Stanley Center for the Innovative Treatment of Bipolar Disorder

FOURTH INTERNATIONAL CONFERENCE 
ON BIPOLAR DISORDER



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Biographical Sketches of Course Directors and Presenting Faculty (M - Z)

ALAN G. MALLINGER, M.D.
Professor of Psychiatry and Pharmacology
University of Pittsburgh School of Medicine
Director, Psychopharmacology of Mania and Depression Program
University of Pittsburgh Medical Center
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

During his career, Dr. Mallinger has pursued parallel interests in clinical psychiatry and basic psychopharmacology research related to mood disorders. His areas of basic research interest include laboratory studies on cell membrane phenomena and intracellular signal transduction processes, specifically, as these relate to the biological aspects of bipolar disorder and to the therapeutic mechanisms of mood stabilizing drugs. His clinical research interests include investigation of the relationship between therapeutic outcome and brain lithium level measured by magnetic resonance spectroscopy, therapeutic options for treatment-resistant mania, and mood stabilizer treatment during pregnancy. He has been involved in various clinical trials on antidepressants, mood stabilizers, and psychotherapy. Dr. Mallinger has authored or co-authored 65 scientific articles and book chapters. He is currently Director of the Psychopharmacology of Mania and Depression basic research program at WPIC, as well as Medical Director of the Maintenance Therapies in Bipolar Disorder study. He is Course Director of the Pharmacotherapy Training in Mood Disorders Clinic for psychiatry residents at the University of Pittsburgh.


PATRICK McKEON, M.D.,F.R.C.P.I., F.R.C.Psych.
Medical Director
St. Patrick’s Hospital
Professor of Clinical Psychiatry
Trinity College
Vice Chairman
Aware Defeat Depression
Dublin, Ireland

Professor McKeon in 1985 founded Aware Defeat Depression and was its chairman from 1985 to 2001. Through the Depression Research Unit at St. Patrick’s Hospital, Dublin he has conducted research into the molecular genetics of bipolar disorder, the prevalence of depression, public attitudes toward depression and the safety of l-tryptophan. He is currently Medical Director of Ireland’s largest acute care psychiatric facility and Professor at Trinity College, Dublin. His main clinical interest is in bipolar disorder and the use of psychoeducational programs for affective disorders.


ALAN METZ, M.D.
Vice President, Neuroscience
North American Medical Affairs
GlaxoSmithKline
Research Triangle Park, North Carolina

Dr. Alan Metz received his MD degree from the University of Witwatersrand in Johannesburg, South Africa followed by completion of postgraduate training at Oxford University and the New England Medical Center. Dr. Metz has spent the past 10 years in the pharmaceutical industry, holding a series of positions of increasing responsibility in the development of drugs for psychiatric indications. He currently heads the Neuroscience Division within North American Medical Affairs, GlaxoSmithKline based in Research Triangle Park, North Carolina. His academic affiliations include posts as Adjunct Associate Professor in the Department of Psychiatry at the University of North Carolina and Associate Consulting Professor of Psychiatry and Behavioral Sciences at Duke University.


DAVID J. MIKLOWITZ, Ph.D.
Professor of Psychology
Department of Psychology
University of Colorado at Boulder
Boulder, Colorado

Dr. Miklowitz did his undergraduate work at Brandeis University and his doctoral (1979-1985) and postdoctoral work (1985-88) at UCLA. He has been at the University of Colorado, Boulder since 1989. His specialty is in the family environmental factors associated with bipolar and schizophrenic disorders, and in the family treatment of bipolar disorder. He has received research investigator awards from the International Congress on Schizophrenia Research and the National Alliance for Research on Schizophrenia and Depression. He has received funding for his research from the National Institute for Mental Health and the John D. and Catherine T. MacArthur Foundation. He has published 80 research papers and book chapters on bipolar disorder and schizophrenia. His articles have appeared in the Archives of General Psychiatry, the British Journal of Psychiatry, the Journal of Nervous and Mental Disease, Biological Psychiatry, and the Journal of Abnormal Psychology. His book with Michael Goldstein, published by Guilford Press, "Bipolar Disorder: A Family-Focused Treatment Approach," won the 1998 Outstanding Research Publication Award from the American Association of Marital and Family Therapy.


PAOLO LUCIO MORSELLI, M.D.
Vice-President, Fondazione IDEA-Milano, Italy
Secretary General, GAMIAN-Europe

Professor Morselli joined the Pharmacology Department at the Medical College of Virginia, USA as a Fulbright-Hayes scholar after completing a degree in Medicine and a specialization in Psychiatry from the University of Milan, Italy in 1964. In 1967 Professor Morselli returned to Italy where he was appointed Head of the Clinical Pharmacology Unit at the “Mario Negri Institute” in Milano. In 1976 he took charge as the Director of the Clinical Research Department of the Laboratoires d’Etudes e de Recherches Synthelabo. In 1990 he was appointed Vice-President of Synthelabo Recherche Division. In 1992 he was appointed Corporate Vice-President in charge of Medical Affairs of Synthelabo Co. He served in this position till 1994. Professor Morselli has also served as Associated Scientist at the “Istitute Philippe Pinel de Montreal” Canada from 1993-1994. Since 1991, he has been a “Visiting Professor” in Clinical Neuro-psychopharmacology at the departments of Clinical Psychopharmacology and Psychiatry at “Hopital Trias y Pujol”-Badalona, Universidad Autonoma de Barcelona, Spain.

Since 1997, Dr. Morselli has served on a volunteer “pro bono” basis, as Vice President of Fondazione-I.D.E.A. (Institute for Research and the Prevention of Depression and Anxiety) in Milano, Italy. Since 1998, he has been Secretary General of GAMIAN-Europe, an European Advocacy organization operating in the field of mental disorders, and where he was one of the charter members. He is also a charter member of the International Society for Bipolar Disorders (ISBD) where he has served on the Board from 1999 to date.

Professor Morselli is a member of several scientific organizations and on the Editorial Board of 13 international scientific journals. He has authored or co-authored 476 scientific publications and served as editor or co-editor of 17 scientific specialized monographs in the field of neuropsychiatry and clinical pharmacology.

Professor Morselli’s contributions to his field have been recognized by the “Ambrogino d’oro” from the City of Milano in 1972, the ASPET/ILAE research award for “outstanding contribution in the development of anti-epileptic drugs” in 1978 and the ILAE award for “the best published clinical trial on anti-epileptic drugs” in 1983.

In 1992, he was awarded the “Prix-Galien” in Paris for the development of a new psychotropic agent. He was cited in the 1991 “Who’s Who in the World” and the 1992 “Who’s Who in Science.”


BRUNO MÜLLER-OERLINGHAUSEN, Dr.med.
Professor
Sosrschergrappa Klin.
Psychopharmakologie
Psychiatrische Klinik der Freien Universitat Berlin
Berlin, Germany

Bruno Müller-Oerlinghausen was born in 1936 in Berlin. He obtained his training in medicine at the universities of Goettingen, Munich, Frankfort/M., Freiburg, and Berlin (West). 1964 to 1969 he underwent a postgraduate training in pharmacology and toxicology at the Department of Pharmacology, University of Goettingen, and qualified as a lecturer in pharmacology and toxicology with a thesis on “Hormonal Influence on Mechanisms of Hepatic Detoxification”. 1969 to 1971 he was assigned to the Department of Medical Sciences (Ministry of Public Health) in Bangkok, Thailand, by the government of the Federal Republic of Germany as an expert in pharmacology. He built up a pharmacological research lab and trained the Thai staff in methods to investigate the pharmacology of old-style herbal medicine. In 1971 he entered the Department of Psychiatry, Freie Universität Berlin, for additional training in clinical psychiatry, and in 1974 he was appointed as Chief Scientist of the Lithium Clinic Berlin, and at the same time promoted to Professor of Clinical Psychopharmacolgy and Chief of the Laboratory of Clinical Psychopharmacology. He is editor-in-chief for “Pharmacopsychiatry”, and associate editor of many other journals, such as “Bipolar Disorders”, “Journal of Psychiatry and Neuroscience” or “Drug Research”. 1983 to 1987 he was elected as president of AGNP (Association of Neuropharmacology of the German speaking countries), 1982 to 1988 he served as Councilor of the Executive Board of CIMP. Since 1995 he is the acting chairman of the Drug Commission of the German Medical Association.

His scientific interests were mainly related to the clinical pharmacology of antidepressants, neuroleptics and particularly lithium salts in humans. Recent work focused on long-term effects of lithium salts with special regard to its sertonergic action including anti-aggressive and antisuicidal effects; serotonergic mechanisms inpatients with affective disorders; genetic studies in depression and in clozapine-induced agranulosytosis.


WILLEM A. NOLEN, M.D., Ph.D.
Professor of Psychiatry, especially Pharmacotherapy
University Medical Centre Utrecht
Altrecht Institute for Mental Health Care
Utrecht, The Netherlands

Willem A. Nolen studied medicine at the University of Leiden, and was trained in psychiatry at Psychiatric Centre Bloemendaal (nowadays Parnassia), The Hague, The Netherlands.

Besides his appointment at the University of Utrecht he is also affiliated at Altrecht Insitute for Mental Health Care in Utrecht, where he is principal investigator of the Utrecht site of the international Stanley Foundation Bipolar Network and is co-chairing a Stanley Foundation International Research Center for studies in bipolar disorder and schizophrenia.

His major research interest is mood disorders, both bipolar disorder and major depression, in which he is doing research on the epidemiology, etiology, long-term course and treatment. A main part of his research has focused on the different pharmacological treatment options in bipolar and unipolar mood disorders and their place in guidelines and algorithms. He has published 187 papers, 51 of them in international journals or as chapters in international books.

He is member of the editorial board of the Dutch Journal of Medicine (NTvG) and the Dutch Journal of Psychiatry (TvP) and is editorial consultant for several international journal. He is member of the Institutional Review Board (Medical Ethical Review Committee-METC) of the University Medical Centre Utrecht.


MICHAEL W. OTTO, Ph.D.
Associate Professor of Psychology
Harvard Medical School
Massachusetts General Hospital
Boston, Massachusetts

Michael W. Otto, Ph.D. is Director of the Cognitive-Behavior Therapy Program at Massachusetts General Hospital (MGH) and Associate Professor of Psychology at Harvard Medical School. Dr. Otto specializes in the cognitive-behavioral treatment of anxiety and mood disorders, and has developed clinical and research programs at MGH for the treatment of panic disorder, social phobia, bipolar disorder, substance dependence, and medication discontinuation in patients with panic disorder and major depression. Dr. Otto's research activities are closely tied to his clinical interests and target investigations of the etiology and treatment outcome of anxiety and affective disorders, particularly the development and testing of new treatments including the combination of pharmacologic and cognitive-behavioral strategies and interventions for treatment-refractory and substance-dependent patients. He has published over 100 articles, chapters, and books spanning these research interests. His books include Challenges in Clinical Practice: Pharmacologic and Psychosocial Strategies, co-edited with Drs. Pollack and Rosenbaum, and the Stopping Anxiety Medication treatment manuals for patients and therapists. Dr. Otto is a fellow of the American Psychological Association, directs fellowship and internship training in cognitive-behavior therapy at MGH, and has been a regular provider of continuing education and continuing medical education workshops across the United States and abroad.


ATUL C. PANDE, M.D., FRCPC
Vice President
Pfizer Global Research & Development
Ann Arbor, Michigan

Dr. Pande is a Vice President in the research and development organization of Pfizer, Inc, and is involved in managing the portfolio of compounds in clinical development for central nervous system diseases. Prior to this role, Dr. Pande established and headed the Psychiatry Clinical Research group for Parke-Davis Pharmaceutical Research (now part of Pfizer, Inc). Dr. Pande is a psychiatrist who previously held the positions of Assistant Professor of Psychiatry at the University of Michigan Medical School and then Clinical Research Physician with Lilly Research Laboratories. Dr. Pande’s research interests have covered mood and anxiety disorders, Alzheimer’s disease and neurotrauma.


ROBERT M. POST, M.D.
Chief, Biological Psychiatry Branch
Head, Stanley Foundation Bipolar Network
National Institute of Mental Health
National Institute of Health
Bethesda, Maryland

Dr. Post graduated from Yale University in 1964, the University of Pennsylvania School of Medicine in 1968, was a medical intern at the Einstein School of Medicine in 1969, and psychiatry resident at Massachusetts General Hospital for one year in 1970 before joining the NIMH. There he was clinical fellow, Section Chief, and then Chief of the Biological Psychiatry Branch for the past 18 years. His career has focused on better understanding and treating patients with refractory unipolar and bipolar illness. He helped to pioneer the introduction of the anticonvulsant carbamazepine as a major therapeutic modality in lithium-refractory bipolar patients and has studied other anticonvulsants including valproate, nimodipine, gabapentin, and lamotrigine. Exploration of some of the molecular mechanisms underlying behavioral sensitization to psychomotor stimulants and electrophysiological kindling has enabled him to reconceptualize mechanisms underlying the evolution os some neuropsychiatric illnesses at the level of change in gene expression. He is the winner of major research awards from the Society of Biological Psychiatry, APA, ACNP, Anna Monika Foundation, NARSAD, and NDMDA, and is on the editorial boards of more than ten journals. He has published more than 700 papers and has most recently helped to organize and direct the Stanley Foundation Bipolar Network in an attempt to expand the knowledge base and treatment approaches to this illness.


CATRIEN G. REICHART, M.D.
Child and Adolescent Psychiatrist
Academic Hospital Rotterdam-Sophia
Department of Child and Adolescent Psychiatry
Rotterdam, The Netherlands

Catrien G. Reichart studied medicine at the University of Utrecht. Subsequently she was trained in psychiatry in Amersfoort and Bergen op Zoom and in child and adolescent psychiatry at the Academic Medical Center in Amsterdam. She is also trained as a child and adolescent psychotherapist.

Currently she is head of the adolescent inpatient unit of the Psychiatric Department of Academic Hospital Rotterdam-Sophia, where she supervises residents and treats patients with mood disorders, first psychotic episodes and eating disorders. She is collaborator on a prospective study among 140 children of parent(s) with bipolar disorder in the Netherlands which is partly funded by the Theodore and Vada Stanley Foundation. She is also conducting a clinical trial with mood stabilizers in adolescent patients with a bipolar disorder.


A. JOHN RUSH, M.D.
Betty Jo Hay Distinguished Chair in Mental Health
Rosewood Corporation Chair in Biomedical Science
Professor and Vice-Chaiman for Research
Department of Psychiatry
University of Texas Southwestern Medical Center
Dallas, Texas

After graduating from Princeton University, Dr. Rush completed his MD at Columbia University College of Physicians & Surgeons (New York City), an internship in internal medicine at Northwestern University, Passavant Memorial Hospital (Chicago), and his residency in psychiatry at the University of Pennsylvania (Philadelphia). Dr. Rush is a Fellow of the American College of Psychiatry, the American College of Neuropsychopharmacology, and the American Psychiatric Association. He is former President of both the Society of Biological Psychiatry and the Society for Psychotherapy Research. He chaired the DSM-IV Work Group on Mood Disorders and the Panel on Practice Guidelines for Depression in Primary Care for the Agency for Health Care Policy and Research. Dr. Rush has also served on review committees of the National Insitute of Mental Health and the Department of Veterans Affairs. He is an editorial board member or reviewer for over a dozen psychiatric journals.

Honors include Exemplary Psychiatrist of the Year by the Texas Society of Psychiatric Physicians, the Gerald L. Klerman Lifetime Research Award (National Depressive and Manic Depressive Association), the Strecker Award (Institute of Pennsylvania Hospital), the Charles C. Burlingame Award (Institute for Living), the Mood Disorder Research Award (American College of Psychiatrists), the Edward J. Sachar Award (Columbia College of Physicians and Surgeons) and the Award in Mood Disorders Research from NARSAD for his research, teaching, and clinical work. For over 30 years, he has conducted clinical investigations of both biological and psychosocial issues in mood disorders in adults, children, and adolescents. He has promoted the application of clinical research findings to practice to improve the diagnosis and treatment of these patients. Dr. Rush has published over 245 papers, 73 chapters, and 10 books.


GARY S. SACHS, M.D.
Assistant Professor of Psychiatry
Harvard Medical School
Director, Bipolar Clinic and Research Program
Boston, Massachusetts

Gary S. Sachs, M.D., is Director of the Bipolar Treatment Center, Director of the Bipolar Mood Disorder Program in the Clinical Psychopharmacology Unit, Director of the Harvard Bipolar Research Program, and an Assistant Professor of Psychiatry at Massachusetts General Hospital (MGH), in Boston, Massachusetts.

A 1982 graduate of the University of Maryland School of Medicine, Dr. Sachs has held such distinguished positions as Chief Resident, Acute Psychiatry Service, Clinical Fellow in Psychiatry, and Director of the Chronobiology Section in the Clinical Pyschopharmacology Unit as MGH. Among his many achievements and accolades, Dr. Sachs has received the Dupont-Warren Fellow from the Harvard Medical School, as well as the Dunlop Award for his achievements in psychiatric research and writing.

A pioneer in the understanding and treatment of bipolar disorder, Dr. Sachs sits on the review boards of such nationally recognized publications as The American Journal of Psychiatry, the New England Journal of Medicine and the Journal of Clinical Psychiatry. In addition, Dr. Sachs is currently a member of such notable medical associations as the American Psychiatric Association, and the American Medial Association.

Dr. Sachs is principal investigator for the National Institute of Mental Health (NIMH) sponsored study entitled, the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP B-D). STEP B-D is the first-ever, long-term study that emphasized the continuity of care for all people with bipolar disorder.


AMY SCHLONSKI, L.S.W.
Therapist
Bipolar Services Clinic
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Amy Schlonski, L.S.W. has a Bachelors of Science Degree in Human Development and Family Studies from the Pennsylvania State University and a Masters of Social Work from the New Mexico State University. For the past 12 years, she has been practicing individual and family psychotherapy with diverse populations. Since 1998, Ms. Schlonski has been at the Child and Adolescent Bipolar Disorder Services (CABS) Clinic, using cognitive behaviors therapy and family focused therapy as an adjunct treatment of Bipolar Disorder.


MOGENS SCHOU, M.D., DR. MED. SCI.
Honorary President
International Society for Bipolar Disorders
Emeritus Professor
The Psychiatric Hospital
Denmark

Mogens Schou was born in Copenhagen 1918. After graduation from Copenhagen University Medical School in 1944 he trained in clinical psychiatry at Danish, Norwegian and Swedish hospitals and in experimental biology at institutes in Copenhagen, New York, and Aarhus.

From 1951 Dr. Schou worked at the psychiatric hospital, Risskov, Denmark, from 1956 as head of its Psychopharmacology Research Unit. In 1971 he was appointed to a newly created chair of biological psychiatry at Aarhus University. He retired in 1988.
In 1952 Dr. Schou and his associates gave lithium to their first manic patient, and in 1954 they published the outcome of a partly open, partly randomized and placebo-controlled trial, the first of its kind in psychiatric pharmacotherapy. It fully confirmed the antimanic effect of lithium, first observed in 1949 by John Cade. In the 1960’s the Danish psychiatrist Paul Christian Baastrup and Mogens Schou carried out a study of lithium treatment in patients with recurrent manic-depressive disorder. It ran over six and a half years, involved 88 patients, and was published in 1967. It showed that long-term lithium treatment was associated with a marked (87 per cent) and long-lasting fall in the frequency of manic and depressive recurrences, that the effect was the same in bipolar and unipolar patients, and that the efficacy of lithium did not disappear with time or after interruption and subsequent resumption of the treatment.

This was the first long-term treatment, which could break the almost inexorable development of manic and depressive recurrences. Prophylactic or recurrence-preventive lithium treatment was taken into use by other psychiatrists, who confirmed its efficacy. The Danish trial was, however, criticized on methodological ground by psychiatrists who had never themselves given lithium. Baastrup, Schou, and their associates now carried out two randomized, placebo-controlled, parallel-group, prospective discontinuation trials. They were terminated after six months by a sequential analysis and showed a highly significant difference between lithium and placebo in both bipolar and unipolar patients. After publication of this study in 1970, lithium became fist-choice mood stabilizer in bipolar disorder, whereas its considerable ability to prevent recurrent depressions has been disregarded. Antidepressant drugs have dominated this field, even if an extensive comparative study has shown lithium significantly more efficacious than amitriptyline.

Over the years Dr. Schou has published more than 530 articles, books and book chapters. His studies have dealt with the effect of lithium treatment on artistic creativity, treatment management and monitoring, treatment regimen, somatic and psychological side effects, the effects of lithium treatment on kidney and thyroid function, interaction with other drugs, acute and late effects of intoxication. Together with an international research team, IGSLI, which he initiated, Dr. Schou has studied the effect of long-term lithium treatment on mortality and suicidal behavior as well as the genetics of ‘excellent lithium responders’. Since lithium cannot be patented, it has received limited commercial support, and Dr. Schou has therefore lectured extensively to psychiatrists, hospital physicians, general practitioners, and patient groups. He has written books (that have appeared in twelve languages) in non-technical language for patients and relatives.

Dr. Schou has received a number of honors and awards, including the Danish Alfred Benzon and Ernst Carlsen Prizes 1967 and 1968, first Prize from the German Anna-Monika Stiftung 1969 (for work carried out with J.Angst, P.C.Baastrup, P.Grof and P.Weis), the German Paul Martini Prize 1969 (with the same), the Danish Novo Foundation Prize 1971, the International Scientific Kittay Foundation Award 1974 (shared with John Cade), the Taylor Manor Hospital Psychiatric Award 1978, the Great Nordic Fernström Prize 1979, the John Cade Memorial Award 1982, the National Depressive and Manic-Depressive Association's Abraham Lincoln Award 1987, the Mary and Albert Lasker Clinical Medical Research Award 1987, the American David R. Wood Award 1988, the Lundbeck Foundation's Research Prize 1988, the International Society of Lithium Research’s Mogens Schou Prize for Lifetime Achievement 1995, and the CINP Pioneers in Psychopharmacology Award 2000.

Dr. Schou is honorary Fellow of the Royal College of Psychiatrists (Great Britain), Collegium Internationale Neuro-Psychopharmacologium, the British Association of Psychopharmacology, the Scandinavian Society for Psychopharmacology, and many other scientific societies. He holds honorary doctorates from universities in Marseille, Munich, and Prague.

Dr. Schou and his wife have four daughters, three sons-in-law, and seven grandchildren.


GREGORY SIMON, M.D., M.P.H.
Investigator
Center for Health Studies
Group Health Cooperative
Research Associate Professor
Psychiatry and Behavioral Sciences
University of Washington
Seattle, Washington

Dr. Simon is a senior investigator at the Center for Health Studies of Group Health Cooperative and holds a faculty appointment at the University of Washington. His previous research has examined a range of topics related to affective disorders including epidemiology, societal burden, quality of care, and cost-effectiveness of alternative treatment programs. His current research focuses on the effectiveness and cost-effectiveness of systematic care programs for unipolar depression and bipolar disorder. Dr. Simon serves on the Scientific Advisory Board of the National Depressive and Manic-Depressive Association and on the editorial board of Psychological Medicine, Effective Clinical Practice, General Hospital Psychiatry, and the Western Journal of Medicine. Dr. Simon continues to practice adult psychiatry (approximately 40% time) at Group Health Cooperative.


JAIR C. SOARES, M.D.
Assistant Professor of Psychiatry
University of Pittsburgh School of Medicine
Director, Neurochemical Brain Imaging Laboratory
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Dr. Jair C. Soares graduated in 1990 from the University of Sao Paulo School of Medicine, Brazil. After psychiatric residencies at the University of Sao Paulo (1991-1993), and at the Western Psychiatric Institute and Clinic, University of Pittsburgh (1993-1997), he took a brain imaging fellowship at the department of Psychiatry at Yale University (1997-1999). He has held an appointment as an Assistant Professor of Clinical Psychiatry at the University of Pittsburgh School of Medicine since 1997, and in 1999 joined its faculty on a full-time basis as an Assistant Professor of Psychiatry. Dr. Soares had had extensive clinical research experience in the field of mood disorders, and expertise with neuroimaging modalities as research tools to investigate these disorders. Dr. Soares has published several peer-reviewed articles and book chapters in the psychiatric literature. Since 1998, he has been co-editing a new peer-review journal called “Bipolar Disorders – An International Journal of Psychiatry and Neurosciences”. He recently co-edited a textbook on "Bipolar Disorders - Basic Mechanisms and Therapeutic Implications". He currently directs the Neurochemical Brain Imaging Laboratory at Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, where he is conducting brain imaging studies that attempt to elucidate causation of bipolar and unipolar mood disorders, and the mechanisms of action of treatments for these conditions.


JITSCHAK STOROSUM, M.D.
Psychiatrist
Academic Medical Center, Amsterdam
Clinical Assessor
Medicines Evaluation Board of the Netherlands

Dr. Storosum has published articles on AIDS and psychiatry and on methodological and clinical issues in psychopharmacology studies. Moreover he wrote three thrillers (the Medicine Makers awarded the Havink Award for best debut). Dr. Storosum is supervisor at the psychiatric inpatient department of the Academic Medical Center and treats mainly schizophrenic patients and patients with mood disorders.


MICHAEL E. THASE, M.D.
Professor of Psychiatry
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Michael E. Thase, M.D., is a Professor of Psychiatry at the University of Pittsburgh School of Medicine and the Western Psychiatric Institute and Clinic. He is an active clinical investigator, whose research focuses on the assessment and treatment of mood disorders, including the correlates of differential response to various treatments for depression. A 1979 graduate of the Ohio State University College of Medicine, Dr. Thase has directed the Depression Treatment and Research Program at the University of Pittsburgh since its inception in 1987 and is now the Chief of Adult Academic Psychiatry. A Fellow of the American Psychiatric Association, Dr. Thase has authored or co-authored over 325 scientific articles, book chapters, and books.


LEONARDO TONDO, M.D.
Department of Psychiatry, Harvard University and McLean Hospital
Belmont, Massachusetts
Assistant Professor in Psychiatry
Dipartimento di Psicologia, Università degli Studi di Cagliari
Director, Centro Lucio Bini, Stanley Foundation Research Center
Cagliari, Sardinia

Dr. Tondo is the director of Centro Bini in Cagliari, Sardinia, since its foundation in 1977. This outpatient clinic specializing in the treatment of mood disorders has been designated as a Research Center by the Theodore and Vada Stanley Foundation since 1998. Dr. Tondo completed his medical education at the University of Rome in 1974 and in 1980 received a permanent appointment as assistant professor at the University of Cagliari. He was a visiting scientist at the Psychohormonal Unit at Johns Hopkins University in 1980, lecturer in psychopharmacology at the University of Pennsylvania in 1983, and a researcher in psychobiology at the University of California at Los Angeles in 1986. Since 1995 he has been a research associate in the Department of Psychiatry at Harvard University and the McLean Division of Massachusetts General Hospital with Professor Ross J. Baldessarini, with whom he organized the International Consortium for Bipolar Disorder Research. His research is concentrated on the course and treatment of bipolar disorders. He oversees clinical care at one of the largest private psychiatric outpatient clinics in Italy and treats mood disorder patients himself. In collaboration with Professor Baldessarini and other international colleagues, he has contributed to quantifying the effects of discontinuing maintenance treatment in bipolar disorders and on the protective effects of lithium treatment on suicidal behavior in such patients. He has been the recipient of NARSAD Young Investigator and Independent Investigator Awards, and grants from the Stanley Foundation and the American Foundation for Suicide Prevention. Dr. Tondo is the author of more than one hundred publications, is chief editor of the Italian Journal of Addictions, and reviewer for the Archives of General Psychiatry, Journal of Clinical Psychiatry, and Bipolar Disorder. He is vice president of the Aretaeus Association, an international organization that encourages research on mood and anxiety disorders. He is also a consultant to the Italian National Press and contributes to newspapers and radio programs on mental health matters.


PER VESTERGAARD, Dr.Med.Sc.
Professor of Psychiatry
Aarhus University
Chairman of Clinical Psychiatry, Department A
Aarhus University Psychiatric Hospital
Risskov, Denmark

Dr. Vestergaard is Professor of clinical psychiatry of Aarhus University, Denmark, and chief of clinical services at the University Psychiatric Hospital. He founded the Mood Disorders Research Unit and the Lithium Clinic of the Aarhus Psychiatric Hospital. He has conducted research and published articles on the clinical pharmacology of lithium, on the treatment efficacy of old and new antidepressant drugs, on affective disorders in general and bipolar disorder in particular. He was a co-founder of the Danish University Antidepressant Group (DUAG). He has published under-graduate textbooks on psychiatry and is an editorial consultant on several psychiatric journals including Acta Psychiatrica Scandinavica and Pharmacopsychiatry. Dr. Vestergaard is a board member of the Scandinavian College of Neuro-psychopharmacology (SCNP) and a recipient of Stanley Foundation grants.


ADELE C. VIGUERA, M.D.
Associate Director
Perinatal and Reproductive Psychiatry
Clinical Research Program
Massachusetts General Hospital
Instructor in Psychiatry
Harvard Medical School
Boston, Massachusetts

Adele C. Viguera, M.D., is the Associate Director of the Perinatal and Reproductive Psychiatry Program at Massachusetts General Hospital and an instructor in psychiatry at Harvard Medical School in Boston, Massachusetts. Dr. Viguera received her M.D. from Dartmouth Medical School in Hanover, New Hampshire, and served her internship and residency at Massachusetts General Hospital and McLean Hospital in Belmont, Massachusetts.

The recipient of several honors and awards, Dr. Viguera is a recent recipient of an NIMH sponsored K23 Mentored Patient-Oriented Research Career Development Award as well as a NARSAD Young Investigators Award for her project on neonatal outcome following exposure to Lithium: What Happens to Lithium Babies? Her current research interests include the course and treatment of bipolar mood disorders during pregnancy and the postpartum period and the effects of prenatal lithium exposure on infant development. Her work has been published in a number of scientific journals and books.


SUSAN WASSICK, R.N.
Coordinator
Child and Adolescent Bipolar Services Clinic
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Susan Wassick is a Registered Nurse sho has been working in Child and Adolescent Psychiatry for 20 years. She has extensive experience in evaluation and treatment of children and adolescents with mood disorders. She has been the nurse clinician at the Child and Adolescent Bipolar Services Clinic since it opened in 1998.


ROBERT M. WETTSTEIN, M.D.
Clinical Professor of Psychiatry
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Dr. Wettstein is in the private practice of psychiatry, with an emphasis on legal and ethical practice issues. He is a consultant to the state licensing boards in medicine, psychology, nursing, dentistry, chiropractic, and law, and evaluates impaired professionals. He also conducts independent examinations regarding disability, workers compensation, and criminal responsibility.

Between 1984 and 1996, Dr. Wettstein was on the full-time faculty at WPIC, and was codirector of the Law and Psychiatry Program. He was involved in clinical consultations, treatment, and research activities in the law and psychiatry area. In 1996, he was awarded the “Golden Apple” award for excellence in teaching by the residents of WPIC.

Dr. Wettstein was Editor of the quarterly journal Behavioral Sciences and the Law until 1996. He is coauthor with Barbara Weiner, Esq. of Legal Issues in Mental Health Care. His edited volume, Treatment of Offenders with Mental Disorders, was published in 1998. He is also author of many other publications on legal and ethical issues in mental health care.

He served as Vice President of the American Academy of Psychiatry and the Law from 1999-2000.

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