LEADS FROM STUDIES OF MOOD STABILIZERS
Cade’s Conclusions - 1949
PPT Slide
Design of Lithium Normal Volunteer Study
Effects of 2 Week Lithium Administration on Adenylyl Cyclase Activity in Healthy Volunteers
Lithium and G Proteins
Evidence for Lithum’s Effects on G Proteins
Relevance of G Protein Changes for the Long-Term Treatment of Bipolar Affective Disorder
Design of Study
Evidence for Lithium’s Effects on Protein Kinase C
Evidence for Lithium’s Effects on Protein Kinase C (Cont’d)
Acute Effects of Valproic Acid
Effective Antimanic Treatments Which Affect Protein Kinase C Function
Transfection of a Reporter Gene into C6 Glioma Cells
Effects of VPA on the Expression of the Luciferase Gene in C6 Cells
Effects of Lithium on the Expression of Luciferase Gene in C6 Cells
Why Target G Protein Subunits for Novel CNS Drugs?
Why Target G Protein Subunits for Novel CNS Drugs? (Cont’d)
Is Manipulation of G Protein Function Compatible with Life?
Protein-Protein Interactions Known to Regulate the Activity of G Protein " Subunits
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