Stanley Center for the Innovative Treatment of Bipolar Disorder

FOURTH INTERNATIONAL CONFERENCE 
ON BIPOLAR DISORDER



Introduction

Proceedings

Bipolar Conferences Home

Biographical Sketches of Course Directors and Presenting Faculty (A - L)

JULES ANGST, M.D.
Epidemologic Research
Zurich University Psychiatric Hospital
Zurich, Switzerland

Jules Angst is Emeritus Professor of Zurich University, Honorary Doctor of Heidelberg University and Past-President of the Association of European Psychiatrists.

A graduate of Zurich University Medical School in 1952; he was appointed lecturer in Clinical Psychiatry in 1966; Assistant Professor in 1967; Professor of Clinical Psychiatry in 1969 and Head of the Research Department of Psychiatric University Hospital 1969-1994.

Jules Angst has received many awards in recognition of his work: Anna Monika Awards (1967/1969), Otto Naegeli Prize (1983), Emil Kraepelin Medal in gold, Max Planck Institute, Munich (1992); Selo Prize NARSAD / Depression Research, USA (1994).

He is an Honorary Fellow of Royal College of Psychiatrists, Mexican, Chilean, Polish and Austrian Psychiatric Associations, Swiss Society of Psychiatric Epidemiology, German Association of Biological Psychiatrists, American Psychopathological Association, European College of Neuropsychopharmacology, Swiss Society of Biological Psychiatry, European College for Study Methods in Clinical Trials, Association of European Psychiatrists.


DAVID AXELSON, M.D.
Assistant Professor of Psychiatry
University of Pittsburgh School of Medicine
Director, Child and Adolescent Bipolar Service
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

David Axelson, M.D., is the Medical Director, Child and Adolescent Bipolar Services (CABS), Western Psychiatric Institute and Clinic (WPIC). Dr. Axelson earned his medical degree at Duke University and completed his general and child psychiatric training at University of Pittsburgh – WPIC. He completed a post-doctoral research fellowship in child and adolescent mood disorders at University of Pittsburgh – WPIC and has been on faculty as an Assistant Professor since April 2000. He has been medical director of CABS for the past year and his research focus is the assessment and treatment of pediatric bipolar disorder.


MARK S. BAUER, M.D.
Acting Chief of Staff and Chief
Mental Health and Behavioral Sciences Service
Providence VA Medical Center
Associate Professor of Psychiatry
Brown University School of Medicine
Providence, Rhode Island

Dr. Bauer received his B.A. from the University of Chicago and his M.D. from the University of Pennsylvania. He is currently Associate Professor of Psychiatry at Brown University and on staff at the Providence (RI) Veterans Affairs Medical Center.

Dr. Bauer has served as Principal Investigator on federal grants each year since his fellowship and has received awards for research, administration, and clinical care including twice being named Exemplary Psychiatrist by the National Alliance for the Mentally Ill.

Dr. Bauer’s main scientific contributions include: (a) use of high dose thyroid hormone treatment for rapid cycling bipolar disorder; (b) assessment, phenomenology, and course in bipolar disorder; and (c) controlled trials of methods to improve treatment delivery in bipolar disorder.


BORIS BIRMAHER, M.D.
Associate Professor of Psychiatry
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Dr. Birmaher is the co-director of the Children and Adolescent Bipolar Clinic, University of Pittsburgh Medical Center. He has conducted research in the clinical presentation, longitudinal outcome, biology, and pharmacological and psychosocial treatments of children and adolescents with major depressive, bipolar, and anxiety disorders. In addition, he has developed psychiatric interviews and ratings scales for the assessment of children with mood and anxiety disorders. Dr. Birmaher has received support from the National Institute of Mental Health to fund his research for adolescents with bipolar disorders and also children of bipolar parents. He has published many articles and book chapters related to mood and anxiety disorders in children and adolescents. Dr. Birmaher is a member of the editorial board of the Journal of the American Academy of Child and Adolescent Psychiatry and he serves as editorial consultant to several journals including the American Journal of Psychiatry, Archives of General Psychiatry, and Biological Psychiatry. In addition to his research, Dr. Birmaher teaches and supervises residents, medical students and fellows from other countries, and provides treatment to an extensive patient population. He has twice been the recipient of the Golden Apple Award for teaching at WPIC, received an award for clinical excellence while a resident in child psychiatry, and numerous awards for research. Recently he was named “Health Care Hero” by the Pittsburgh Business Times for his work with bipolar children and their parents.


GIOVANNI BATTISTA CASSANO, M.D.
Professor of Psychiatry
University of Pisa School of Medicine
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology
University of Pisa
Pisa, Italy

Giovanni Battista Cassano is Full Professor of the School of Medicine, University of Pisa, Italy since 1978. He is also a fellow of The Royal College of Psychiatrists, member of the American Psychopathological Association and of the Geselleschaft Osterreichischer Nervenarzte und Psychiater. He was founder of The International Committee for Prevention and Treatment of Depression and foreign corresponding member of the American College of Neuropsychopharmacology (ACNP) since 1995, and member of the European College of Neuropsychopharmacology (ECNP) since 1987.

His scientific background moves from basic to clinical psychopharmacology, with special regard to the methodological aspects of clinical trials with psychoactive drugs. Thanks to his contribution in this area, Professor Cassano obtained a 6-year grant (from 1980-1986) from the “National Institute of Mental Health”.

Professor Cassano conducted and coordinated a large number of clinical studies, to test the efficacy and safety of antidepressants, anxiolitics, antipsychotics, and mood stabilizers. He is dedicated to research in different psychopathological and clinical areas, with special interest in the diagnosis, classification, and short-term/long-term treatment of mental disorders.

In the last 5 years, Professor Cassano has lead an international group of clinical researchers (‘Spectrum Project’, involving the University of Pisa, the Western Psychiatric Institute of Pittsburgh, the Columbia University of New York, and the University of California-San Diego), for the assessment of sub-clinical, soft, and atypical manifestations of bipolar, anxiety, and eating disorders. Along this collaboration, structured interviews for the evaluation and the assessment of sub-threshold manifestations of mood (SCI-MOODS™), panic (SCI-PAS™), eating (SCI-ABS™), obsessive-compulsive (SCI-OBS™), social-phobic (SCI-SHY™), post-traumatic stress disorders (SCI-PTSD™), and substance abuse (SCI-SUB™) have been developed.

Professor Cassano is author of over 500 scientific publications on nosology, diagnosis and treatment of psychiatric disorders. Moreover, he is co-author of a best-selling book for the Italian public.

Professor Cassano is currently Chief of the Department of Psychiatry, University of Pisa, where he is leading a group of researchers and clinicians, who have combined expertise both in academic and clinical psychiatry, advancing the understanding of the ‘spectrum’ concept in mood, anxiety and eating disorders.


PAULA J. CLAYTON, M.D.
Clinical Professor of Psychiatry
University of New Mexico School of Medicine
Albuquerque, New Mexico
Professor Emeritus
Department of Psychiatry
University of Minnesota Medical School
Minneapolis, Minnesota

Dr. Paula Clayton attended the University of Michigan where she received a Bachelor of Science degree in 1956. She graduated AOA from Washington University School of Medicine in St. Louis, Missouri in 1960. After an internship, she took her psychiatry residency at Washington University. She became an instructor and chief resident in 1965/66. Thereafter, she joined the faculty and progressed from an assistant professor to associate to full professor in 1976. In July of 1981 she moved to Minnesota to become Professor and Head of the Department of Psychiatry. In 1969 she published, with Drs. Winokur and Reich, the first textbook on mania, entitled Manic Depressive Illness. She has published three additional books, 150 papers in refereed journals, and 20 book chapters. Her areas of expertise and research are mood disorders, particularly bipolar and unipolar disorders, and bereavement. She continues to write in these areas.

She is a Fellow in the American Psychiatric Association and a member of the American Psychopathological Association, the American College of Neuropsychopharmacology, and the Society of Biological Psychiatry. She was on the DSM-III Task Force for Nomenclature and Statistics. She has been the President of the American Psychopathological Association, Psychiatric Research Society, and Society of Biological Psychiatry. She is on editorial boards, has been a panel member for AAMC, for the Institute of Medicine, and for the VA Medical Centers. She was a member of the National Board of Medical Examiners Psychiatry Test Committee and a member of the FDA. In 1985, she received the Athena Award from the University of Michigan for being the outstanding woman alumna of the year. She also received a Distinguished Alumnae Award in 1985 from Washington University and in 1993 the First Aphrodite Jannopaulo Hofsommer Award from Washington University.


RODNEY ELGIE
President, GAMIAN-Europe
Kent, United Kingdom

Rodney Elgie is aged 56 and trained as a solicitor in the later half of 1960’s, and remained in private practice for over 20 years, rising to the position of senior partner of the firm for his last six years.

Having suffered from clinical depression in the late 1980’s/early 1990’s, he joined Depression Alliance on a voluntary basis in 1994 and became its first paid staff member a year later. Elgie was responsible for overseeing the substantial growth of the charity over the next five years so that it is now clearly established as the UK’s leading organization within the field of depression with four major regional offices.

In the autumn of 1999, Elgie took on the role of European Development Director for GAMIAN-Europe (Global Alliance of Mental Illness Advocacy Networks), which is Europe’s principal patient driven federation and today has 43 national association members from 22 European countries and associate members from the other continents. The registered charity covers all aspects of mental illness including schizophrenia, bipolar disorder, clinical depression, obsessive compulsive disorders, phobia and anxiety. In October, 2000, Elgie was elected President of GAMIAN-Europe and now works to raise the profile and importance of mental health among members of the European Parliament and the European Commission. He maintains collaborative working with the Hungarian, Lithuanian and Ukrainian Nursing Associations within the field of mental health, is currently working with the Central Association of Psychiatry in Moscow to develop a training package for potential self-help group leaders for people with a mental illness. On behalf of the European Commission, Elgie is undertaking a major literature review on suicide and parasuicide across Europe and will shortly commence work on investigating the health, social, financial, cultural, and welfare problems experienced by women over the age of 65 on a pan European basis.

Elgie was from 1997 until the 17th January, 2001, the UK’s Board representative of the International Alliance of Patient Organizations. He is currently a member of the Scientific Committee of the Mental Health Foundation in London and the Royal College of Psychiatrist’s Patients and Carers Liaison Committee, a board member of the Health Coalition Initiative in the UK and an expert panel member on various national and international bodies, including pharmaceutical companies.

He has written numerous articles on mental health and men’s health from the patient’s perspective, is a frequent contributor to BBC’s radio programs on mental health and speaks at numerous health conferences and congresses both in the UK and internationally.


ELLEN FRANK, Ph.D.
Professor of Psychiatry and Psychology
University of Pittsburgh School of Medicine
Director, Depression and Manic Depression Prevention Program
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Dr. Ellen Frank is Professor of Psychiatry and Psychology at the University of Pittsburgh School of Medicine and Director of the Depression and Manic Depression Prevention Program at Western Psychiatric Institute and Clinic. She graduated from Vassar College in 1966 and received a masters’ degree in English from Carnegie Mellon University in 1967. Her doctoral work in psychology was done at the University of Pittsburgh and completed in 1979.

Under a MERIT Award grant from the National Institute of Mental Health, Dr. Frank is currently studying the efficacy of Interpersonal and Social Rhythm Therapy, a psychotherapy she and her colleagues developed for the treatment of manic-depressive illness. It is intended as an adjunct to appropriate pharmacotherapy. She is also conducting an NIMH-sponsored study of women with recurrent depression in which she hopes to sort out how biology, life stress, and different “doses” of psychotherapy interact in increasing or decreasing vulnerability to new episodes of depression. In addition, Dr. Frank is currently involved in a project based at the University of Pisa, Italy aimed at achieving a better understanding of the clinical importance of subsyndromal mood, anxiety and eating disorders.

An expert in mood disorders and their treatment, Dr. Frank was a member of the American Psychiatric Association Task Force on DSM-IV and was Chair of the Food and Drug Administration Psychopharmacologic Drugs Advisory Panel. Dr. Frank is currently a member of the National Advisory Mental Health Council and the National Institute of Health Panel on Scientific Boundaries for Review. Dr. Frank also serves as Chair of the American College of Neuropsychopharmacology’s Ethics Committee. She is an Honorary Fellow of the American Psychiatric Association. In 1999, Dr. Frank was elected to the National Academy of Sciences Institute of Medicine.


BARBARA GELLER, M.D.
Professor of Psychiatry
Washington University School of Medicine in St. Louis
St. Louis, Missouri

Dr. Geller is a Professor of Psychiatry at Washington University School of Medicine in St. Louis where she is principal investigator on NIMH funded grants to study the diagnosis, longitudinal course, psychosocial functioning and family psychopathology of prepubertal children and early adolescents who have bipolar disorders. She has published over 95 articles on childhood mania and on the psychopharmacology and longitudinal course of prepubertal major depressive disorders. Dr. Geller has served on and chaired numerous federal advisory committees at the NIMH, NIDA and FDA and is on multiple editorial boards. Dr. Geller is the recipient of the American Academy of Child and Adolescent Psychiatry Nathan Cummings Special Research Award, the NAMI Exemplary Scientist Award and the St. Louis AMI Outstanding Scientist Award. She has served on the Board of Directors of the St. Louis DMDA and is currently on the Board of Directors of the Child and Adolescent Bipolar Foundation.


VALENTIM GENTIL, M.D., Ph.D.
Professor of Psychiatry, University of São Paulo Medical School
Chairman, Institute of Psychiatry, Hospital das Clínicas
São Paulo, Brazil

Dr. Gentil completed his medical studies and residency in Psychiatry at the Department and Institute of Psychiatry in São Paulo, and then was a post-graduate student at the Institute of Psychiatry and Maudsley Hospital in London, UK, where he obtained his PhD in Clinical Psychopharmacology under the supervision of Professor Malcolm Lader. Back to Brazil, Dr.Gentil was assistant and then associate professor in the Departments of Pharmacology (until 1987) and Psychiatry (1986-current) of the University of São Paulo. His teaching, clinical and reseach activities include work in the areas of diagnosis, treatment and psychophysiology of mood and affective disorders. He was Head of the Department of Psychiatry in 1992-96, and since 1994 he is Professor and Chairman fo the Institute of Psychiatry, a 200 bed academic psychiatric complex within the 2000 bed medical centre of the USP Medical School. His current interests include a collaborative investigation of the psychobiological mechanisms of emotional response regulation and appetite/weight control under antidepressants, and the development of an efficient program for bipolar disorder prevention. He has published 62 articles in peer-reviewed journals and is a member of the editorial boards of Bipolar Disorder, Molecular Psychiatry, Journal of Psychopharmacology, and Stress Medicine, among other scientific journals. Besides his academic and clinical activities, Dr.Gentil serves in the advisory board of ABRATA - Brazilian Association of Affective Disorders, a non-professional organization.


EARL L. GILLER, Jr., M.D., Ph.D.
Senior Director, CNS Clinical Development
Pfizer Global Research and Development
Groton, Connecticut
Adjunct Associate Professor of Psychiatry
Yale School of Medicine
New Haven, Connecticut

Dr. Giller is a senior leader in the CNS therapeutic area at Pfizer, Inc., responsible for phase II and III clinical trials in the development of new psychotropic medications. He contributed to the development of sertraline (Zoloft) for post-traumatic stress disorder and to ziprasidone (Geodon) for schizophrenia. He is currently leading the clinical team in the development of a new antidepressant. Before coming to industry, Dr. Giller conducted research in monoamine oxidase activity, post-traumatic stress disorder, neuroendocrinology and the pharmacologic treatment of schizophrenia, mood and anxiety disorders, with publications in all of these areas. He has been funded by the VA through Career Development and Merit Review awards, and by NIMH. He has served as a grant reviewer for the VA and NIMH. In addition to research, Dr. Giller has run both inpatient and outpatient programs.


GIOVANNI De GIROLAMO, M.D.
Coordinator
National Institute of Health
National Mental Health Project
Rome, Italy

Giovanni de Girolamo was born in Naples (Italy) on April 3, 1953. He graduated in 1977 from the 2nd Medical School, University of Naples. In 1981 he completed his residency in Psychiatry at the Institute of Psychiatry of the 2nd Medical School, University of Naples. He worked at the Departments of Mental Health in Cremona and Turin (Italy) from 1978 to 1988. In the years 1988-1994 he was appointed initially as Associate Professional Officer and subsequently as Medical Officer at the Division of Mental Health of the World Health Organization in Geneva (CH). From 1994 to 1998 he was Consultant Psychiatrist at the 2nd University Psychiatric Clinic and at the Department of Mental Health in Bologna (I). From 1998 up to now he has been the Coordinator of the ‘National Mental Health Project’ at the Italian National Institute of Health in Rome. He has received fellowships to spend some time as visiting scientist at the Institute of Psychiatry (London, U.K.), the Institute of Psychiatric Demography (Aarhus, Denmark) and the Western Psychiatric Institute and Clinic, Pittsburgh (USA). He has promoted several research activities internationally and in Italy, and has organized many workshops, seminars and training courses with international speakers in Italy. He is the author, editor or translator (into Italian) of 30 books or monographs, of more than 98 papers and 35 book chapters. He has also lectured extensively.


FREDERICK K. GOODWIN, M.D.
Director
Center on Neuroscience, Medical Progress and Society
Research Professor of Psychiatry
Department of Psychiatry
Director, Psychopharmacology Research Center
George Washington University Medical Center
Washington, DC

Frederick K. Goodwin, M.D., is Research Professor of Pscyhiatry at the George Washington University and Director of the University’s Psychopharmacology Research Center where he conducts research on manic-depressive illness. He also directs the Center on Neuroscience, Medical Progress, and Society at the George Washinton University Medical Center. At the Center, Dr. Goodwin’s policy studies focus on the impact of changing patterns of health care on quality and innovation in medicine.

Dr. Goodwin is the former Director of the National Institute of Mental Health (NIMH), the largest research and research training institution in the world dedicated to the application of biological, behavioral, and social science to the treatment and prevention of mental illness and refinement of mental health services. Prior to that, he held a Presidential appointment as head of the Alcohol, Drug Abuse, and Mental Health Administration. A physician-scientist specializing in psychiatry and psychopharmacology, Dr. Goodwin served from 1981 to 1988 as NIMH Scientific Director and Chief of Intramural Research. He joined the NIMH in 1965 and has become an internationally recognized authority in the research and treatment of major depression and manic-depressive illness. For example, he was first to report the antidepressant effects of lithium in a controlled study.

A graduate of Georgetown University, Dr. Goodwin received his M.D. from St. Louis University, and took his psychiatric residency at the University of North Carolina in Chapel Hill. He is a Member of the institute of Medicine of the National Academy of Sciences and a Fellow of the ACNP. He serves on the editorial boards of key scientific journals, including the Archives of General Psychiatry, The Journal of Clinical Psychopharmacology and is a founder of Psychiatry Research.

Dr. Goodwin is a recipient of the major research awards in his field including the Hofheimer Prize from the American Psychiatric Association, the International Anna-Monika Prize for Research in Depression, the Edward A. Strecker Award, the Lieber Prize from NARSAD, the McAlpin Award, the Distinguished Service Award from NAMI, and the Research Award from the American Foundation for Suicide Prevention.

He was the first recipient of the Psychiatrist of the Year from Psychiatric Times, and the Fawcett Humanitatian Award of the NDMDA. In 1998 he was elected President of the Psychiatric Research Society.

The author of 420 publications, Dr. Goodwin (with K.R. Jamison, Ph.D.) wrote Manic-Depressive Illness, the first psychiatric text to win the Best Medical Book award from the Association of American Publishers. He is one of five psychiatrists on the Current Contents list of the most frequently cited scientists in the world and one of twelve psychiatrists listed in The Best Doctors in the U.S.

In addition to his work at the George Washington University Medical Center and his private practice, Dr. Goodwin is the host of the award winning The Infinite Mind radio show. This one hour national weekly public radio program is dedicated to issues relating to the mind, the brain, and mental illness. The program is now carried in more than 150 markets. It’s estimated 500,000+ listeners make it the most popular health show in public radio.


GUY M. GOODWIN, M.D.
W.A.Handley Professor of Psychiatry
University Department of Psychiatry
Warneford Hospital
Oxford, England

Professor Goodwin is W. A. Handley Professor of Psychiatry and Head of the University department of Psychiatry at the University of Oxford. His research interests are in the treatment of severe psychiatric illness and the application of neuroscience in understanding the neurobiology of mood disorder. Currently, he is involved in projects on the neurobiology and genetics of vulnerability to mood disorder and the neuropsychology of manic mood disturbance. He is also developing the basis for a large scale pragmatic clinical trial in bipolar affective disorder. He has served on the Wellcome Trust Neurosciences Panel, is president-elect of the British Association for Psychopharmacology and a non-executive member of the Board of the Oxfordshire Mental Healthcare NHS Trust.


IAN M. GOODYER, M.D. F.Med.Sci.
Professor of Child and Adolescent Psychiatry
Developmental Psychiatry Section
Department of Psychiatry
Cambridge University
Cambridge, England

Ian M. Goodyer is Professor of Child and Adolescent Psychiatry, Fellow of Wolfson College and Head of the Developmental Psychiatry Section in the Department of Psychiatry at the University of Cambridge Clinical School, England. His research interests have included epidemiological, clinical and experimental investigations into the role of undesirable life events and psychoendocrine processes in the onset, maintenance and outcome of unipolar depressions in young people. He has published three books and over 100 articles in these areas. He is general editor of the Cambridge Child Psychiatry series and is also co-director of the Cambridge Language and Speech Project, a 10 year longitudinal study of children with specific language impairment. He is Secretary-General of the International Association of Child and Adolescent Psychiatry. In 1997 he was awarded the Nathan Cummings Foundation Prize by the American Academy of Child and Adolescent Psychiatry for published research in the field of depression in young people. In 1999 he was elected to a Fellowship of the Academy of Medical Sciences of Great Britain.


NOREEN A. REILLY-HARRINGTON, Ph.D.
Instructor in Psychology
Harvard Medical School
Clinical Assistant in Psychology
Massachusetts General Hospital
Department of Psychiatry
Boston, Massachusetts

Noreen A. Reilly-Harrington, PhD is an Instructor in Psychology at Harvard Medical School and is on the staff of the Harvard Bipolar Research Program at Massachusetts General Hospital. She is a graduate of University of Pennsylvania and Temple University. Dr. Reilly-Harrington is a Founding Fellow of the Academy of Cognitive Therapy and has received research awards from the Society for Research in Psychopathology, the Association for the Advancement of Behavior Therapy, and Massachusetts General Hospital for her work examining the role of life stress and cognition on the course of bipolar mood disorders. She has lectured both nationally and internationally on the topic of cognitive behavioral therapy for bipolar disorder and is a Pathway Leader for the National Institute of Mental Health's Systematic Treatment Enhancement Program for Bipolar Disorder, the largest study of bipolar disorder ever conducted. She is also a co-author of a recent book entitled “Bipolar Disorder: A Cognitive Therapy Approach.”


PAUL HARRISON, M.D., M.R.C.PSYCH.
Reader and Honorary Consultant Psychiatrist
University Department of Psychiatry
Warneford Hospital
Oxford, United Kingdom

Paul Harrison, M.D., M.R.C.Psych. received a first class degree in physiological sciences from Oxford in 1982 and qualified in medicine in 1985. I trained in psychiatry in Oxford and London, and spent three years as a research fellow at St. Mary’s Hospital Medical school, London, investigating gene expression in Alzheimer’s disease. After receiving his research degree, he returned to Oxford in 1991 as a lecturer and established a laboratory for molecular psychiatry research. He became a Wellcome Trust Senior Research Fellow in 1995, a University Reader in 1997, and a Professor in 2000. He has clinical and teaching duties in addition to running a research group. The research is directed at molecular, genetic, and neuropathological aspects of schizophrenia and mood disorder, as well as relevant experimental models. In 1998, he was awarded the CINP/Paul Janssen Schizophrenia Prize, and in 1999 the British Association for Psychopharmacology Senior Clinical Psychopharmalogist Prize. He is on the Editorial Board of Neuroscience and Biological Psychiatry. Research support is provided by a Centre Award from the Stanley Foundation, and grants from the Wellcome Trust and the Medical Research Council.


MARTHA HELLANDER
Executive Director
Child and Adolescent Bipolar Foundation
Wilmette, Illinois

Martha Hellander, J.D., of Wilmette, Illinois, began leading on-line parent support groups on the Internet in 1996. She is co-founder and executive director of the Child and Adolescent Bipolar Foundation (CABF), a national, not-for-profit organization of providing information, support and advocacy for families raising children diagnosed with, or at risk for, bipolar disorder. CABF’s interactive web site, www.bpkids.org, offers online support groups, message boards and chat rooms, a support groups database and a database of professional members to help families in the U.S. and abroad find quality services and support.


STEVEN E. HYMAN, MD
Director, National Institute of Mental Health
Bethesda, Maryland

Steven E. Hyman, MD is Director of the National Institute of Mental Health (NIMH), the component of the National Institutes of Health charged with generating the knowledge needed to understand, treat, and prevent mental illness. Under Dr. Hyman's leadership, NIMH has heightened the priority it gives to four broad areas: (1) fundamental research on brain, behavior and genetics; (2) rapid translation of basic discoveries into research on mental disorders; (3) research that directly impacts the treatment of individuals with mental disorders, including clinical trials and studies of treatment and preventive interventions in “real world” settings; and (4) research on child development and childhood mental disorders. Dr. Hyman continues to direct an active research program in molecular neurobiology on the NIH campus (Bethesda, MD), focused on how neurotransmitters, especially dopamine alter the expression of genes in the striatum and thereby produce long term changes in neural function that can influence behavior.

Prior to his position at NIMH, Dr. Hyman was Professor of Psychiatry at Harvard Medical School and Director of Psychiatry Research at Massachusetts General Hospital in Boston. He also taught neurobiology at Harvard Medical School and was the first faculty Director of Harvard University's Interfaculty Initiative in Mind, Brain, and Behavior. In addition to his scientific writings, Dr. Hyman has authored and edited several widely used clinical texts. He serves on several review and advisory boards including the Riken Brain Sciences Institute in Japan, the Max Planck Institute in Germany, and the Howard Hughes Medical Institute in the United States. Dr. Hyman received his BA from Yale in 1974 (summa cum laude), and his MA from the University of Cambridge in 1976, where he was a Mellon fellow studying the history and philosophy of science. He received his MD from Harvard Medical School (cum laude) in 1980. Following an internship in Medicine at Massachusetts General Hospital (MGH), a residency in psychiatry at McLean Hospital, and a clinical fellowship in neurology at MGH, he was postdoctoral fellow at Harvard in molecular biology. Among his many awards and honors, Dr. Hyman is an elected member of the Institute of Medicine and recipient of the Distinguished Service Award from the National Alliance for the Mentally Ill.


HILKKA KÄRKKÄINEN
Master of Social Sciences
Helsinki University
Executive Director of AFFINITY
Finnish Central Association for Mental Health
Helsinki, Finland

Mrs. Hilkka Kärkkäinen has been the Executive Director of AFFINITY since 1998. AFFINITY is a patient organization with 150 local associations and some 15,000 individual members. Before her present position in AFFINITY Hilkka Kärkkäinen made a career mainly in the public sector in municipalities carrying out various duties in social sector for the City of Helsinki and for the Probation and Prison After Care Association in Helsinki. The last twelve years before her present job, Hilkka Kärkkäinen was working for the City of Espoo as an Office Manager. She was elected a President of GAMIAN-Europe in 1999 and has been a Vice-President since the year 2000.


PAUL E. KECK, JR., M.D.
Professor and Vice Chairman for Research
Deparment of Psychiatry
University of Cincinnati College of Medicine
Cincinnati, Ohio

Paul E. Keck, Jr., MD, is Professor of Psychiatry and Pharmacology and Vice Chairman for Research, Department of Psychiatry, University of Cincinnati College of Medicine. Dr. Keck is also Co-Director of the Biological Psychiatry Program, affiliated with the University of Cincinnati Medical Center. The Biological Psychiatry Program conducts research regarding the nosology, biology, course of illness, genetics, and treatment of bipolar disorder. In addition, the Program is a center for the study of new medicines to treat mood, anxiety, psychotic, eating, psychosomatic and impulse controls disorders.

A graduate of Dartmouth College, Dr. Keck received his MD from the Mount Sinai School of Medicine, New York, NY. He served his internship in Internal Medicine at the Beth Israel Medical Center in New York and completed his residency training in Psychiatry at McLean Hospital, Belmont, MA. Dr. Keck remained on faculty at McLean and Harvard Medical School before joining the faculty at the University of Cincinnati in 1991.

Dr. Keck is the author of over 350 scientific papers and abstracts in leading medical journals. He has also contributed over 90 reviews and chapters to major psychiatric textbooks. Dr. Keck is the editor of the book Managing Depressive Symptoms in Schizophrenia. He serves on the editorial boards of 6 journals. He also served on the American Psychiatric Association’s Workgroup to Develop Practice Guidelines for Treatment of Patients with Bipolar Disorders and currently serves on the APA Institute for Research and Education.

Dr. Keck is the recipient of numerous honors, including the Gerald Klerman Young Investigator Award from the National Depressive and Manic-Depressive Association (NDMDA); the Exemplary Psychiatrist Award from the National Alliance of the Mentally Ill (NAMI); the Philip Isenberg Teaching Award from Harvard Medical School; the Nancy C A Roeske Certificate for medical student education from the American Psychiatric Association; the Wyeth-Ayerst AADPRT Mentorship Award; two Communicator Awards for Continuing Medical Education; the Outstanding Physician Partner Award of the Postgraduate Institute for Medicine; and two Golden Apple Teaching Awards from the University of Cincinnati College of Medicine.

He is listed as one of the Best Doctors in Cincinnati by Cincinnati Magazine; The Best Doctors in America, a directory of the top one percent of physicians in the United States as rated by their peers; and as one of the nation’s Best Mental Health Experts by Good Housekeeping Magazine. Dr. Keck is also the Director of Scientific Development for the Neuroleptic Malignant Syndrome Information Service (NMSIS).


ATHANASIO KOUKOPOULOS, M.D.
Director, Centro Lucio Bini
Chief, Medical Staff
Clinica Belvedere Montello
Rome, Italy

Dr. Koukopoulos is the Director of the Centro Lucio Bini, a center for the treatment and the study of psychiatric conditions and especially of affective disorders, that he and other colleagues founded in 1976 and was Chief of the Medical Staff of the Clinica Belvedere Montello, a psychiatric in-patient private hospital in Rome, from 1963 to1998.

His main activity is the examination and treatment of psychiatric patients with a particular interest in Affective Disorders. In addition to his clinical activity, he has been performing clinical research into the course of Manic-Depressive Illness and the pattern of the manic-depressive cycle.

He is also conducting studies on manic-depressive temperament and its importance in the genesis of affective disorders and their course.

Related to the above issues have been other lines of research, like the response to prophylactic lithium treatment and the increase of bipolarity, frequency of recurrences, and mixed states following antidepressant drug treatments. The temperament, the previous course, and the concomitant factors of rapid cyclicity, have been an important part of his work for more than twenty years.


ROBERT A. KOWATCH, M.D.
Professor of Psychiatry and Pediatrics
University of Cincinnati Medical Center
Director, Child and Adolescent Mood Disorders Program
Children’s Hospital Medical Center of Cincinnati
Cincinnati, Ohio

Dr. Kowatch received his medical degree in 1980 and completed a residency in general psychiatry at the University of Pennsylvania Hospital in Philadelphia. He completed a fellowship in child and adolescent psychiatry at Hahnemann University in Philadelphia. He is board certified in general psychiatry, child and adolescent psychiatry, and sleep disorders medicine.

In 1995, he was awarded an NIMH, Child and Adolescent Clinical Mental Award which he completed at the University of Texas Southwestern Medical Center at Dallas. In September of 2000 he moved to Cincinnati where he is a professor of psychiatry and pediatrics at the University of Cincinnati Medical Center and Children’s Hospital Medical Center.

His research interests are in the treatment of child and adolescent bipolar disorders and the neurobiology of these disorders. He is the principal coordinating investigator of a recently funded, NIMH, multi-site, collaborative trial (1 RO1 MH63632-01) which is studying the efficacy of lithium and sodium divalproex in bipolar children and adolescents. He also is studying the neurobiology of affective lability of bipolar children and adolescents using functional MRI and various affective probes.


DAVID J. KUPFER, M.D.
Thomas Detre Professor and Chairman
Department of Psychiatry
Professor of Neuroscience
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

David J. Kupfer, M.D., Thomas Detre Professor and Chairman of the Department of Psychiatry and Professor of Neuroscience at the University of Pittsburgh School of Medicine, received his bachelor (magna cum laude) and M.D. degrees from Yale University. Following completion of an internship, Dr. Kupfer continued his postgraduate clinical and research training at the Yale New Haven Hospital and at the National Institute of Mental Health (NIMH). In 1969, he was appointed an assistant professor of psychiatry at Yale University School of Medicine. Dr. Kupfer joined the faculty at the University of Pittsburgh in 1973 as an associate professor of psychiatry and director of research and research training at Western Psychiatric Institute and Clinic. He was promoted to professor of psychiatry in 1975 and became chairman of the department in 1983. As Thomas Detre Professor and Chairman of the Department of Psychiatry and Director of Research at WPIC, he oversees the coordination and expansion of investigations among the department's almost 200 faculty. He has promoted widespread collaborations between clinical investigators in psychiatry and those in more basic neurosciences. These studies are not limited to depression and other mood disorders but encompass virtually every psychiatric disorder and every age group, from infants to the "oldest old." Under Dr. Kupfer's direction, WPIC has become one of the nation's preeminent university-based psychiatric centers as evidenced by the quality and number of publications as well as the amount of peer-reviewed federal funding for mental health research.

For more than twenty years, Dr. Kupfer's research has focused primarily on the conceptualization, diagnosis, and treatment of mood disorders. He has written more than 750 articles, books, and book chapters that examine the use of medication in recurrent depression, the causes of depression, and the relationship between biomarkers and depression.

In recognition of his contributions to the field, Dr. Kupfer has been the recipient of numerous awards and honors including the A.E. Bennett Research Award in Clinical Science (1975), the Anna-Monika Foundation Prize (1977), the Daniel H. Efron Award (1979), the Twenty-Sixth Annual Award of the Institute of Pennsylvania Hospital in Memory of Edward A. Strecker, M.D. (1989), the William R. McAlpin, Jr. Research Achievement Award (1990), the 1993 American Psychiatric Association Award for Research in Psychiatry, the First Isaac Ray Decade of Excellence Award (1994), the Twelfth Annual Edward J. Sachar Award (1996), the 1996 Gerald Klerman Lifetime Research Award (jointly with Dr. Ellen Frank), the Institute of Medicine’s 1998 Rhoda and Bernard Sarnat International Prize in Mental Health, and the American Psychopathological Association’s 1999 Joseph Zubin Award (jointly with Dr. Ellen Frank). He was elected to the Institute of Medicine of the National Academy of Sciences in 1990.


FOUZIA LAGHRISSI-THODE, M.D.
CNS Director
New Medicine Strategy
F. Hoffmann-La Roche Ltd.
Pharmaceutical Division
Strategic Marketing and Business Development
Basel, Switzerland

Since 2000, Fouzia Laghrissi-Thode, M.D. holds, at F. Hoffmann-La Roche (Basel, Switzerland) a CNS Leader Position in the New Medicines Strategy Department. She also holds, since 1992, an appointment as an Assistant Professor in Psychiatry at Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center (USA). Prior to joining F. Hoffmann-La Roche, she worked for three years in the International Clinical Research Nervous System Department of Novartis Pharma (Basel, Switzerland). After graduating in Medicine at the University of Tours (France) in 1987 and completing residencies in General and Internal Medicine, she specialized in Psychiatry and received her European certification in 1992. As a Principal Investigator she conducted a number of studies in depressed elderly and medically ill patients, and actively participated as co-investigator in the research conducted by the NIMH CRC for the Study of Affective Disorders and Late Life Mood Disorders.


THOMAS P. LAUGHREN, M.D.
Team Leader, Psychiatric Drug Products
Division of Neuropharmacological Drug Products
Food and Drug Administration
Rockville, Maryland

Dr. Laughren is currently Team Leader for the Psychiatric Drug Products Group in the Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research at FDA. Prior to coming to FDA in September 1983, Dr. Laughren was affiliated with the VA Medical Center in Providence, Rhode Island, and was on the faculty of the Brown University Program in Medicine. He received his medical degree from the University of Wisconsin in Madison, Wisconsin, and he also completed residency training in psychiatry at the University of Wisconsin. Dr. Laughren is board certified in general psychiatry.


BARRY D. LEBOWITZ, Ph.D.
Chief, Adult and Geriatric Treatment and
Preventive Interventions Research Branch
National Institute of Mental Health
Bethesda, Maryland

Dr. Barry Lebowitz is Chief of the Adult and Geriatric Treatment and Preventive Interventions Research Branch of the National Institute of Mental Health and an adjunct professor in the Department of Psychiatry of the Georgetown University School of Medicine. A native of Boston, Massachusetts, Dr. Lebowitz is a graduate of McGill University and Cornell University. He was elected a Fellow of the Gerontological Society of America and an Honorary Fellow of the American Psychiatric Association and the American Association for Geriatric Psychiatry. Dr. Lebowitz serves on the editorial boards of a number of scientific and professional journals and is the author of many books and articles in mental health and aging.


LYDIA LEWIS
Executive Director
National Depressive and Manic-Depressive Association
Chicago, Illinois

Lydia Lewis became Executive Director of the National Depressive and Manic-Depressive Association (National DMDA) in June 1997. Her primary responsibility is to position the organization as a leading resource for patients, family members, professionals, legislators and the media who want (or need) to know more about mood disorders and their treatments. Also serving as spokesperson for the organization, Ms. Lewis has spoken at the invitation of various organizations, including the American College of Neuropsychopharmacology, the American Psychological Association, the American Psychiatric Association, the Society for Biological Psychiatry, the National Institute of Mental Health, Yale University School of Medicine and the National Foundation for Brain Research. She is a member of the oversight committees of several large NIMH clinical trials including STEP-BD, STAR*D, TADS and the hypericum (St. John’s Wort) trials. In addition she was a charter member of the National Institutes of Health Director’s Council of Public Representatives. She holds a Bachelor of Arts in psychology from the State University of New York at Buffalo. One of her proudest accomplishments has been her willingness to do life-long battle with depression.

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