Research into the causes of Schizophrenia, Bipolar Disorder, and Related Illnesses

Peer Reviewed Scientific papers by Dr. Nimgaonkar (since 1990)


PUBLICATIONS FOLLOWING PEER REVIEW:

 

1.      Nimgaonkar VL, Green AR, Cowen PJ, Heal DJ, Grahame-Smith DG and Deakin JFW (1983).  Studies on the mechanisms by which clenbuterol, a B-adrenoceptor agonist, enhances 5-HT-mediated behavior and increases metabolism of 5-HT in the brain of the rat.  Neuropharmacology, 22, 739-749.

2.      Green AR, Johnson P and Nimgaonkar VL (1983).  Increased 5-HT receptor number as a probable explanation for the enhanced 5-hydroxytryptamine-mediated behavior following repeated electroconvulsive shock administration to rats.  British Journal of Pharmacology, 80, 173-177.

3.      Green AR, Johnson P and Nimgaonkar VL (1983).  Interactions of B-adrenoceptor agonists and antagonists with the 5-hydroxytryptamine2 (5HT2) receptor.  Neuropharmacology, 22, 657-660.

4.      Green AR, Heal DJ, Johnson P, Laurence BE and Nimgaonkar VL (1983).  Antidepressant treatments:  Effects in rodents on dose-response curves of 5-hydroxytryptamine and dopamine-mediated behaviors and 5-HT2 receptors in frontal cortex.  British Journal of Pharmacology, 80, 277-285.

5.      Nimgaonkar VL, Goodwin GM, Davies CL and Green AR (1985).  Down regulation of rat cortical B-adrenoceptors by repeated administration of desipramine, ECS and clenbuterol requires 5-HT neurones but not 5-HT.  Neuropharmacology, 24, 279-283.

6.      Green AR, Johnson P, Mountford JA, and Nimgaonkar VL (1985).  Some anticonvulsant drugs alter monoamine-mediated behaviors in mice in ways similar to electroconvulsive shock; implications for antidepressant therapy.  British Journal of Pharmacology, 84, 337-346.

7.      Nimgaonkar VL, Heal DJ, Davies CL and Green AR (1987).  Studies on rat brain catecholamine synthesis and B-adrenoceptor number following administration of electroconvulsive shock, desipramine and clenbuterol.  Journal of Neural Transmission, 65, 245-249.

8.      Whatley S, Nimgaonkar VL, and Rajendran MY (1987).  The effect of haloperidol on protein synthesis in human lymphocytes.  Biochemical Society Transactions, 15, 688-689.

9.      Nimgaonkar VL Wessely S, Tune LE and Murray RM (1988).  Response to drugs in schizophrenia:  the influence of family history, obstetric complications and ventricular enlargement.  Psychological Medicine, 18, 583-592.

10.  Nimgaonkar VL, Wessely S, and Murray RM (1988).  Prevalence of familiality, obstetric complications and structural brain damage in schizophrenic patients.  British Journal of Psychiatry, 153, 191-197.

11.  Nimgaonkar VL, Farrell M (1988).  Reasons for non-attendance at a child guidance clinic.  Child:  care, health, development. 14, 387-393.

12.  Nimgaonkar VL, Whatley SA (1990).  A stereospecific, therapeutically relevant effect of antipsychotic drugs on protein synthesis in human mononuclear cells.  Journal of Neurochemistry.  54, 1934-1940.

13.  Nimgaonkar VL, Rajendran MY, Whatley SA (1990).  A putative biological marker for clinical response to drugs in schizophrenia.  Psychiatry Research. 32, 95-97.

14.  Nimgaonkar VL, Ganguli R. Rudert WA, Vavassori C, Rabin BS, Trucco M (1992). A negative association of schizophrenia with an allele of the HLA DQB1 gene among African-Americans. Schizophrenia Research, 8:199-209.

15.  Nimgaonkar VL, Ganguli, R, Washington, SS, Chakravarti, A  (1992). Schizophrenia and porphobilinogen deaminase gene polymorphisms: an association study.  Schizophrenia Research. 8: 51-58.

16.  Nimgaonkar VL, Scott JA, Brar JS, Ganguli R, Chakravarti A (1993). Co-occurrence of schizophrenia and Treacher Collins syndrome.  American Journal of Medical Genetics, 48, 156 - 158.

17.  Nimgaonkar VL, Zhang, XR, Caldwell JG, Ganguli R, Chakravarti A (1993).  An association study of schizophrenia with dopamine D3 receptor gene polymorphisms: probable effects of family history of schizophrenia?  American Journal of Medical Genetics, 48, 214-217.

18.  Silver MA, Yang ZW, Ganguli R, Nimgaonkar VL (1994). An inhibitory effect of psychoactive drugs on proliferation of a human neuroblastoma cell line. Biological Psychiatry, 35, 824-826.

19.  Nimgaonkar VL, Yang ZW, Zhang XR, Brar JS, Chakravarti A, Ganguli R (1995). Association study of schizophrenia and the IL-2 receptor bchain gene. American Journal of Medical Genetics, 60, 448 - 451.

20.  Nimgaonkar VL, Rudert WA, Zhang XR, Tsoi WF, Trucco M, Saha N (1995). Further evidence for an association between schizophrenia and the HLA DQB1 gene locus. Schizophrenia Research, 18, 43-49.

21.  Nimgaonkar VL, Zhang XR, Brar JS, DeLeo M, Ganguli R (1995). Lack of association of schizophrenia with the neurotrophin-3 gene locus. Acta Psychiatrica Scandinavica, 92, 464 - 466.

22.  Chengappa KNR, Nimgaonkar VL, Bachert C, Yang ZW, Rabin BS, Ganguli R (1995). Obstetric complications and autoantibodies in schizophrenia. Acta Psychiatrica Scandinavica, 92, 270-273.

23.  Nimgaonkar VL, Zhang XR, Brar JS, DeLeo M, Ganguli R (1996).  5-HT2 receptor gene locus: association with schizophrenia or treatment response not detected.  Psychiatric Genetics, 6(1):23 - 28.

24.  Nimgaonkar VL, Sanders AR, Ganguli R, Zhang XR, Brar J, Hogge W, Fann WE, Patel PI, Chakravarti A (1996). Association study of schizophrenia and the dopamine D3 receptor gene locus in two independent samples. American Journal of Medical Genetics, 67, 505 - 514.

25.  Nimgaonkar VL, Ward SE, Agarde H, Weston N, Ganguli R (1997).  Fertility in schizophrenia: results from a contemporary United States cohort.  Acta Psychiatrica Scandinavica, 95:364 - 369.

26.  Nimgaonkar VL, Rudert WA, Zhang X, Trucco M, Ganguli R (1997).  Negative association of schizophrenia with HLA DQB1*0602: evidence from a second African-American cohort.  Schizophrenia Research, 23, 81 - 86.

27.  Mikesell MJ, Barron, YD, Nimgaonkar VL, Sobell JL, Sommer SS, McMurray CT (1997) No evidence for association of the Gly(247)->Asp Proenkephalin A mutation with schizophrenia. American Journal of Medical Genetics, 74 (2), 213 - 215.

28.  Jonsson E, Brene S, Zhang XR, Nimgaonkar VL, Tylec A, Schalling M, Sedvall G (1997) Schizophrenia and neurotrophin-3 alleles. Acta Psychiatrica Scandinavica, 95(5):414 - 419.

29.  Deshpande SN, Mathur MNL, Das SK, Bhatia T, Sharma SD, Nimgaonkar VL (1998). A Hindi version of the Diagnostic Interview for Genetic Studies.  Schizophrenia Bulletin, 24(3), 489-493.

30.  Jonsson E, Zhang F, Nimgaonkar VL, Rudert WA, Sedvall G (1998) Lack of association of schizophrenia with HLA DQB1 alleles in a Swedish sample.  Schizophrenia Research, 29(3):293-296.

31.  Chandy KG, Fantino E, Tong L, Kalman K, Gutman GA, Crocq M-A, Ganguli R, Nimgaonkar VL, Morris-Rosendahl D, Gargus JJ (1998)  hSKCa3, a susceptibility gene for schizophrenia and bipolar disorder.  Molecular Psychiatry, 3:32-37.

32.  Nimgaonkar VL, and Bennett PJ, Foroud TM, Hawi ZH, Jonsson E, Kalsi G, Krebs M-O, Labuda MC, Macciardi FM, Maziage M, Rietschel MDC, Shaw SH, Straub RE, Williams J (1998).  Chromosome 3 workshop report.  Psychiatric Genetics 8, 63-65.

33.  Rao D, Jonsson EG, Paus S, Ganguli R, Nothen M, Nimgaonkar VL (1998).  Schizophrenia and the serotonin transporter gene.  Psychiatric Genetics, 8(4):207 - 212.

34.  Sweet RA, Nimgaonkar VL, Kamboh MI, Lopez OL, Zhang F, DeKosky ST (1998).  Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer’s disease.  Archives of Neurology 55, 1335 - 1340.

35.  Nimgaonkar VL (1998).  Reduced fertility in schizophrenia:  Here to stay?  Acta Psychiatrica Scandinavica, 98, 348-353.

36.  Prasad S, Deshpande SN, Bhatia T, Wood J, Nimgaonkar VL, Thelma BK (1999).  An association study of schizophrenia among Indian families.  American Journal of Medical Genetics, 88, 298-300.

37.  Jonsson E, Nimgaonkar VL, Zhang, XR, Shaw SH, Chakravarti A, Crocq M-A, Sedvall GC (1999).  A trend for an association between schizophrenia and D3S1310, a marker in proximity to the dopamine D3 receptor gene.  American Journal of Medical Genetics, 88(4):352-357.

38.  Strauss J, Zhang XR, Barron Y, Ganguli R, Nimgaonkar VL (1999).  Lack of association between schizophrenia and a pancreatic phospholipase A-2 Gene (PLA2GIB) polymorphism.  Psychiatric Genetics, 9(3), 153-155.

39.  Chowdari KV, Nimgaonkar VL (1999).  Schizophrenia.  Genetica 21, Supp.2:8-13.

40.  Nimgaonkar VL, Fujiwara TM, Dutta M, Wood J, Gentry K, Maendel S, Morgan K, Eaton J (2000).  Low prevalence of psychoses among the Hutterites, an isolated religious community.  American Journal of Psychiatry 157(7):1065-1070.

41.  Chowdari KV, Wood J, Ganguli R, Gottesman II, Nimgaonkar VL (2000).  Lack of association between schizophrenia and a CAG repeat polymorphism of the hSKCa3 gene in a North Eastern US sample.  Molecular Psychiatry 5(3):237-238.

42.  Buervenich S, Carmine A, Arvidsson M, Xiang F, Zhang Z, Sydow O, Jonsson EG, Sedvall GC, Leonard S, Ross RG, Freedman R, Chowdari KV, Nimgaonkar VL, Perlman T, Anvret M, Olson L (2000).  NURR1 mutations in cases of schizophrenia and manic-depressive disorder.  American Journal of Medical Genetics 96(6):808-813.

43.  Gentry K, Nimgaonkar VL (2000).  Mitochondrial DNA variants in schizophrenia: association studies.  Psychiatric Genetics 10(1): 27-31.

44.  Davis S, Nimgaonkar VL (2001).  Impact of overlapping recruitment on linkage analysis of complex disorders: simulation studies. American Journal of Medical Genetics (Neuropsychiatric Genetics), 105(2):141-144.

45.  Semwal P, Prasad S, Bhatia T, Deshpande SN, Wood J, Nimgaonkar VL, Thelma BK (2001).  Family based association studies of monoaminergic gene polymorphisms among North Indians with schizophrenia.  Molecular Psychiatry 6:220-224.

46.  Chowdari  KV, Xu K, Zhang F, Ma C, Li T, Xie BY, Wood J, Trucco M, Tsoi W-F, Saha N, Rudert WA, Nimgaonkar VL (2001).  Immune related genetic polymorphisms and schizophrenia among the Chinese.  Human Immunology 62:714-724.

47.  Chowdari KV, Brandstaetter B, Semwal P, Bhatia T, Deshpande S, Reddy R, Wood J, Weinberg CR, Thelma BK, Nimgaonkar VL (2001).  Association studies of cytosolic phospholipase A2 polymorphisms and schizophrenia among two independent family-based samples.  Psychiatric Genetics  11:207-212.

48.  Wright P, Nimgaonkar VL, Donaldson PT, Murray RM (2001).  Schizophrenia and HLA:  a review.  Schizophrenia Research, 47(1):1-12.

49.  Brar LK, Brar JS, Deily NG, Wood JA, Reitz PM, Kupfer DJ, Nimgaonkar VL (2002). Can clinical features of Bipolar-1 Disorder be assessed reliably on the telephone?  Journal of Affective Disorders 71(1-3):221-227.

50.  Sweet RA, Nimgaonkar VL, Devlin B, Lopez OL, DeKosky ST (2002).  Increased familial risk of the psychotic phenotype of Alzheimer Disease.  Neurology 58(6):907-911.

51.  Baysal BE, Willett-Brozick1 JE, Badner JA, Corona W, Ferrell RE, Nimgaonkar VL, Detera-Wadleigh SD (2002).  A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family.  American Journal of Medical Genetics (Neurogenetics) 4(1):43-53.

52.  Chowdari KV, Mirnics K, Semwal P, Wood J, Lawrence E, Bhatia T, Deshpande SN, Thelma B. K, Ferrell RE, Middleton FA, Devlin B,  Levitt P, Lewis DA, Nimgaonkar VL (2002).  Association and linkage analyses of RGS4 polymorphisms in schizophrenia.  Human Molecular Genetics 11(12):1373-1380.

53.  Hammond L, Castanotto D, Rice SR, Nimgaonkar VL, Wirshing DA, Rossi JJ, Heston LL, Sobell JL (2002).  Alteration of branch site consensus sequence and enhanced pre-mRNA splicing of an NMDAR1 intron not associated with schizophrenia.  American Journal of Medical Genetics (Neuropsychiatric Genetics) 114(6):631-636.

54.  Prasad S, Semwal P, Deshpande S, Bhatia T, Nimgaonkar VL, Thelma BK (2002).  Molecular genetics of schizophrenia:  past, present and future.  Journal of Biosciences, 27(1 Suppl 1):35-52.

55.  Mansour HA, Alda M, Nimgaonkar VL (2002).  Pharmacogenetics of Bipolar Disorder.  Current Psychiatry Reports, 4(2):117-123.

56.  Jonsson EG, Flyckt L, Burgert E, Crocq M-A, Forslund K, Mattila-Evenden M, Rylander G, Asberg M, Nimgaonkar VL, Edman G, Bjerkenstedt L, Wiesel F-A, Sedvall GC (2003).  Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis.  Psychiatric Genetics 13(1):1-12.

57.  Carmine A, Buervenich S, Galter D, Jonsson EG, Sedvall GC, Sydow O, Farde L, Gustavsson JP, Bergman H, Chowdari KV, Nimgaonkar VL, Anvret M, Olson L (2003). NURR1 Promoter Polymorphisms: Parkinson’s Disease, Schizophrenia and Personality Traits.  American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 120B(1):51-57.

58.  Ranade  SS, Mansour H, Wood J, Chowdari KV, Brar LK, Kupfer DJ, Nimgaonkar VL (2003). Linkage and association between serotonin 2A receptor gene polymorphisms and Bipolar I Disorder. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 121B:28-34.

59.  Cook SE, Miyabara S, Bacanu S-A, Perez-Madrinan G, Lopez OL, Kaufer DI, Nimgaonkar VL, Wisniewski SR, DeKosky ST, Sweet RA (2003).  Psychotic symptoms in Alzheimer Disease: Evidence for subtypes.  The American Journal of Geriatric Psychiatry 11(4):406-413.

60.  Deshpande SN, Bhatia T, Wood J, Brar JS, Thelma BK, Ganguli R, Day R, Gottesman II, Nimgaonkar VL (2004).  Evaluation of familial influences on the course and severity of schizophrenia among US and Indian cases.  Social Psychiatry and Psychiatric Epidemiology 39:369-374.

61.  Bhatia T, Franzos, M A, Wood J A, Nimgaonkar V L,  Deshpande S N (2004).  Gender and procreation among patients with schizophrenia.  Schizophrenia Research.  68:387-394.

62.  Williams NM, Norton N, Williams H, Ekholm B, Hamshere ML, Lindblom Y, Chowdari KV, Cardno AG, Zammit S, Jones LA, Murphy KC, Sanders RD, McCarthy G, Gray MY, Jones G, Holmans P, Nimgaonkar V L, Adolfson R, Osby U, Terenius L, Sedvall G, O’Donovan M C, Owen M J (2004). A Systematic Genome-wide Linkage Study in 353 Sib Pairs with Schizophrenia. American Journal of Human Genetics. 73:1355-1367.

63.  Williams N M, Preece A, Spurlock G, Norton N, Williams H, McCreadie R G, Buckland P, Sharkey V, Chowdari K V, Zammit S, Nimgaonkar V L, Kirov G, Owen M J, O’Donovan M C (2004). Support for RGS4 as a susceptibility gene for schizophrenia.  Biological Psychiatry 55(2):192-195.

64.  Lee Y-S, Miller M, Hassett AC, Lee-Kim B-Y, Kim JJ, Haracznak M, Ranade S, Wood J, Reddy R, Kupfer DJ, Bontempo F, Nimgaonkar VL (2004).  von Willebrand’s disease and psychotic disorders: co-segregation and genetic associations.  Bipolar Disorders 6:150-155.

65.  Jönsson EG, Kaiser R, Brockmöller J, Nimgaonkar VL, Crocq M-A (2004). Meta-analysis of dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia. Psychiatric Genetics 14:9-12.

66.  Prasad S, Chowdari KV, Wood J, Bhatia T, Deshpande SN, Nimgaonkar VL, Thelma BK (2004).  Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples.  American Journal of Medical Genetics 131B(1):6-9.

67.  Prasad KM, Chowdari KV, Nimgaonkar VL, Talkowski ME, Lewis DA, Keshavan MS (2005). Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients.  Molecular Psychiatry 10:213-219.

68.  Bhatia T, Sebeeha MR, Shriharsh V, Garg K, Segman RH, Uriel HL, Strous R, Nimgaonkar VL, Bernard L, Deshpande SN (2004). Clinical and familial correlates of tardive dyskinesia in India and Israel. Journal of Postgraduate Medicine 50(3):167-172.

69.  Tiwari AK, Deshpande SN, Rao AR, Bhatia T, Mukit SR, Shriharsh V, Lerer B, Nimgaonkar VL, Thelma BK (2005).  Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: I.  Association of CYP1A2 gene polymorphism.  The Pharmacogenomics Journal 5(1):60-69.

70.  Tiwari AK, Deshpande SN, Rao AR, Bhatia T, Lerer B, Nimgaonkar VL, Thelma BK (2005).  Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: III.  Lack of association of CYP3A4 gene polymorphisms.  Schizophrenia Research 75(1):21-26.

71.  Cordeiro W, Talkowski ME, Chowdari KV, Wood J, Nimgaonkar VL, Vallada H (2005).  Association and linkage analysis of RGS4 polymorhpisms with schizophrenia and bipolar disorders in Brazil. Genes, Brain and Behavior 4(1):45-50.

72.  Mulle JG, Chowdari KV, Nimgaonkar VL, Chakravarti A, et al. (2005).  No evidence for association to the G72/G30 locus in an independent sample of schizophrenia families.  Molecular Psychiatry 10(5):431-433.

73.  Mansour A, Monk TH, Nimgaonkar VL (2005).  Circadian genes and bipolar disorder.  Annals of  Medicine (Trends in Molecular Medicine) 37:196-205.

74.  Mansour HA, Wood J, Chowdari KV, Dayal M, Thase ME, Kupfer DJ, Monk TH, Devlin B, Nimgaonkar VL (2005).  Circadian phase variation in Bipolar I Disorder.  Chronobiology International 22(3):571-584.

75.  Mansour HA, Wood J, Logue T, Chowdari KV, Dayal M, Kupfer DJ, Monk TH, Devlin B, Nimgaonkar VL (2005).  Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia.  Genes, Brain & Behavior in press.

76.  Northup A, Nimgaonkar VL (2004).  Genetics of schizophrenia:  implications for treatment.  Expert Rev Neurother 4(4):89-95.

77.  Deshpande SN, Varma PG, Semwal P, Rao AR, Bhatia T, Nimgaonkar VL, Lerer B, Thelma BK (2005).  Serotonin receptor gene polymorphisms and their association with tardive dyskinesia among schizophrenia patients from North India.  Psychiatric Genetics 15:00-000.

78.  McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Jamra RA, et al. (2005).  Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence for susceptibility loci on chromosomes 6q and 8 q.  American Journal of Human Genetics 77: 582-595.

79.  Klei J, Reitz P, Miller M, Wood J, Maendel S, Gross D, Waldner T, Eaton J, Monk TH, Nimgaonkar VL (In press).  Heritability of morningness-eveningness and self-report sleep measures in a family based sample of 521 Hutterites.  Chronobiology International.

80.  Mansour HA, Talkowski ME, Wood J, Pless L, Bamne M, Chowdari KV, Allen M, Bowden CL, Calabrese J, El-Mallakh RS, Fagiolini A, Faraone SV, Fossey MD, Friedman ES, Gyulai L, Hauser P, Ketter TA, Loftis JM, Marangell LB, Miklowitz DJ, Nierenberg AA, Patel J, Sachs GS, Sklar P, Smoller JW, Thase ME, Frank E, Kupfer DJ, Nimgaonkar VL (2005).  Serotonin gene polymorphisms and bipolar 1 disorder:  focus on the serotonin transporter.  Annals of Medicine; 37, 1-13.

81.  McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, et al (53 authors) (in press).  Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence for susceptibility loci on chromosomes 6q and 8q.  American Journal of Human Genetics.


Selected scienific papers by Dr. Kodavali V Chowdari


1. Ramakrishna W, Chowdari KV , Lagu MD, Gupta VS, Ranjekar PK (1995). DNA fingerprinting to detect genetic variation in rice using hypervariable DNA sequences. Theoretical and Applied Genetics, 90 : 1000-1006.

2. Rajebhosale MD, Chowdari KV , Ramakrishna W, Tamhankar SA, Gupta VS, Gnanamanickam SS, Ranjekar PK (1997). DNA fingerprinting of Indian isolates of Xanthomonas oryzae pv. Oryzae. Theoretical and Applied Genetics, 95 : 103-111.

3. Chowdari KV , Davierwala AP, Gupta VS, Ranjekar PK, Govila OP (1998). Genotype identification and assessment of genetic relationships in pearl millet [pennisetum glacum (L.) R.Br] using microsatellites and RAPDs. Theoretical and Applied Genetics, 97 : 154-162.

4. Chowdari KV , Venkatachalam SR, Davierwala AP, Gupta VS, Ranjekar PK, Govila OP (1998). Hybrid performance and genetic distance as revealed by the (GATA)4 microsatellite and RAPD markers in pearl millet. Theoretical and Applied Genetics, 97 : 163-169.

5. Chowdari KV , Ramakrishna W, Tamhankar SA, Hendre RR, Gupta VS, Sahasrabudhe NA, Ranjekar PK (1998). Identification of minor DNA variations in rice somaclonal variants. Plant Cell Reports, 18 : 55-58.

6. Parasnis AS, Ramakrishna W, Chowdari KV , Gupta VS, Ranjekar PK (1999). A microsatellite (GATA)4 enables early sex identification of papaya seedlings. Theoretical and Applied Genetics, (in press).


 

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