Neurophysics Laboratory

 

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Jay W. Pettegrew, M.D.

Geddes JW, Panchalingam K, and PETTEGREW JW. Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions. Neurobiological Aging, 18(3): 305-308, 1997.

Keshavan MS, Schooler NR, Sweeney JA, Haas, GL, and PETTEGREW JW. Research and treatment strategies in first episode psychoses: the pittsburgh experience. British Journal of Psychiatry, 172(33): 60-65, 1998.

Keshavan MS, Stanley JA, and PETTEGREW JW. Magnetic resonance spectroscopy in schizophrenia: methodological issues and findings, part II. Biological Psychiatry, 48: 369-380, 2000.

Klunk WE, Panchalingam K, McClure RJ, Stanley JA, and PETTEGREW JW. Metabolic alterations in post-mortem alzheimer’s disease brain are exaggerated by apo-e4. Neurobiological Aging, 19(6): 511-515, 1998.

Klunk WE, Xu C-J, McClure RJ, and PETTEGREW JW. Aggregation of b-amyloid peptide is promoted by membrane phospholipid metabolites elevated in alzheimer’s disease. Journal of Neurochemistry, 69: 266-272, 1997.

Klunk WE, Xu CJ, Panchalingam K, McClure RJ and PETTEGREW JW. Quantitative 1h and 31p mrs of pca extracts of postmortem alzheimer’s disease brain. Neurobiological Aging, 17: 349-357, 1996.

Mandal PK, PETTEGREW JW, McKeag DW, Mandal R.  Alzheimer's disease: halothane induces Abeta peptide to oligomeric form--solution NMR studies.  Neurochem Res. 2006 Jul;31(7):883-90. Epub 2006 Jun 29

Mandal PK, PETTEGREW JW, Masliah E, Hamilton RL, Mandal R.  Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochem Res. 2006 Sep;31(9):1153-62. Epub 2006 Sep 1

Mandal PK, McClure RJ, and PETTEGREW JW. Interactions of aβ(1-40) with glycerophosphocholine and intact erythrocyte membranes: fluorescence and circular dichroism studies. Neurochemical Research, 29: 2261-2267, 2004.

 Mandal PK and PETTEGREW JW. Alzheimer’s disease: soluble oligomeric aβ(1-40) peptide in membrane mimic environment from solution nmr and cd studies” Neurochemical Research, 29: 2255-2260, 2004.

Mason RP, Trumbore MW, and PETTEGREW JW. Molecular membrane interactions of a phospholipid metabolite. implications for alzheimer’s disease pathophysiology. Annals of the New York Academy of Sciences, 96: 368-373, 1996.

Mason RM, Trumbore M. and PETTEGREW JW. Membrane interactions of a phosphomonoester elevated early in alzheimer’s disease. Neurobiological Aging, 16: 531-539, 1995.

McClure RJ, Keshavan MS, and PETTEGREW JW. Chemical and physiologic brain imaging in schizophrenia. Psychiatric Clinics of North America, 21(3): 93-122, 1998.

PETTEGREW JW, Keshavan, MS, Stanley JA, McClure RJ, Johnson CR and Panchalingam K. Magnetic resonance spectroscopy in the assessment of phospholipid metabolism in schizophrenia and other psychiatric disorders. In: Phospholipid Spectrum Disorder in Psychiatry (eds. Peet M, Glen I and Horrobin DF), Marious-Carnford, UK, pp. 239-255, 2003.

 PETTEGREW JW, Klunk WE, Panchalingam K, Kanfer JN and McClure RJ. Clinical and neurochemical effects of acetyl-l-carnitine in alzheimer's disease. Neurobiological Aging, 16: 1-4, 1995.

PETTEGREW JW, Klunk WE, Panchalingam K, McClure RJ and Stanley JA. Molecular insights into neurodevelopmental and neurodegenerative diseases. Brain Research Bulletin, 53: 455-469, 2000.

PETTEGREW JW, Levine J, Gershon S, Stanley JA, Servan, Schreiber D, Panchalingam K and McClure RJ. 31P-mrs study of acetyl-l-carnitine treatment in geriatric depression: preliminary results. Bipolar Disorders, 4: 61-66, 2002.

PETTEGREW JW, Levine J, and McClure RJ. Acetyl-l-carnitine physical, chemical, metabolic and therapeutic properties: relevance for its mode of action in alzheimer’s disease and geriatric depression. Molecular Psychiatry, 5: 616-632, 2000.

PETTEGREW JW, McClure RJ, Keshavan MS, Minshew NJ, Panchalingam K, and Klunk WE. 31P magnetic resonance spectroscopy studies of developing brain. In:  Neurodevelopment & Adult Psychopathology, Keshavan MS and Murray RM (eds.), Cambridge University Press, 6: 71-92, 1997.

PETTEGREW JW, Panchalingam K, Hamilton RL and McClure RJ. Brain membrane phospholipid alterations in alzheimer's disease. Neurochemical Research, 26: 771-782, 2001.

PETTEGREW JW, Panchalingam K, Levine J, McClure RJ, Gershon S, and Yao J. K. Chronic myo-inositol increases rat brain phosphatidylethanolamine plasmalogen. Biological Psychiatry, 49: 444-453, 2001.

PETTEGREW JW, Panchalingam K, McClure RJ and Levine J. Brain metabolic effects of acute nicotine. Neurochemical Research, 26: 181-185, 2001.

Stanley JA, Kipp H, Greisenegger E, MacMaster FP, Panchalingam K, PETTEGREW JW, Keshavan MS, Bukstein OG.  Regionally specific alterations in membrane phospholipids in children with ADHD: An in vivo 31P spectroscopy study.  Psychiatry Res. 2006 Dec 1;148(2-3):217-21. Epub 2006 Nov 7

Stanley JA and PETTEGREW JW. Postprocessing method to segregate and quantify the broad components under-lying the phosphodiester spectral region of in vivo 31p brain spectra. Magnetic Resonance in Medicine, 45: 390-396, 2001.

Stanley JA and PETTEGREW JW. Post-processing method to segregate and quantify the broad components underlying the phosphodiester spectral region of in vivo 31p brain spectra. Magnetic Resonance in Medicine, 45: 390-396, 2001.

Stanley JA, PETTEGREW JW, and Keshavan MS. Magnetic resonance spectroscopy in schizophrenia: methodological issues and findings, part I. Biological Psychiatry, 48: 357-368, 2000.

Stanley JA, PETTEGREW JW, Panchalingam K, McClure RJ, Harenski K, Montrose DM and Keshavan MS. Focal and global alterations of membrane phospholipid metabolism in offspring subjects of schizophrenia parents: an in vivo 31p mrs study. Schizophrenia Research, 49: 195, 2001.

Xu CJ, Kanfer JN, Klunk WE, Xiong Q, McClure RJ and PETTEGREW JW. Effect of phosphomonoesters, phosphodiesters, and phosphocreatine on glutamate uptake by synaptic vesicles. Molecular Neurochemical Neuropathology, 32:  89-99, 1997.

 Xu CJ, Klunk WE, Kanfer JN, Xiong Q, Miller G & PETTEGREW JW. Phosphocreatine-dependent glutamate uptake by synaptic vesicles: a comparison with atp-dependent glutamate uptake. Journal of Biological Chemistry, 271: 13435-13440, June 1996.

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