How the newest antidepressants work in children and adolescents
Can you contribute to understanding?
Children and adolescents between the ages of 7 and 17 years and 11 months who
are starting treatment or changing to treatment with Luvox
(fluvoxamine) , Zoloft (sertraline), or Paxil (paroxetine) will be eligible
for the study.
Course of Treatment
Children or adolescents eligible for the study will drink a can of caffeinated cola and
a dose of cough syrup. Their urine will then be collected to determine the activity of
certain liver enzymes. Following this patients will receive a single dose of medication
and have blood levels measured. They will then stay on the same dose of medication for 2
weeks and return to the clinic for repeat blood levels. Patients, parents, research
clinicians will be aware of which medication the patient is receiving. Treatment provided
through the study is free of charge.
Qualifications of Investigators
David Axelson, M.D., Research Fellow
Boris Birmaher, M.D., Associate Professor of Psychiatry
James Perel, Ph.D., Professor of Psychiatry and Pharmacology
For more information or referral please contact Sue Wassick, RN, tel: 383-9837.
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