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Mild Cognitive Impairment: A Prospective Community Study. aka Mon-Yough Health and Aging Team is supported in part by the NIA* under research grant #AG023651 (Principal Investigator: Mary Ganguli).
The MYHAT project will seek to describe the distribution of Cognitive Impairment, No Dementia (CIND) and Mild Cognitive Impairment (MCI) and related entities, their associated features, their outcomes over time, and the predictors of these outcomes. An age-stratified random community sample of approximately 2,100 will be recruited and screened using cognitive, functional, and other health-related measures, to identify the non-demented who are cognitively impaired. Among them, we will identify subgroups meeting operational criteria for MCI of amnestic and other varieties. Participants will be further classified according to multiple, potentially overlapping, schema which are in current use by different groups. Subgroups will be also characterized with regard to demographic, clinical, and biological variables which may predict outcomes and/or have diagnostic significance. Annual follow-up assessments will track changes in cognitive and functional ability and identify transitions to clinical states including Alzheimer's disease and other dementing disorders. Analysis of these prospectively gathered data will allow subgroups to be defined according to outcome, and thus permit the empirical refinement of clinical and research criteria for various forms of mild cognitive impairment.
We acknowledge support from the National Institute on Aging (NIA).
Last Modified 07/28/11