We have received funding from the National Institute of Mental Health (NIMH) to study depression in adolescents who do not respond to common treatments for depression.  The study aims to establish useful clinical guidelines for the care and management of adolescent depression.

We are located in six locations throughout the United States:

• Brown University, Providence, Rhode Island

• Kaiser Permanente Center for Health Research, Portland, Oregon

• University of California at Los Angeles, Los Angeles, California

• University of Texas Medical Branch, Galveston, Texas

• University of Texas Southwestern Medical Center, Dallas, Texas

• Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania (Coordinating Site)

Study Participation

We are looking for adolescents who are:

• Between the ages of 12 years 0 months to 18 years 11 months.

• Currently in treatment for depression.

• Taking Prozac, Celexa, Lexapro, Zoloft, Luvox, or Paxil (Providence, RI and Portland, OR sites only).

•  Still feeling depressed.

If this describes you, your child, or someone that you know, that person could be eligible to participate in research studying depression in adolescents who do not respond to common treatments.

What We Offer

Individuals asked to participate in the study after an initial evaluation will receive the following (at no cost):

• A complete psychiatric evaluation.

• All study medication.

• Monitoring of psychiatric and physical symptoms throughout the study.

• Compensation for time and parking.

Individuals asked to participate in the study after an initial evaluation will receive the following (at no cost):

• A complete psychiatric evaluation.

• All study medication.

• Monitoring of psychiatric and physical symptoms throughout the study.

• Compensation for time and parking.

Participants will be randomly assigned to take one of three medications (Prozac, Celexa, or Effexor XR), either alone or in combination with cognitive behavior therapy. Participants also will be closely monitored for 24 weeks and receive follow-up psychiatric evaluations for one year.  If at any time during the study there is little or no improvement or symptoms worsen, the participant may be withdrawn from the study and offered other treatment options
 

If you are interested in learning more about the study, please contact the project coordinator in your area or call toll-free at 1-866-666-2538. All calls are confidential.

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