of susceptibility genes and diagnostic biomarkers for the major mental disorders; research that will lead to a reduction in suicide, which today is globally responsible for as many deaths as wars and homicides combined; enhanced behavioral strategies for reducing HIV/AIDS transmission; and elucidating causal risk processes that will enable prevention of mental disorders.

Immediately prior to his appointment as Director, which marks his return to NIMH after an 8-year hiatus, Dr. Insel was Professor of Psychiatry at Emory University. There, he was founding director of the Center for Behavioral Neuroscience, one of the largest science and technology centers funded by the National Science Foundation and, concurrently, Director of an NIH-funded Center for Autism Research. From 1994 to 1999, he was Director of the Yerkes Regional Primate Research Center in Atlanta. While at Emory, Dr. Insel continued the line of research he had initiated at NIMH studying the neurobiology of complex social behaviors in animals. A particular focus of his work has examined the role of the neuropeptides oxytocin and vasopressin in social attachment – including, for example, maternal behavior and pair-bond formation – and in aggressive behavior. This work established his place on the ISI’s list of the 200 most frequently cited neuroscientists in the 1990s. Early in his NIMH research career, which extended from 1979 to 1994, Dr. Insel conducted clinical research on obsessive-compulsive disorder, conducting some of the first treatment trials for OCD using the selective serotonin reuptake inhibitors (SSRI) class of medications.

Dr. Insel serves on numerous academic, scientific, and professional committees, including 10 editorial boards. He is a fellow of the American College of Neuropsychopharmacology, and has is a recipient of the A. E. Bennett Award from the Society for Biological Psychiatry, In 1991, he was recipient of the prestigious Curt Richter Prize for his studies of the neurobiology of attachment. Additional awards have been granted by the Public Health Service and the National Alliance for Research on Schizophrenia and Depression (NARSAD). Dr. Insel graduated from the combined B.A.-M.D. program at Boston University in 1974. He did his internship at Berkshire Medical Center, Pittsfield, Massachusetts, and his residency at the Langley Porter Neuropsychiatric Institute at the University of California, San Francisco.


PAUL E. KECK, JR., M.D.
Professor and Vice Chairman for Research
Department of Psychiatry
University of Cincinnati college of Medicine
Cincinnati, Ohio

Paul E. Keck, Jr., MD, is Professor of Psychiatry, Pharmacology and Neuroscience, and Vice Chairman for Research, Department of Psychiatry, University of Cincinnati College of Medicine. Dr. Keck is also Chief, Division of Clinical Neuroscience, affiliated with the University of Cincinnati Medical Center, and Associate Director of the General Clinical Research Center, Cincinnati Veterans Affairs Medical Center. Dr. Keck’s program conducts research regarding the nosology, biology, course of illness, genetics, and treatment of bipolar disorder. In addition, the Division is a center for the study of new medicines to treat mood, anxiety, psychotic, eating, and impulse control disorders.

A graduate of Dartmouth College, Dr. Keck received his M.D. from the Mount Sinai School of Medicine, New York, NY. He served his internship in Internal Medicine at the Beth Israel Medical Center in New York and completed his residency training in Psychiatry at McLean Hospital, Belmont, MA. Dr. Keck remained on faculty at McLean and Harvard Medical School before joining the faculty at the University of Cincinnati in 1991.

Dr. Keck is the author of over 385 scientific papers and abstracts in leading medical journals. He has also contributed over 110 reviews and chapters to major psychiatric textbooks. Dr. Keck is the editor of the book Managing Depressive Symptoms in Schizophrenia and co-author of The Neuroleptic Malignant Syndrome and Related Conditions (2nd ed.). He serves on the editorial boards of 6 journals and is Deputy Editor of Current Psychiatry. He also served on the American Psychiatric Association’s Workgroup to Develop Practice Guidelines for Treatment of Patients with Bipolar Disorders (1994 and 2001) and currently serves on the APA Institute for Research and Education. Dr. Keck is currently a member of the FDA Psychopharmacologic Drug Advisory Committee.

Dr. Keck is the recipient of numerous honors, including the Gerald Klerman Young Investigator Award from the National Depressive and Manic-Depressive Association (NDMDA); the Exemplary Psychiatrist Award from the National Alliance of the Mentally Ill (NAMI); the Philip Isenberg Teaching Award from Harvard Medical School; the Nancy C A Roeske Certificate for medical student education from the American Psychiatric Association; the Wyeth-Ayerst AADPRT Mentorship Award; two Communicator Awards for Continuing Medical Education; the Outstanding Physician Partner Award of the Postgraduate Institute for Medicine; and two Golden Apple Teaching Awards from the University of Cincinnati College of Medicine.

He is listed as one of the Best Doctors in Cincinnati by Cincinnati Magazine; The Best Doctors in America, a directory of the top one percent of physicians in the United States as rated by their peers; and as one of the nation’s Best Mental Health Experts by Good Housekeeping Magazine. Dr. Keck is also the Director of Scientific Development for the Neuroleptic Malignant Syndrome Information Service (NMSIS).


ATHANASIOS KOUKOPOULOS, M.D.
Director
Centro Lucio Bini
Rome, Italy

Director of the Centro Lucio Bini, a center for the treatment and study of psychiatric conditions, particularly affective disorders, that he and other colleagues founded in 1970. In 1977, he founded the Centro Lucio Bini in Cagliari with Dr. Leonardo Tondo. From 1963 to 1998 he was the Head of the medical staff of the Clinica Belvedere Montello, a private psychiatric in-patient facility in Rome.

His main activity is the examination and treatment of psychiatric patients with a particular interest in Affective Disorders. In addition to his clinical activity, he has been performing clinical research on the course of Manic-Depressive Illness and the pattern of the manic-depressive cycle.

He is also conducting studies on manic-depressive temperament and its importance in the genesis of affective disorders and their course.

Related to the above issues have been other lines of research such as the response to prophylactic lithium treatment and the increase of bipolarity and frequency of recurrences following antidepressant drug treatments. The role of temperament, the previous course of illness, the study of agitated depression as a mixed state, as well as the concomitant factors, course and treatment of rapid cyclicity have been the central focus of his work.


DAVID J. KUPFER, M.D.
Thomas Detre Professor and Chairman
Department of Psychiatry
Professor of Neuroscience
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

David J. Kupfer, M.D., Thomas Detre Professor and Chairman of the Department of Psychiatry and Professor of Neuroscience at the University of Pittsburgh School of Medicine, received his bachelor (magna cum laude) and M.D. degrees from Yale University. Following completion of an internship, Dr. Kupfer continued his postgraduate clinical and research training at the Yale New Haven Hospital and at the National Institute of Mental Health (NIMH). In 1969, he was appointed an assistant professor of psychiatry at Yale University School of Medicine. Dr. Kupfer joined the faculty at the University of Pittsburgh in 1973 as an associate professor of psychiatry and director of research and research training at Western Psychiatric Institute and Clinic. He was promoted to professor of psychiatry in 1975 and became chairman of the department in 1983. As Thomas Detre Professor and Chairman of the Department of Psychiatry and Director of Research at WPIC, he oversees the coordination and expansion of investigations among the department's almost 200 faculty. He has promoted widespread collaborations between clinical investigators in psychiatry and those in more basic neurosciences. These studies are not limited to depression and other mood disorders but encompass virtually every psychiatric disorder and every age group, from infants to the "oldest old." Under Dr. Kupfer's direction, WPIC has become one of the nation's preeminent university-based psychiatric centers as evidenced by the quality and number of publications as well as the amount of peer-reviewed federal funding for mental health research.

For more than twenty years, Dr. Kupfer's research has focused primarily on the conceptualization, diagnosis, and treatment of mood disorders. He has written more than 835 articles, books, and book chapters that examine the use of medication in recurrent depression, the causes of depression, and the relationship between biomarkers and depression.

In recognition of his contributions to the field, Dr. Kupfer has been the recipient of numerous awards and honors including the A.E. Bennett Research Award in Clinical Science (1975), the Anna-Monika Foundation Prize (1977), the Daniel H. Efron Award (1979), the Twenty-Sixth Annual Award of the Institute of Pennsylvania Hospital in Memory of Edward A. Strecker, M.D. (1989), the William R. McAlpin, Jr. Research Achievement Award (1990), the 1993 American Psychiatric Association Award for Research in Psychiatry, the First Isaac Ray Decade of Excellence Award (1994), the Twelfth Annual Edward J. Sachar Award (1996), the 1996 Gerald Klerman Lifetime Research Award (jointly with Dr. Ellen Frank), the Institute of Medicine’s 1998 Rhoda and Bernard Sarnat International Prize in Mental Health, and the American Psychopathological Association’s 1999 Joseph Zubin Award (jointly with Dr. Ellen Frank). He was elected to the Institute of Medicine of the National Academy of Sciences in 1990.


FOUZIA LAGHRISSI-THODE, M.D.
CNS Director New Medicine Strategy F. Hoffmann-La Roche Ltd.
Basel, Switzerland

Since January 2003, Fouzia Laghrissi-Thode, M.D. has been, at F. Hoffmann-La Roche (Basel, Switzerland), a Global Head of Primary Care Business Development. She joined the Roche Group in 2000 as a CNS Leader in the New Medicines Strategy Department. Dr. Laghrissi-Thode also holds, since 1992, an appointment as an Assistant Professor in Psychiatry at Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center (USA). Prior to joining F. Hoffmann-La Roche, she worked for three years in the International Clinical Research Nervous System Department of Novartis Pharma (Basel, Switzerland). After graduating in Medicine at the University of Tours (France) in 1987 and completing residencies in General and Internal Medicine, she specialized in Psychiatry and received her European certification in 1992. As a Principal Investigator, she conducted a number of studies in depressed elderly and medically ill patients, and actively participated as co-investigator in the research conducted by the NIMH CRC for the Study of Affective Disorders and Late Life Mood Disorders.


BRENDA E. LEE
Executive Director
Mental Health Association of Allegheny County
Pittsburgh, Pennsylvania

Brenda E. Lee is the Executive Director of the Mental Health Association of Allegheny County. Prior to becoming executive director, she was the Director of Development from 1991 until May 1999.

Ms. Lee joined the Mental Health Association of Allegheny County in 1991 as Director of Development. Prior to moving to Pittsburgh, Ms. Lee was Director of Development for the American Lung Association, Planned Parenthood and the Overseas Educational Fund in Washington, D.C. Before moving to the Washington, DC area she worked for the Edna McConnell Clark Foundation, the John A. Hartford Foundation, and the Bedford-Stuyvesant Community Corporation, in New York and the Y.W.C.A. in Montclair, NJ

Ms. Lee was born in New York, raised in Montclair, NJ and is a graduate of Howard University.


LYDIA LEWIS
Executive Director
Depression and Bipolar Support Alliance
Chicago, Illinois

Lydia Lewis became President of the Depression and Bipolar Support Alliance, formerly the National Depressive and Manic-Depressive Association, in June 1997. Her primary responsibility is to position the organization as the leading resource for patients (both diagnosed and undiagnosed,) family members, professionals, legislators and the media who want (or need) to know more about mood disorders and their treatments. In addition, she is the principal spokesperson for the organization, and the primary advocate on federal level.

Ms. Lewis has spoken at the invitation of various mental health organizations, including the American College of Neuropsychopharmacology, the American Psychiatric Association, the American Psychological Association, the National Foundation for Brain Research, the National Institute of Mental Health, and the Society for Biological Psychiatry.

Manuscripts authored or co-authored by Ms. Lewis have been published in the American Journal of Psychiatry, Archives of General Psychiatry, Clinical Psychiatry News, Disease Management & Health Outcomes, Journal of Biological Psychiatry, Journal of Clinical Psychiatry, and Psychopharmacology Bulletin.

She is a member of the oversight committees of several large NIMH clinical trials and recently served on the search committee for the new director of the National Institute of Mental Health. She was a charter member of the National Institutes of Health Director’s Council of Public Representatives.

Prior to joining the DBSA, Ms. Lewis served 11 years as the Executive Director and Chief Operations Officer for The Committee of 200, the pre-eminent international association of women business executives. She also held various marketing positions at AT&T for nearly eight years.

She holds a Bachelor of Arts in psychology from the State University of New York at Buffalo. One of her proudest accomplishments has been her willingness to do life-long battle with depression, recently - after 50 years - re-diagnosed as bipolar disorder.

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