Neurophysics Laboratory

 

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Kanagasabi Panchalingam, Ph.D.

Bradler JE, Barrionuevo G, Panchalingam K, McKeag D & Pettegrew JW. Intermediates of phospholipid metabolism elevate in alzheimer's disease have neurophysiological and metabolic actions in hippocampus. Synapse, 9: 7-13, 1991.

Geddes JW, Panchalingam K & Pettegrew JW. Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions. Neurobiological Aging, 18(3): 305-308, 1997.

Klunk WE, Panchalingam K, McClure RJ, Stanley JA & Pettegrew JW. Metabolic alterations in postmortem alzheimer’s disease brain are exaggerated by apo-e4. Neurobiological Aging, 19(6): 511-515, 1998.

Klunk WE, Panchalingam K, Moossy J, McClure RJ & Pettegrew JW. N‑acetyl‑ l ‑aspartate and other amino acid metabolites in alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study. Neurology, 42: 1578‑1585, 1992.

Klunk WE, Xu C, Panchalingam K, McClure RJ & Pettegrew JW. Analysis of magnetic resonance spectroscopic data by the mole percent method: comparison to results expressed in absolute units. Neurobiological Aging, 15(1): 133-140, 1994.

Klunk WE, Xu C, Panchalingam K, McClure RJ & Pettegrew JW. Quantitative 1h and 31p mrs study of postmortem alzheimer's disease brain. Neurobiological Aging, 17: 349-357, 1996.

Levine J, Panchalingam K, McClure RJ, Gershon S & Pettegrew JW. Stability of csf metabolites measured by proton nmr. Journal of Neural Transmission (Budapest), 107(7): 843‑8, 2000.

Levine J, Panchalingam K, Rapoport A, Gershon S, McClure RJ & Pettegrew JW. Increased cerebrospinal fluid glutamine levels in depressed patients. Biological Psychiatry, 47: 586-593, 2000.

McClure RJ, Kanfer JN, Panchalingam K, Klunk WE & Pettegrew JW. Alzheimer's disease: membrane-associated metabolic changes. Annals of the New York Academy of Sciences, 747: 110-24, 1994.

McClure RJ, Kanfer JN, Panchalingam K, Klunk WE & Pettegrew JW. Magnetic resonance spectroscopy and its application to aging and alzheimer's disease. Neuroimaging Clinics of North America, 5 (1): 69-86, 1995.

McClure RJ, Stanley JA, Panchalingam K, Perkins KA & Pettegrew JW. In vivo 31p mrs study of brain molecular effects of nicotine. Society of Neuroscience Abstracts, 28: 502.18, 2002.

Panchalingam K, Sachedina S, Pettegrew JW & Glonek T. Al-ATP as an intracellular carrier of al(III) Ion. International Journal of Biochemistry, 23 (12): 1453-1469, 1991.

Pettegrew JW, Keshavan MS, Panchalingam K, Strychor S, Kaplan DB, Tretta MG & Allen M. Alterations in brain high energy phosphate and membrane phospholipid metabolism in first episode, drug naive schizophrenics: a pilot study of the dorsal prefrontal cortex by in vivo nmr spectroscopy. Archives of General Psychiatry, 48: 563-568, 1991.

Pettegrew JW, Klunk WE, Panchalingam K, Kanfer JN & McClure RJ. Clinical and neurochemical effects of acetyl-l-carnitine in alzheimer’s disease. Neurobiological Aging, 16: 1-4, 1995.

Pettegrew JW, Klunk WE, Panchalingam K, McClure RJ & Stanley JA. Magnetic resonance spectroscopic changes in Alzheimer’s disease. Annals of the New York Academy of Sciences, 826:  282-306, 1997.

Pettegrew JW, Panchalingam K, Klunk WE, McClure RJ & Muenz LR. Alterations of cerebral metabolism in probable alzheimer's disease; a preliminary study. Neurobiological Aging, 15(1): 117-132, 1994.

Pettegrew JW, Panchalingam K, Moossy J, Martinez JA, Rao G & Boller F. Correlation of phosphorus-31 magnetic resonance spectroscopy and morphological findings in alzheimer's disease. Archives of Neurology, 45: 1093-1096, 1988.

Pettegrew JW, Panchalingam K, Withers G, McKeag D & Strychor S. Changes in brain energy and phospholipid metabolism during development and aging in fischer 344 rat, Journal of Neuropathology and Experimental Neurology,  49: 237-249, 1990.

Pettegrew JW, Post JFM, Panchalingam K, Withers G & Woessner DE. 7Li nmr of normal human erythrocytes. Journal of Magnetic Resonance, 71: 504-519, 1987.

Pettegrew JW, Stanley JA, Panchalingam K & McClure RJ. In vivo 31p-1h mrs study of membrane phospholipid metabolism in ad. Society of Neuroscience Abstracts, 28: 228.2, 2002.

Pettegrew JW, Withers G, Panchalingam K & Post JFM. Considerations for brain ph assessment by 31p nmr, Magnetic Resonance Imaging,  6: 135-142, 1988.

Pettegrew JW, Withers G, Panchalingam K & Post JFM. 31P nuclear magnetic resonance (nmr) spectroscopy of brain in aging and alzheimer's disease. Journal of Neural Transmission Supplement, 24: 261-268, 1987.

Pettegrew JW, Panchalingam K, Levine J, McClure RJ, Gershon S & Yao JK. Chronic myo‑inositol increases rat brain phosphatidylethanolamine plasmalogen. Biological Psychiatry, 49(5): 444‑53, 2001.

Pettegrew JW, Panchalingam K, McClure RJ, Gershon S, Muenz LR & Levine J. Effects of chronic lithium administration on rat brain phosphatidylinositol cycle constituents, membrane phospholipids and amino acids. Bipolar Disorders, 3(4): 189‑201, 2001.

Pettegrew JW, Panchalingam K, Hamilton RL & McClure RJ. Brain membrane phospholipid alterations in Alzheimer's disease. Neurochemical Research, 26(7): 771-82, 2001.

Pettegrew JW, Panchalingam K, McClure RJ & Levine J. Brain metabolic effects of acute nicotine. Neurochemical Research, 26(2): 181-5, 2001.

Stanley JA, Kipp H, Greisenegger E, MacMaster FP, Panchalingam K, Pettegrew JW, Keshavan MS, Bukstein OG.  Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study.  Psychiatry Res. 2006 Dec 1;148(2-3):217-21. Epub 2006 Nov 7

Sweet RA. Panchalingam K, Pettegrew JW, McClure RJ, Hamilton RL, Lopez OL, Kaufer DI, DeKosky ST & Klunk WE. Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology. Neurobiology of Aging, 23(4): 547_53, 2002.

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