Ganguli M, Dodge HH, Chen P, Belle S, DeKosky ST. Ten-year incidence of dementia in a
rural elderly US community population: the MoVIES Project. Neurology, 54: 1109-1116, 2000.
OBJECTIVE: To determine incidence rates by age, sex, and education of
overall dementia and probable/ possible AD in a largely rural community.
METHODS: Ten-year prospective study of a randomly selected community
sample aged 65+; biennial cognitive screening followed by standardized
clinical evaluation. Incidence rates were estimated for overall dementia
(Diagnostic and Statistical Manual of Mental Disorders, 3rd ed., revised,
criteria and Clinical Dementia Rating [CDR]) and for probable/possible AD
(National Institute of Neurological and Communicative Disorders and
Stroke-Alzheimer's Disease and Related Disorders Association criteria).
RESULTS: The cohort consisted of 1,298 individuals free of dementia at
study entry. Among these, 199 incident (new) cases of overall (all-cause)
dementia with CDR stage > or = 0.5, including 110 with CDR > or = 1, were
detected during follow-up. Among the incident cases, 153 (76.9%) had probable/
possible AD. Age-specific incidence rates are reported for all dementia and
for probable/possible AD, by sex and CDR stage. Among all-cause dementias with
CDR = 0.5, controlling for age and education, men had a higher incidence rate
than women. In the same group, those with less than high school education had
significantly higher incidence rates than those with more education. Rates did
not vary significantly by sex or education for probable/possible AD or for
dementia with CDR > or = 1.
CONCLUSIONS: Incidence rates of all
dementias and of AD increased with age; men and those with lesser education
had higher rates of possible/incipient dementia (CDR = 0.5) in this community.
Potential explanations for these sex and education effects are discussed.