ALLELE DESIGNATIONS: 1854352A/G A=1 G=2 1360020G/T G=1 T=2 -1438A/G A=1 G=2 74C/A(Thr25Asn) C=1 A=2 102C/T(Ser34Ser) C=1 T=2 516C/T(Asp172Asp) C=1 T=2 1354C/T(His452Tyr) C=1 T=2 1018579A/G A=1 G=2 1018578T/G T=1 G=2 RESUTLTS Marker 1854352A/G trans untrans Chi2 p-val 1854352A/G- Allele 1 15 16 0.03 0.857462 1854352A/G- Allele 2 16 15 0.03 0.857462 Marker 1360020G/T trans untrans Chi2 p-val 1360020G/T- Allele 1 13 20 1.48 0.223017 1360020G/T- Allele 2 20 13 1.48 0.223017 Marker -1438A/G trans untrans Chi2 p-val -1438A/G- Allele 1 13 19 1.12 0.288844 -1438A/G- Allele 2 19 13 1.12 0.288844 Marker 74C/A(Thr25Asn) trans untrans Chi2 p-val 74C/A(Thr25Asn) - Allele 1 5 0 5.00 0.025347 + 74C/A(Thr25Asn) - Allele 2 0 5 5.00 0.025347 - Marker 102C/T(Ser34Ser) trans untrans Chi2 p-val 102C/T(Ser34Ser)- Allele 1 18 18 0.00 1.000000 102C/T(Ser34Ser)- Allele 2 18 18 0.00 1.000000 Marker 516C/T(Asp172Asp) trans untrans Chi2 p-val 516C/T(Asp172Asp) - Allele 1 3 1 1.00 0.317311 516C/T(Asp172Asp) - Allele 2 1 3 1.00 0.317311 Marker 1354C/T(His452Tyr) trans untrans Chi2 p-val 1354C/T(His452Tyr)- Allele 1 7 0 7.00 0.008151 ++ 1354C/T(His452Tyr)- Allele 2 0 7 7.00 0.008151 -- Marker 1018579A/G trans untrans Chi2 p-val 1018579A/G- Allele 1 13 18 0.81 0.369171 1018579A/G- Allele 2 18 13 0.81 0.369171 Marker 1018578T/G trans untrans Chi2 p-val 1018578T/G- Allele 1 17 18 0.03 0.865772 1018578T/G- Allele 2 18 17 0.03 0.865772 Markers 1 and 2 trans untrans Chi2 p-val (1854352A/G - 1360020G/T) Haplotype: 1 1 0 2 2.00 0.157299 Haplotype: 1 2 9 9 0.00 1.000000 Haplotype: 2 1 8 10 0.22 0.637352 Haplotype: 2 2 9 5 1.14 0.285049 Markers 2 and 3 trans untrans Chi2 p-val (1360020G/T - -1438A/G) Haplotype: 1 1 8 8 0.00 1.000000 Haplotype: 1 2 4 4 0.00 1.000000 Haplotype: 2 1 0 4 4.00 0.045500 - Haplotype: 2 2 9 5 1.14 0.285049 Markers 3 and 4 trans untrans Chi2 p-val (-1438A/G - 74C/A(Thr25Asn)) Haplotype: 1 1 9 11 0.20 0.654721 Haplotype: 1 2 0 4 4.00 0.045500 - Haplotype: 2 1 14 8 1.64 0.200825 Markers 4 and 5 trans untrans Chi2 p-val (74C/A(Thr25Asn) - 102C/T(Ser34Ser)) Haplotype: 1 1 13 11 0.17 0.683091 Haplotype: 1 2 13 11 0.17 0.683091 Haplotype: 2 1 0 2 2.00 0.157299 Haplotype: 2 2 0 2 2.00 0.157299 Markers 5 and 6 trans untrans Chi2 p-val (102C/T(Ser34Ser) - 516C/T(Asp172Asp)) Haplotype: 1 1 13 12 0.04 0.841481 Haplotype: 1 2 0 1 1.00 0.317311 Haplotype: 2 1 12 11 0.04 0.834827 Haplotype: 2 2 0 1 1.00 0.317311 Markers 6 and 7 trans untrans Chi2 p-val (516C/T(Asp172Asp) - 1354C/T(His452Tyr)) Haplotype: 1 1 9 0 9.00 0.002700 ++ Haplotype: 1 2 0 6 6.00 0.014306 - Haplotype: 2 1 0 2 2.00 0.157299 Haplotype: 2 2 0 1 1.00 0.317311 Markers 7 and 8 trans untrans Chi2 p-val (1354C/T(His452Tyr) - 1018579A/G) Haplotype: 1 1 10 9 0.05 0.818546 Haplotype: 1 2 12 7 1.32 0.251349 Haplotype: 2 1 0 5 5.00 0.025347 - Haplotype: 2 2 0 1 1.00 0.317311 Markers 8 and 9 trans untrans Chi2 p-val (1018579A/G - 1018578T/G) Haplotype: 1 1 7 8 0.07 0.796253 Haplotype: 1 2 0 2 2.00 0.157299 Haplotype: 2 2 8 5 0.69 0.405381 Markers 1 and 2 and 3 trans untrans Chi2 p-val (1854352A/G - 1360020G/T - -1438A/G) Haplotype: 1 1 1 0 2 2.00 0.157299 Haplotype: 1 2 1 0 3 3.00 0.083264 Haplotype: 1 2 2 3 5 0.50 0.479500 Haplotype: 2 1 1 8 4 1.33 0.248213 Haplotype: 2 1 2 4 4 0.00 1.000000 Haplotype: 2 2 1 1 2 0.33 0.563703 Haplotype: 2 2 2 7 3 1.60 0.205903 Markers 2 and 3 and 4 trans untrans Chi2 p-val (1360020G/T - -1438A/G - 74C/A(Thr25Asn)) Haplotype: 1 1 1 8 7 0.07 0.796253 Haplotype: 1 1 2 0 1 1.00 0.317311 Haplotype: 1 2 1 4 4 0.00 1.000000 Haplotype: 2 1 1 0 3 3.00 0.083264 Haplotype: 2 1 2 0 1 1.00 0.317311 Haplotype: 2 2 1 9 5 1.14 0.285049 Markers 3 and 4 and 5 trans untrans Chi2 p-val (-1438A/G - 74C/A(Thr25Asn) - 102C/T(Ser34Ser)) Haplotype: 1 1 1 1 5 2.67 0.102470 Haplotype: 1 1 2 9 5 1.14 0.285049 Haplotype: 1 2 1 0 2 2.00 0.157299 Haplotype: 1 2 2 0 2 2.00 0.157299 Haplotype: 2 1 1 10 7 0.53 0.466854 Haplotype: 2 1 2 2 1 0.33 0.563703 Markers 4 and 5 and 6 trans untrans Chi2 p-val (74C/A(Thr25Asn) - 102C/T(Ser34Ser) - 516C/T(Asp172Asp)) Haplotype: 1 1 1 14 11 0.36 0.548506 Haplotype: 1 1 2 0 1 1.00 0.317311 Haplotype: 1 2 1 13 10 0.39 0.531615 Haplotype: 1 2 2 0 1 1.00 0.317311 Haplotype: 2 1 1 0 2 2.00 0.157299 Haplotype: 2 2 1 0 2 2.00 0.157299 Markers 5 and 6 and 7 trans untrans Chi2 p-val (102C/T(Ser34Ser) - 516C/T(Asp172Asp) - 1354C/T(His452Tyr)) Haplotype: 1 1 1 11 10 0.05 0.827259 Haplotype: 1 2 1 0 1 1.00 0.317311 Haplotype: 2 1 1 11 6 1.47 0.225253 Haplotype: 2 1 2 0 4 4.00 0.045500 - Haplotype: 2 2 1 0 1 1.00 0.317311 Markers 6 and 7 and 8 trans untrans Chi2 p-val (516C/T(Asp172Asp) - 1354C/T(His452Tyr) - 1018579A/G) Haplotype: 1 1 1 10 9 0.05 0.818546 Haplotype: 1 1 2 12 6 2.00 0.157299 Haplotype: 1 2 1 0 5 5.00 0.025347 - Haplotype: 2 1 2 0 1 1.00 0.317311 Haplotype: 2 2 2 0 1 1.00 0.317311 Markers 7 and 8 and 9 trans untrans Chi2 p-val (1354C/T(His452Tyr) - 1018579A/G - 1018578T/G) Haplotype: 1 1 1 7 7 0.00 1.000000 Haplotype: 1 1 2 0 2 2.00 0.157299 Haplotype: 1 2 2 8 4 1.33 0.248213 Haplotype: 2 1 1 0 1 1.00 0.317311 Haplotype: 2 2 2 0 1 1.00 0.317311 Markers 1 - 2 - 3 - 4 trans untrans Chi2 p-val (1854352A/G - 1360020G/T - -1438A/G - 74C/A(Thr25Asn)) Haplotype: 1 1 1 1 0 1 1.00 0.317311 Haplotype: 1 1 1 2 0 1 1.00 0.317311 Haplotype: 1 2 1 1 0 2 2.00 0.157299 Haplotype: 1 2 1 2 0 1 1.00 0.317311 Haplotype: 1 2 2 1 3 5 0.50 0.479500 Haplotype: 2 1 1 1 8 4 1.33 0.248213 Haplotype: 2 1 2 1 4 4 0.00 1.000000 Haplotype: 2 2 1 1 1 2 0.33 0.563703 Haplotype: 2 2 2 1 7 3 1.60 0.205903 Markers 2 - 3 - 4 - 5 trans untrans Chi2 p-val (1360020G/T - -1438A/G - 74C/A(Thr25Asn) - 102C/T(Ser34Ser)) Haplotype: 1 1 1 1 1 1 0.00 1.000000 Haplotype: 1 1 1 2 7 4 0.82 0.365712 Haplotype: 1 1 2 2 0 1 1.00 0.317311 Haplotype: 1 2 1 1 2 4 0.67 0.414216 Haplotype: 1 2 1 2 2 0 2.00 0.157299 Haplotype: 2 1 1 1 0 4 4.00 0.045500 - Haplotype: 2 1 1 2 1 0 1.00 0.317311 Haplotype: 2 1 2 1 0 1 1.00 0.317311 Haplotype: 2 2 1 1 7 4 0.82 0.365712 Haplotype: 2 2 1 2 0 1 1.00 0.317311 Markers 3 - 4 - 5 - 6 trans untrans Chi2 p-val (-1438A/G - 74C/A(Thr25Asn) - 102C/T(Ser34Ser) - 516C/T(Asp172Asp)) Haplotype: 1 1 1 1 1 5 2.67 0.102470 Haplotype: 1 1 2 1 9 4 1.92 0.165518 Haplotype: 1 1 2 2 0 1 1.00 0.317311 Haplotype: 1 2 1 1 0 2 2.00 0.157299 Haplotype: 1 2 2 1 0 2 2.00 0.157299 Haplotype: 2 1 1 1 11 7 0.89 0.345779 Haplotype: 2 1 1 2 0 1 1.00 0.317311 Haplotype: 2 1 2 1 2 1 0.33 0.563703 Markers 4 - 5 - 6 - 7 trans untrans Chi2 p-val (74C/A(Thr25Asn) - 102C/T(Ser34Ser) - 516C/T(Asp172Asp) - 1354C/T(His452Tyr)) Haplotype: 1 1 1 1 12 9 0.43 0.512691 Haplotype: 1 1 2 1 0 1 1.00 0.317311 Haplotype: 1 2 1 1 12 5 2.88 0.089555 Haplotype: 1 2 1 2 0 4 4.00 0.045500 - Haplotype: 1 2 2 1 0 1 1.00 0.317311 Haplotype: 2 1 1 1 0 2 2.00 0.157299 Haplotype: 2 2 1 1 0 2 2.00 0.157299 Markers 5 - 6 - 7 - 8 trans untrans Chi2 p-val (102C/T(Ser34Ser) - 516C/T(Asp172Asp) - 1354C/T(His452Tyr) - 1018579A/G) Haplotype: 1 1 1 1 5 7 0.33 0.563703 Haplotype: 1 1 1 2 7 5 0.33 0.563703 Haplotype: 2 1 1 1 7 2 2.78 0.095581 Haplotype: 2 1 1 2 4 4 0.00 1.000000 Haplotype: 2 1 2 1 0 4 4.00 0.045500 - Haplotype: 2 2 1 2 0 1 1.00 0.317311 Markers 6 - 7 - 8 - 9 trans untrans Chi2 p-val (516C/T(Asp172Asp) - 1354C/T(His452Tyr) - 1018579A/G - 1018578T/G) Haplotype: 1 1 1 1 7 7 0.00 1.000000 Haplotype: 1 1 1 2 0 2 2.00 0.157299 Haplotype: 1 1 2 2 8 3 2.27 0.131668 Haplotype: 1 2 1 1 0 1 1.00 0.317311 Haplotype: 2 1 2 2 0 1 1.00 0.317311 Haplotype: 2 2 2 2 0 1 1.00 0.317311 *********************************** tdt for 74C/A(Thr25Asn) - 1354C/T(His452Tyr) npl:7> tdt2 1 Markers 4 and 7 trans untrans Chi2 p-val (74C/A(Thr25Asn) - 1354C/T(His452Tyr)) Haplotype: 1 1 12 0 12.00 0.000532 +++ Haplotype: 1 2 0 7 7.00 0.008151 -- Haplotype: 2 1 0 5 5.00 0.025347 -