autism research page banner

Investigators Current Studies Perspectives Program intervention for adults ASSET-Adolescent Social-emotional Skills Enhancement Training ADDIRC and Emotion Dysregulation Completed Studies Infant Siblings of ASD Children Categorization in Children & Adults With Autism Emotion Processing Imaging/fMRI   Autism Treatment Network Autism Task Force



Dr. Carla Mazefsky, PhD, University of Pittsburgh


Autism and Developmental Disabilities Inpatient Research Collaborative (ADDIRC)


The Autism and Developmental Disabilties Inpatient Research Collaborative (ADDIRC), founded in 2011, is a collaboration of specialized child psychiatry hospital units, including Western Psychiatric Institute and Clinic's John Merck Inpatient Program that serve children and adolescents with autism and developmental disorders. The primary goal of the ADDIRC is to develop a comprehensive registry of clinical and biological data on severely affected children and adolescents with autism called the Autism Inpatient Collection (AIC).  The researchers plan to look at the dimentsions of expressive language abiltiy, emotional regulation, psychiatric co-morbidity, aggression, self-injurious behavior and intelligence, and to examine the relationships among these critical factors.  Under Dr. Mazefsky's direction, the Pittsburgh site is leading an investigation of the association between emotion dysregulation and psychophysiological biomarkers.  Eligibility for enrollment into the study is based on admission into one of the six inpatient units that makes up the AIC.


For more information about the sites and recent publications and presentations from ADDIRC, see


For information and questions pertaining to the Pittsburgh site/Western Psychiatric Institute and Clinic (WPIC), contact Jessica Vezzoli at or 412-334-1356


Change-sensitive Measurement of Emotion Dysregulation in ASD


Problems with emotional control and emotional disress in atuism spectrum disorders (ASD) are common and have a significant negative impact on daily life.  Treatment options for these problems are limited, in part becasuse we lack validated measures of emotion dysregulation for ASD.  Most measures of emotional concerns use language that does not apply to individuals with ASD who are non-verbal or minimally verbal (e.g., "complains about, " "worries about") and they fail to cover the full range of presenting symptoms.  The overall objective of this project is to develop and validate the Emotion Dysregulation Inventory (EDI), a new, sensitive outcome measure suitable for use across the spectrum of ASD severity and verbal abiltiy. Although the primary goal is related to measure development, this study will also produce the largest existing data set of symptoms of emtion dysregulation in ASD, which will provide an opportunity to better understand emotion dysregulation in ASD.  Improved understanding of emotion dysregulation in ASD will clarify treatment needs, allowing for more refined clinical trials.  In addition, better measurement of emotion profiles may enhance the capabilities of genetic and neuroimaging research by capturing variabiltiy within ASD.  Finally, because the EDI is a dimensional measure of emtional domains, that are also of interest in non-ASD fields of developmental psychopathology, there will be a new opportunity for studies across populations.


Data is being collected in collaboration with the Autism and Developmental Disabilities Inpatient Research Collaborative (ADDIRC) and Interactive Autism Network (IAN).


For more information, contact Carla Mazefsky at


Webster Hall, Suite 300, 3811 O’Hara Street, Pittsburgh, PA 15213 • Toll Free 1-866-647-3436 • Phone 412-246-5485 • Fax 412-246-5470

All Inquiries including Dr. Minshew:
2006 CeFAR at the University of Pittsburgh