How does the brain use emotional information in depression?

A Research Study

This study examines brain activity underlying depression and may be useful in creating new treatments for depression. Participants will be asked to pay attention to emotional words while a video camera observes their eye. Participants may also be invited to have an MRI. The study is not an intervention and does not require medications.

You may be eligible to participate if you have unipolar depression and are not taking antidepressants or have never been depressed.

The study involves up to 3 visits including:

•   A clinical interview (approximately 1 hr)

•   Pupil dilation assessment (3 ˝ hours)

•   Either a 2nd pupil dilation assessment or an MRI (2-3 hours)

The fine print:
Participants will be paid up to $120 upon the study’s completion and will be shown how their brain reacts to emotional information. Participants who elect to have an MRI will receive a picture of their brain.

•Individuals who have normal corrected vision and who are currently depressed, have no recent history of substance abuse or dependence (past 3 months), have no psychotic symptoms, have never had a manic episode, and who are currently unmedicated may participate. Individuals who are not currently depressed, have no history of mood disorder, who do not have a family history of depression may also participate as control participants. Individuals who have metal implants in their body, or who have a heart condition or are pregnant may not participate in the fMRI component of the experiment, but may participate in the other components.

For further information contact Lisa at the
Program in Cognitive Affective Neuroscience
ph:  412-624-3242     Fax: 412-624-0223
e-mail: pican@upmc.edu

This research is sponsored by NARSAD and the National Institute of Mental Health