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Director: Greg J. Siegle, Ph.D.

                                                                                                                       Program Coordinator: Marlee Pyzewski

Links & Resources


Helpful and interesting links related to the Program in Cognitive Affective Neuroscience.

Labs & Groups

  • CATS
    The Child Anxiety Treatment Study
    The Mood Disorders Treatment Research Program
  • The Biometrics Research Program
    Devoted to understanding physiological correlates of cognition in individuals with and without psychopathology.
  • Remedy Research Group
    PICAN faculty collaborator, Dr. Dana McMakin's research group website
  • NITO Lab
    PICAN faculty collaborator, Dr. Rebecca Price's research group website
  • CAN Lab
    Pittsburgh Clinical Application of Neuroscience Laboratory - PICAN faculty collaborator, Dr. Rebecca Price
  • DASC
    The Developmental Affective Science Collective 
  • TREND Artist in Residence Series
    The Transdisciplinary Research in Emotion, Neuroscience, and Development (TREND) Artist in Residence Series
    • We are pleased to announce that the University of Pittsburgh School of Medicine's Transdisciplinary Research in Emotion Neuroscience and Development (TREND) Artist in Residence for 2011 will be the local sculptor Richard Claraval. Richard's residency, which will take place September 7-9, will be devoted to exploring the process of sculpting using a newly available technology for assessing brain waves (EEG) while he works. This project has the potential to significantly advance our understanding of what it means to be creative in-the-moment.

      Richard's work can be viewed at

Animations & Pictures

  • Animation showing the location of the amygdala
    Roma Konecky and Greg Siegle made this from an SPGR image acquired on a 1.5T GE scanner using BrainVoyager to align and smooth the image, MRICro to trace the amygdala, AFNI to create the rendering, and WWW Gif Animator to concatenate the frames.
  • Animation showing the mean of 25 control participants' brain activity associated with rating the personal relevance of positive words.
    The animation was made by generating a snapshot of regions significantly different (p<0.001) from the pre-trial baseline at each TR (1.5 seconds) for the 12 second trial (in AFNI), and interpolating between them (in Virtual Dub). As shown in the animation the anterior cingulate reacts early, followed slightly later by BA47, a brain region associated with rumination. Data from Siegle, G.J., Thompson, W., Thase, M.E., Steinhauer, S.R., Carter, C. S., (in press). Increased amygdala and decreased dorso-lateral prefrontal BOLD responses in unipolar depression: Related and independent features. Biological Psychiatry. Animation by Greg Siegle and Lena Gemmer.

Software & Research Projects