INVESTIGATION

Patrick Sullivan, M.D., FRANZCP, University of North Carolina, Chapel Hill, NC

Patrick Sullivan, M.D., FRANZCP, is a Professor of Genetics, Psychiatry, and Epidemiology at UNC and Foreign Adjunct Professor, Karolinska Institutet, in Stockholm, Sweden.

Dr. Sullivan received his BS from the University of Notre Dame in 1981, his MD degree from the University of California , San Francisco in 1988, and completed his psychiatry residency at the University of Pittsburgh .  He received his FRANZCP in Christchurch , New Zealand in 1994.  The over-arching theme of Dr. Sullivan’s research is the attempt to understand the etiology of a number of important complex disorders that represent public health problems.  These disparate disorders have several common features.  They are common, etiologically heterogeneous, and exhibit complex patterns of inheritance.  Their study is made more difficult by the inaccessibility of the brain regions of interest and the absence of compelling animal models.  Dr. Sullivan believes that in order to develop an understanding of these disorders the integration of findings from multiple investigative approaches such as bioinformatics, epidemiology, linkage analysis, and association studies are of utmost importance.  His lab applies these methods to several research areas such as schizophrenia, smoking behavior, chronic fatigue syndrome, pharmacogenetics, autism, and eating disorders.  He has active research collaborations throughout the United States , Holland, Sweden,  Australia, Norway, and Brazil.  Dr. Sullivan has published 153 journal articles, 17 chapters or invited articles, and 2 miscellaneous items.  He has recently developed TAMAL (Technology And Money Are Limiting) web site (in collaboration with Bradley Hemminger and Billy Saemlim) to help identify promising single nucleotide polymorphisms (SNPs) for further genetic investigation.  TAMAL is a platform independent web-based application available free of charge at http://neoref.ils.unc.edu/tamal.  Dr. Sullivan’s lab has also developed SLEP (Sullivan Lab Evidence Project) website (https://slep.unc.edu/evidence/) which  allows users to search the accumulated data to find the evidence in support of the involvement of a particular genomic region with a set of the disorders of central importance in psychiatry – autism, bipolar disorder, major depressive disorder and schizophrenia. Recently, Dr. Sullivan joined The Genetic Association Information Network (GAIN) Collaborative Research Group and will be involved in the investigation of the genetic basis of common diseases through a series of genome wide association studies. For more information on Dr. Sullivan’s work, please visit: http://www.med.unc.edu/~pfsulliv/.

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