Mary L. Phillips, MD
Professor in Psychiatry,

Director of Clinical and Translational Affective Neuroscience Program, Department of Psychiatry,

Western Psychiatric Institute and Clinic,

University of Pittsburgh School of Medicine,

Loeffler Building,

121 Meyran Avenue                                                 ,

Pittsburgh. PA 15213.

Tel: (+1) 412-383-5177 Fax: (+1) 412-383-8336

E-Mail: fmristudies@upmc.edu

 


Dr. Mary Phillips trained in Medicine at the University of Cambridge, UK and in Psychiatry at the Maudsley Hospital, London and Institute of Psychiatry, UK.

She received a research training fellowship from the Medical Research Council (UK) to examine visual scan paths in schizophrenia. She subsequently developed a research interest in the application of functional neuroimaging techniques to the examination of the neural basis of emotion processing in healthy and psychiatric populations. She has, in particular, focused on the identification of neural correlates that underlie the symptoms of specific abnormalities in emotion processing in individuals with mood disorders.

She became Professor of Neuroscience and Emotion and Head of Section of Neuroscience and Emotion within the Department of Psychiatry, Division of Psychological Medicine, Institute of Psychiatry, King’s College, London, UK in 2003.

In October, 2004, she joined the Department of Psychiatry at the University of Pittsburgh as part-time Visiting Professor and Director of the Functional Neuroimaging Program, moving to become a Professor of Psychiatry in April, 2006.

In 2005, Dr. Phillips became a member of The American College of Neuropsychopharmacology, and in 2006, was awarded the Nellie Blumenthal Investigator by the National Alliance for Research in Schizophrenia and Depression.

Since 2006, Dr. Phillips has been Co-Director of the Brain Imaging Research Center within Carnegie Mellon University and the University of Pittsburgh.

In January, 2008, Dr. Phillips moved her UK research base to Cardiff University, UK, to take up the position of Professor in Clinical Affective Neuroscience in the Department of Psychological Medicine part-time.

Dr Phillips now heads teams of dedicated researchers in the US and UK at both institutions.

Dr Phillips has received research funding awards from the Medical Research Council (UK) and the Wellcome Trust in the UK, and, more recently from NIMH in the US.

Dr. Phillips is mentor to nearly 20 junior investigators in both institutions, and has authored or co-authored over 130 publications.
 


Collaborations

 

The overarching aim of Dr. Phillips research has been to elucidate neural systems underlying vulnerability to mood and anxiety disorders.

 

The following are a list of current collaborations and funding .

 

Current Research with Dr. Phillips as PI:

 

  1. Toward the Identification of Biomarkers of Bipolar Disorders. with Drs Frank, Kupfer ( NIMH.)

  2. Examination of the Functional Neuroanatomical Basis of Mood Dysregulation in Bipolar Disorder. with Drs. Siegle,Kupfer,Thase (institute funded).

Assistant Faculty Awards with Dr. Phillips as Co-Investigator:

  1. Neural Correlates of Emotion Regulation in Adolescents at Risk for Bipolar Disorder. Primary Investigator: Ladouceur, C. Co-Investigators: Phillips, M., Birmaher B. Funding Source: NARSAD

  2. Toward the Identification of Neurodevelopmental Risk Markers of Bipolar Disorder. Primary Investigator: Ladouceur, C. Phillips, M. as a mentor. Funding Source: NARSAD

  3. Examining Neural Substrates of Obsessive Compulsive Disorder Symptom Dimensions in Pediatric Obsessive Compulsive Disorder. Primary Investigator: Gilbert, A. Co-Investigators: Phillips, M., Birmaher, B. Funding Source: NIMH.

  4. Neural Circuitry Underlying Early-Onset Suicide Attempt. Primary Investigator: Pan, L. Co-Investigators: Phillips, M., Cantab, Brent, D. Funding Source: American Foundation for Suicide Prevention and the Klingenstein Third Generation Foundation

  5. Identifying neural markers of Obsessive Compulsive Disorder in Pediatric and at Risk Populations: A First Stage fMRI study. Primary Investigator: Akkal, D. Co-Investigators: Phillips, M., Gilbert, A. Funding Source: NARSAD

  6. Neural systems underlying urge incontinence in older women: with Dr. Tadic, Department of Medicine (K12 award to Tadic; NIMH)

  7. Neuropsychological Functioning in Depressed Adolescents. Primary Investigator: Maalouf, F. Co-Investigators: Phillips, M., Brent, D. Funding Source: American Academy of child and Adolescent Psychiatry.

  8. Development, Positive Affect and Adolescent Depression. Primary Investigator: Forbes, E. Consultant: Phillips, M. Funding Source: NIMH.

 

Post Doctoral Research with Dr. Phillips as Mentor/Co-Investigator:

 

  1. Abnormalities in Emotion Regulatory Neural Systems in Pediatric Bipolar Disorder. Primary Investigator: Brent, D. Co-Investigators: Farchione, T, Axelson, D., Birmaher. Funding Source: NIMH

  2. Processing Facial Affect in Bipolar Disorder: A Magnetoencephalography Study. Primary Investigator: Hassel, S. Co-Investigators: Phillips, M, Bagic, A. Funding Source: NARSAD

  3. Identifying neural markers of Obsessive Compulsive Disorder in Pediatric and at Risk Populations: A First Stage fMRI study. Primary Investigator: Akkal, D. Co-Investigators: Phillips, M., Gilbert, A. Funding Source: NARSAD

  4. The Interface of Emotion and Self-Image: Visual Self Recognition Across Development in Child and Adolescent Bipolar Disorder. Primary Investigator: Keener, M. Co-Investigators: Phillips, M.,Dahl, R., Silk, J., Goldstein, T.Funding Source: APA-Janssen (not yet active)

  5. Examination of Social Cognitive Processes in Bipolar Disorder using Emotion Processing, Self Perceptual and Moral Decision-Making Tasks. Primary Investigator: Keener, M. Co-Investigators:  Phillips, M., Dahl., R. Funding Source: Institute Funded.

 

External research collaborations:

 

  1. Examining the neural basis of OCD symptom dimensions: with Drs. Mataix-Cols and Lawrence, Department of Psychiatry, Institute of Psychiatry, King’s College, University of London, UK (Wellcome Trust, P.I. Phillips – funding completed but data analyses continue)

  2. The neural basis of reward processing in healthy, depressed and suicide attempters: with Drs. F. Jollant and N. Lawrence, Institute of Psychiatry, London, UK and University of Montpellier, France. (AFSP = Amercian Foundaiton for prevention of suicide to Jollant)

  3. The neural basis of treatment response in MDD: with Drs. Surguladze and Keedwell, Institute of Psychiatry, King’s College, University of London, UK.

  4. Examining the role of dopaminergic and serotonergic candidate genes in modulating behavioral and neural responses during emotion processing and cognitive control: with Dr. S. Surguladze, Institute of Psychiatry, King’s College, University of London, UK.

  5. Multimodal neuroimaging in OCD: a study of anterior cingulate function: with Drs. C. Pantelis and M. Yucel, (NHMRC, Australia., award to Yucel)

  6. Sensitization to alcohol withdrawal: consequences and mechanisms: with Dr. D. Stephens, University of Sussex, UK. (MRC, UK)

  7. Examination of the role of serotonergic antidepressant medication upon neural responses to emotional stimulation: toward understanding the neural mechanisms of serotonergic antidepressant response. Drs. G. Bussato and J. Almeida, University Department of Psychiatry, Sao Paulo, Brazil. (CAPES Foundation, Brazil)

  8. Neurocognitive deficits in adult bipolar disorder and unipolar depression: with Drs. Clarke and Sahakian, Department of Psychiatry, University of Cambridge, UK (Department of Psychiatry translational neuroscience developmental funds – to M.L. Phillips)

  9. Toward identification of biomarker of bipolar spectrum disorder in depressed patients presenting to secondary care: with Drs. Craddock, Owen, Smith, Department of Psychological Medicine, University of Cardiff, UK (Pending, NIHR)
     

 

PUBLICATIONS


Refereed articles


1. Phillips, M.L., Foster, D.H., Honan, W.P., Edgar, G.K. and Heron, J.R. (1994). Optic Neuritis: Differential losses of luminance and chromatic function near a scotoma. Brain, 117, 767-773.
2. Phillips, M.L., Woodruff, P.W.R. and David, A.S. (1996). Stroop interference and facilitation in the cerebral hemispheres in schizophrenia. Schizophrenia Research, 20, 57-68.
3. Phillips, M.L. , Howard, R. and David, A.S. (1996). "Mirror, Mirror on the Wall, Who...?":
Towards a model of visual self-recognition. Cognitive Neuropsychiatry, 1, 153-164.
4. Phillips, M.L. and David, A.S. (1997). Visual scan paths are abnormal in deluded
schizophrenics. Neuropsychologia, 35, 1, 99-105.
5. Woodruff, P.W.R., Phillips, M.L., Rushe, T., Wright, I.C., Murray, R.M., and David, A.S. (1997). Corpus callosum size and inter-hemispheric function in schizophrenia. Schizophrenia Research, 23, 189-196.
6. Phillips, M.L. and David, A.S. (1997). Viewing strategies for simple and chimeric faces: an investigation of perceptual bias in normals and schizophrenic patients using visual scan paths. Brain and Cognition, 35, 225-238.
7. Phillips, M.L. and David, A.S. (1997). A cognitive neuropsychiatric approach to the study of delusions in late-onset schizophrenia. International Journal of Geriatric Psychiatry, 12, 892-901.
8. Phillips, M.L., Young, A.W., Senior, C., Brammer, M., Andrew, C., Calder, A.J., Bullmore, E.T., Perrett D.I, Rowland, D., Williams, S.C.R., Gray, J.A., and David, A.S. (1997). A specific neural substrate for perception of facial expressions of disgust. Nature, 389, 495-498.
9. Phillips, M.L. and David, A.S. (1998). Abnormal visual scan paths: a psychophysiological marker of delusions in schizophrenia. Schizophrenia Research, 29, 235-245.
10. Phillips, M.L., Bullmore, E.T., Howard, R., Woodruff, P.W.R., Wright, I.C., Williams, S.C.R., Simmons, A., Andrew, C., Brammer, M. and David, A.S. (1998). Investigation of facial recognition memory and happy and sad facial expression perception: an fMRI study. Psychiatry Research: Neuroimaging, 83,127-138.
11. Phillips, ML, Young, AW, Scott, SK, Calder, AJ, Andrew, C, Giampietro, V, Williams, SCR, Bullmore, ET, Brammer, M, Gray, JA. (1998). Neural responses to facial and vocal expressions of fear and disgust. Proceedings of the Royal Society: Biological Sciences, B, 265, 1809-1817.
12. Senior, C. Phillips, ML. Barnes, J. & David, A.S. (1999). An Investigation into the Perception of Dominance from Schematic faces: A study using the World Wide Web. Behaviour Research Methods, Instruments & Computers. 31, 341-346.
13. Senior, C., Barnes, J., Jenkins, R., Landau, S., Phillips, M.L., David, A.S. (1999). Attribution of social dominance and maleness to schematic faces. Social behaviour and personality, 27,4, 331-338.
14. Phillips, M.L., Williams, L., Senior, C., Bullmore, E.T., Brammer, M.J., Andrew, C., Williams, S.C.R. and David, A.S. (1999). A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics. Psychiatry Research: Neuroimaging, 92, 11-31.
15. Freeman, D., Garety, P.A. and Phillips, M.L. (2000). An examination of hypervigilance for external threat in individuals with generalized anxiety disorder and individuals with persecutory delusions using visual scan paths. Quarterly Journal of Experimental Psychology, 53A, 549-567.
16. Phillips, M.L., Senior, C. and David, A.S. (2000). Perception of threat in schizophrenics with persecutory delusions: an investigation using visual scan paths. Psychological Medicine, 30, 157-167.
17. Critchley HD, Daly EM, Phillips M, Brammer M, Bullmore E, Williams SC, Van Amelsvoort T., Robertson D, David A, Murphy DGM. (2000). Explicit and implicit neural mechanisms for processing of social information from facial expressions: A functional Magnetic Resonance Imaging study. Human Brain Mapping, 9, 93-105.
18. Lambert, M.V., Senior, C., Phillips, M.L. and David, A.S. (2000). Depersonalization in Cyberspace. The Journal of Nervous and Mental Disease,188, 764-771.
19. Lambert, M., Senior, C., Fewtrell, D., Phillips, M.L., David, A.S. (2001). Primary and secondary depersonalisation: a psychometric study. Journal of Affective Disorders, 63, 249-256.
20. Phillips, ML, Marks, IM, Senior, C., Lythgoe, D., O’Dwyer, A-M., Meehan, O., Williams, S.C.R., Brammer, M.J., Bullmore, E.T., and McGuire, P.K. A differential neural response in obsessive-compulsive patients with washing compared with checking symptoms to disgust. Psychological Medicine, 2000, 30, 1037-1050.
21. Kircher, T., Senior, C., Phillips, M.L., Benson, P., Bullmore, E., Rabe-Hesketh, S., Brammer, M., Simmons, A., Bartles, M., David, A.S. (2000). Recognizing one’s own face. Cognition, 78, 1-15.
22. Kircher, T.T.J, Senior, C., Phillips, M.L., Benson, P.J., Bullmore, E.T., Brammer, M., Simmons, A., Williams, S.C.R., Bartels, M. and David, A.S. (2000). Towards a functional neuroanatomy of self processing: effects of faces and words. Cognitive Brain Research,10, 133-144.
23. Critchley, H.D., Daly, E.M., Bullmore, E.T., Williams, S.C.R., Van Amelsvoort, T., Robertson, D.M., Rowe, A., Phillips, M., McAlonan, G., Howlin, P., Murphy, D.G.M. (2000). The functional neuroanatomy of social behaviour: Changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain, 123, 22-3-2212.
24. Phillips, M.L., Medford, N., Young, A.W., Williams, L., Williams, S.C.R., Bullmore, E.T., Gray, J.A., Brammer, M.J. (2001). Time courses of left and right amygdalar responses to fearful facial expressions. Human Brain Mapping, 12, 193-202.
25. Stanton, B.R., David, A.S., Cleare, A.J., Sierra, M., Lambert, Phillips, M.L., Porter, R.J., Gallagher, P. and Young, A.H. (2001). Basal activity of the hypothalamic-pituitary-adrenal axis in patients with Depersonalisation Disorder. Psychiatry Research, 104, 85-89.
26. Phillips, M.L., Medford, N., Senior, C., Bullmore, E.T., Brammer, M.J., Andrew, C., Sierra, M., Williams, S.C.R., David. A.S. (2001). Depersonalization Disorder: thinking without feeling. Psychiatry Research: Neuroimaging, 108, 145-160.
27. Williams, L.M., Phillips, M., Brammer, M.J., Skerrett, D., Lagopoulos, J., Rennie, C., Bahramali, H., Olivieri, G., David, A.S., Peduto, A., Gordon, E. (2001). Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. Neuroimage, 14, 1070-1079.
28. Jarrett, C., Phillips, M., Parker, A., Senior, C. (2001).Implicit Motion Perception In Schizotypy And Schizophrenia: A Representational Momentum Study. Cognitive Neuropsychiatry, 7, 1-14.
29. Lambert, M.V., Senior, C., Phillips, M.L., Sierra, M., Hunter, E., David, A.S. (2001). Visual imagery and depersonalisation. Psychopathology, 34, 259-264.
30. Sierra M, Phillips M, Lambert MV, Senior C, Krystal J, David SA (2001). Lamotrigine in the treatment of depersonalization disorder. Journal of Clinical Psychiatry, 62, 826-827.
31. Sierra M, Lopera F, Lambert MV, Phillips ML, David A. (2002). Separating
Depersonalization and Derealization: The relevance of the Lesion Method. Journal of Neurosurgery, Neurology and Psychiatry, 72, 530-532.
32. Lambert MV, Sierra M, Phillips ML, David AS. (2002).The spectrum of organic depersonalization: A review of the literature plus four new cases. Journal of Neuropsychiatry
and Clin neuroscience, 14, 141-154.
33. Sierra M, Senior C, Dalton J, McDonough M, Bond A, Phillips ML, O'Dwyer AM, David AS. (2002). Autonomic Response in Depersonalisation Disorder. Arch. Gen. Psych, 59, 833-838.
34. Abel, K.M., Allin, M.P.G., Kucharska-Pietura, K., Andrew, C., Bullmore, E.T., Williams, S., Phillips, M.L. (2003). Ketamine and fMRI BOLD signal: distinguishing between effects mediated by change in blood flow versus change in cognitive state. Human Brain Mapping, 18, 135-145.
35. Lange, K., Williams, L.M., Young, A.W., Bullmore, E.T., Williams, S.C.R., Brammer, M.J., Gray, J.A., Phillips, M.L. (2003). Task instructions modulate neural responses to fearful facial expressions. Biological Psychiatry, 53, 226-232.
36. Phillips, M.L., Gregory, L.J., Ng, V., Andrew, C., Brammer, M., Bullmore, E.T, Hobson. A., Thompson, D.G, Williams, S.C.R., Aziz, Q. (2003). The effect of negative emotional context on neural responses to oesophageal stimulation. Brain, 126, 669-684.
37. Mataix-Cols, D., Cullen, S., Lange, K., Zelaya, F., Andrew, C., Amaro, E., Brammer, M.J., Williams, S.C.R., Speckens, A., Phillips, M.L. (2003). Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers. Biological Psychiatry, 53, 482-493.
38. Sierra, M., Phillips, M.L., Krystal, J., David, A.S. (2003). A placebo-controlled, crossover trial of lamotrigine in depersonalisation disorder. Journal of Psychopharmacology, 17,103-105.
39. Kucharska-Pietura, K., Phillips, M.L., David, A.S. (2003). Perception of emotions from faces and voices following unilateral brain damage. Neuropsychologia, 41,1082-1090.
40. Surguladze, S.A., Brammer, M.J., Young, A.W., Andrew, C., Travis, M.J., Williams, S.C.R., Phillips, M.L. (2003). A preferential increase in the extrastriate response to signals of danger. Neuroimage, 19, 1317-1328.
41. Abel. K.M., Pietura, K.K., Allin, M.P.G., David, A.S., Andrew, C., Williams, S.C.R., Phillips, M.L. (2003). Ketamine alters neural processing of facial emotion recognition in healthy men: an FMRI study. NeuroReport, 14, 387-91
42. Baker, D., Hunter, E., Lawrence, E., Medford, N., Sierra, M., Lambert, M., Phillips, M.L., David, A.S. (2003). Depersonalisation Disorder: clinical features of 204 cases. British Journal of Psychiatry, 182, 428-433.
43. Medford, N., Baker, D., Hunter, E., Sierra, M., Lawrence, E., Phillips, M.L., David, A.S. (2003). Chronic depersonalisation following illicit drug use: review of forty cases. Addictions, 182, 428-433.
44. Surguladze, S., Senior, C., Brebion, G., Travis, M.J., Young, A.W., Phillips, M.L. (2004). Recognition accuracy and response bias to happy and sad facial expressions in depressed patients. Neuropsychology, 18, 212-218.
45. Heining, M., Young, A.W., Ioannou, G., Andrew, C.M., Brammer, M.J., Gray, J.A., Phillips, M.L. (2003) Disgusting smells activate human anterior insula and ventral striatum. Annals of the New York Academy of Sciences, 1000, 380-384.
46. Williams, L.M., Liddell, B., Rathjen, J., Shevrin, H., Gray, J., Phillips, M.L., Young, A., Brown, K., Gordon, E. (2004). Mapping the time course of nonconscious and conscious perception of fear: an integration of central and peripheral measures. Human Brian Mapping, 21, 64-74.
47. Uher,R., Murphy,T., Brammer,M.J., Dalgleish, T., Phillips, M.L., Ng, V.G., Andrew, C.M., Williams, S.C.R., Campbell, I.C., Treasure, J. (2004). Functional neural correlates of eating disorders. Am J. Psychiatry, 161, 1238-1246.
48. Lawrence, N., Williams, A., Surguladze, S., Brammer, M.J., Williams, S.C.R., Phillips, M.L. (2004). Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar and major depression. Biological Psychiatry, 55, 578-587.
49. Phillips, M.L., Williams, L.M., Young, A.W., Russell, T., Herba, C.M., Heining, M., Andrew C., Bullmore, E.T., Brammer, M.J., Williams, S.C.R., Morgan, M.J., Gray, J.A. (2004). Differential neural responses to overt and covert presentations of facial expressions of fear and disgust. Neuroimage, 21,1484-1496.
50. Mataix-Cols, D., Cullen, S., Lawrence, N., Brammer, M.J., Zelaya, F., Andrew, C., Speckens, A., Phillips, M.L. (2004). Distinct neural correlates of washing, checking and hoarding symptom dimensions in obsessive-compulsive disorder. Arch. Gen. Psych, 61, 564-576.
51. Hunter, E.C.M., Phillips, M.L., Chalder, T., Sierra, M., David, A.S. (2003). Depersonalisation Disorder: A Cognitive - Behavioural Conceptualisation. Behavior Research and Therapy, 41, 1451-1467.
52. Williams, Leanne M., Das, Pritha , Harris, Anthony WF., Liddell, Belinda, Brammer, Michael J., Olivieri, Gloria, Skerrett, David, Phillips, Mary L., David, Anthony S., Peduto, Anthony, Gordon, Evian (2004). Dysregulation of arousal and limbic-prefrontal systems in schizophrenia. American Journal of Psychiatry, 161,480-489.
53. Surguladze, S., Brammer, M., Keedwell, P., Young, A., Andrew, C., Travis, M., Williams, S., Phillips, M.L. (2005). A differential pattern of neural response towards sad versus happy facial expressions in Major Depressive Disorder. Biological Psychiatry, 57, 201-209.
54. Medford N.C., Phillips M.L., Brierley B., Brammer M., Bullmore E.T., David A.S. (2005). Emotional Memory: Separating Content and Context. Psychiatry Research: Neuroimaging, 138, 247-258.
55. Kucharska-Pietura, K., David, A.S., Masiak, M., Phillips, M.L. (2005). Perception of Facial and Vocal Affect in Schizophrenic Patients in Early and Late Stages of Illness: evidence for a progressive deficit. Br. J. Psychiatry, 187, 523-528.
56. Kerr, N., Phillips, M.L. (2005). Emotional bias, anxiety and attentional deficits distinguishes bipolar from major depressive disorder. Br. J. Clinical Psychology, 44, 343-356.
57. Keedwell, P, Andrew, C, Williams, SCR, Brammer, M, Phillips, M.L. (2005). A dissociation of ventromedial prefrontal cortical response to sad versus happy stimuli in depressed and healthy individuals. Biol Psychiatry, 58, 495-503.
58. Keedwell, P, Andrew, C, Williams, SCR, Brammer, M, Phillips, M.L. (2005). Abnormal ventromedial prefrontal cortical and subcortical responses to happy stimuli are associated with anhedonia and state anxiety in major depressive disorder. Biological Psychiatry, 58, 843-853.
59. Uher, R., Murphy, T., Friederich, H.C., Dalgleish T., Brammer, M., Giampietro, V., Phillips, M.L., Andrew, C.M., Ng, V., Williams, S.C.R., Campbell, I.C., Treasure, J. (2005). Functional neuroanatomy of body shape perception in healthy and eating disordered women. Biological Psychiatry, 58, 990-997.
60. Hunter, E, Baker, D., Phillips, M.L., Sierra, M., David, A.S. (2005). Cognitive Behaviour Therapy for Depersonalisation Disorder: An Open Study. Behavior Research and Therapy, 43, 1121-1130.
61. Kronhaus, D.M., Lawrence, N., Williams, A.M., Frangou, S., Brammer, M.J., Williams, S.C.R., Andrew, C.A., Phillips, M.L. (2006). The ventral prefrontal cortex in bipolar disorder: distinguishing trait and depression-related abnormalities. Bipolar Disorders, 8, 28-39.
62. Lemche, E., Giampietro, V., Surgualdze, S., Amaro, E., Andrew, C., Williams, S.C.R., Simmons, A., Brammer, M.J., Lawrence, N., Maier, M., Ecker, C., Russell, T.A., Joraschky, P., Phillips, M.L. (2007 in press; EPub 11/2006). Human attachment security is mediated by the amygdala: evidence from combined fMRI and psychophysiological measures. Human Brain Mapping.
63. Surguladze, S, Russell, T, Kucharska-Pietura, K, Travis, MJ, Giampietro, V, David, AS, Phillips, ML. (2006). A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia. Biological Psychiatry, 60, 423-431.
64. Sierra M, Baker D, Medford M, Lawrence E, Patel M, Phillips ML, David AS. (2006). Lamotrigine as an Add-on Treatment for Depersonalization Disorder: A Retrospective Study of 32 Cases. Clin Neuropharmacol. 29, 253-8.
65. Lawrence NS, Wooderson S, Mataix-Cols D, David R, Speckens A, Phillips ML (2006). Decision Making and Set Shifting Impairments Are Associated With Distinct Symptom Dimensions in Obsessive–Compulsive Disorder. Neuropsychology, 20, 409-419.
66. Russell, T.A., Chu, E., Phillips, M.L. (2006). A pilot study to investigate the effectiveness of emotion recognition remediation in schizophrenia using the micro-expression training tool. Br. J. Clinical Psychology, 45, 579-583.
67. Herba C, Landau S, Russell T, Ecker C, Phillips M. (2006). The development of emotion processing in children: effects of age, emotion, and intensity. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47, 1098-1106.
68. Russell TA, Reynaud , Pietura K, Ecker C, Benson PJ, Zelaya F, Giampietro V, Brammer M, David A, Phillips ML. (2006).Neural responses to dynamic expressions of fear in schizophrenia. Neuropsychologia, 45, 107-123.
69. Medford N, Brierley B, Brammer M, Bullmore E, David AS, Phillips ML. (2006). Emotional memory in depersonalization disorder: an fMRI study. Psychiatry Research: Neuroimaging, 148, 93-102.
70. Deeley Q, Daly E, Surguladze S, Tunstall N, Mezey G, Beer D, Ambikapathy A, Robertson D, Giampietro V, Brammer MJ, Clarke A, Dowsett J, Fahy T, Phillips ML, Murphy DG. (2006). Facial emotion processing in criminal psychopathy . Preliminary functional magnetic resonance imaging study. British Journal of Psychiatry, 189, 533-539.
71. Sierra M, Senior C, Phillips ML, David AS (2006). Autonomic response in the perception of disgust and happiness in depersonalization disorder. Psychiatry Research, 145, 225– 231

72. Deeley Q, Daly E, Surguladze S, Page L, Toal F, Robertson D, Curran S, Giampietro V, Seal M, Brammer M, Andrew C, Murphy K, Phillips M, Murphy D. (2007). An event related fMRI study of facial emotion processing in Asperger Syndrome. Biological Psychiatry, 62(3):207-17
73. Lawrence NS, An SK, Mataix-Cols D, Ruths F, Speckens A, Phillips, M.L. (2007). Neural Responses to Facial Expressions of Disgust but not Fear are Modulated by Washing Symptoms in OCD. Biological Psychiatry, 61, 1072-1080.
74. Heining M, Herba C, Browning M, Benson PJ, Young AW, Phillips ML, Gray JA. (2007). Conscious and non-conscious discrimination of facial expressions. Visual Cognition, 15 (1), 36-47.
75. Yücel M, Harrison BJ, Wood SJ, Fornito A, Wellard RM, Pujol J, Clarke K Phillips ML, Kyrios M, Velakoulis D, Pantelis C. (2007).Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Archives of General Psychiatry, 64(8):946-55
76. Caseras X, Mataix-Cols D, An SK, Lawrence NS, Speckens A, Giampietro V, Brammer MJ, Phillips ML. (2007). Sex differences in neural responses to disgusting visual stimuli: Implications for disgust-related psychiatric disorders. Biological Psychiatry, 62(5):464-71
77. Lemche, E., Surguladze, S.A., Giampietro, V.P., Anilkumar, A.P., Brammer, M.J., Chitnis, X., Williams, S.C.R., Gasston, D., David, A.S., Phillips, M.L. (2007). Limbic and prefrontal responses to facial emotion expressions in depersonalization. NeuroReport, 18(5):473-7.
78. Ladouceur CD, Almeida JRC, Birmaher B, Axelson DA, Kupfer DJ, Phillips ML. (2008). Cortical and Subcortical GM Volume Differences in Healthy Bipolar Offspring: Potential Neuroanatomical Risk or Protective Markers in Bipolar Disorder. JAACAP, 47(5):532-539
79. Gilbert, AR, Mataix-Cols, D, Almeida, J, Lawrence, N, Nutche, J, Diwadkar, V, Keshavan, MS, Devlin, D, Phillips, ML. (2008). Brain Structure and Symptom Dimension Relationships in Obsessive-Compulsive Disorder: A Voxel-Based Morphometry Study. J. Affective Disorders, 109(1-2):117-26
80. Jollant, F, Lawrence, N, Giampietro, V, Brammer, MJ, Fullana, MA, Drapier, D, Philippe, C, Phillips, ML. (2008). Orbitofrontal cortex response to angry faces in men with histories of suicide attempts. American J. Psychiatry,165, 740-748
81. Deeley, Q, Daly, EM, Azuma, R, Surguladze, S, Giampietro, V, Brammer, MJ, Hallahan, B, Dunbar, R, Phillips, ML, Murphy, DGM. (2008). Changes in male brain responses to emotional faces from adolescence to middle age. Neuroimage 40(1):389-97
82. Mataix-Cols D, An SK, Lawrence N. Wooderson S, Speckens A, Giampietro V, Brammer MJ, Phillips ML. (2008,). Individual differences in disgust sensitivity modulate neural responses to aversive stimuli: Implications for anxiety disorders. E.J. Neuroscience. 27, 3050–3058
83. Mataix-Cols D, Lawrence NS, Wooderson S, Speckens A, Phillips ML (2008, in press).The Maudsley Obsessive-Compulsive Stimuli Set (MOCSS): Validation of a standardized paradigm for
symptom-specific provocation in Obsessive-Compulsive Disorder (OCD). Psychiatry Research
84. Herba, CM, Benson, P, Landau,S, Russell,T, Goodwin,C, Lemche,E, Santosh, P, Phillips M.L. (2008 in press). Impact of familiarity upon children’s developing facial expression recognition. JCCP
85. An SK, Mataix-Cols D, Lawrence NS, Wooderson S, Giampietro V, Speckens A, Brammer MJ, Phillips ML. (2008, in press). To discard or not to discard: The neural basis of hoarding symptoms in obsessive-compulsive disorder. Molecular Psychiatry.
86. Keedwell, P, Drapier, D, Surguladze, S, Giampietro, V, Brammer, MJ, Phillips, ML. (2008, in press/under final revision). Normalisation of differential visual cortical responses to sad and happy facial expressions following clinical improvement in MDD. J. Psychopharmacology
87. Surguladze S, Etkin A, Ecker C, Kalidindi S, Corsico A, Giampietro V, Lawrence N, Deeley Q, Murphy D, Kucharska-Pietura K, Russell TA, McGuffin P, Murray R, Phillips ML. (2008, in press). Genetic variation in the serotonin transporter modulates neural system-wide functional connectivity to both emotional and neutral faces. Genes, Brain and Behaviour.
88. Almeida, JRC, Akkal, D, Travis, MJ, Kerr, N, Banihashemi, L, Hassel, S, Kupfer, DJK, Phillips, ML. (2008, in press). Reduced gray matter volume in ventral prefrontal cortex but not amygdala in bipolar disorder: significant effects of gender and trait anxiety. Psychiatry Research: Neuroimaging
89. Hassel S, Ladouceur C, Kerr, N, Fissell K, Almeida J, Kupfer D J, Phillips ML. (2008, in press). Increased ventral striatal activity but not amygdala to mild happy faces in euthymic bipolar disorder: comorbid anxiety, illness duration and medication effects. Bipolar Disorders
90. Lemche E, Anilkumar A, Giampietro VP, Brammer MJ, Surguladze SA, Lawrence N, Gasston D, Chitnis X, David AS, Williams SCR, Sierra M, Joraschky P, Phillips ML. (2008, in press). Neural and autonomic responses to happy and sad facial expressions in depersonalization disorder.Br. J. Psychiatry.
91. Versace A, Almeida JCR , Hassel S, Walsh N, Novelli M, Klein C R, Kupfer DJ, Phillips ML. (2008, in press). Elevated left orbitofrontal white matter fractional anisotropy in bipolar adults revealed by tract-based spatial statistics. Archives of General Psychiatry

 

Peer-Reviewed Reviews and Editorials

 

92. Phillips, M.L. and David, A.S. (1994). Understanding the symptoms of schizophrenia using visual scan paths. British Journal of Psychiatry, 165, 673-675.
93. Phillips, M.L. and David, A.S. (1995). Facial processing in schizophrenia and delusional misidentification: cognitive neuropsychiatric approaches. Schizophrenia Research, 17, 109-114.
94. Senior, C., Phillips, M.L. and David, A.S. (1997). Psychiatry and the World-Wide -Web: some implications. Psychiatric Bulletin, 21, 12, 775-779.
95. Phillips, M.L., Senior, C., Fahy, T., David, A.S. (1998). Disgust - the forgotten emotion of psychiatry. British Journal of Psychiatry, 172, 373-375.
96. Senior C, Hunter E, Lambert MV, Medford NC, Sierra M, Phillips ML & David AS. (2001). Depersonalisation. The Psychologist, 14, 128-132.
97. Phillips, M.L., Sierra, M, Hunter, E., Lambert, M.V., Medford, N., Senior, C., David, A.S. (2001). A Depersonalisation Research Unit: progress report. Psychiatric Bulletin, 25, 105-108.
98. Phillips, M.L. (2003). Understanding the neurobiology of emotion perception: implications for psychiatry. British Journal of Psychiatry, 182, 190-192.
99. Phillips, M.L., Sierra-Siegert, M. (2003). Depersonalization disorder: a functional neuroanatomical perspective. Stress, 6,3, 9157-9165.
100. Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R.D (2003). The neurobiology of emotion perception I: towards an understanding of the neural basis of normal emotion perception Biological Psychiatry, 54, 504-514.
101. Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R.D (2003). The neurobiology of emotion perception II: implications for understanding the neural basis of emotion perceptual abnormalities in schizophrenia and affective disorders Biological Psychiatry, 54, 515-528.
102. Herba, C. and Phillips, M.L. (2004). Annotation: Development of facial expression recognition from childhood to adolescence: Behavioural and neurological perspectives. Journal of Child Psychology and Psychiatry and Allied Disciplines, 45, 1-14.
103. Phillips, M.L., Frank E. (2006) Redefining Bipolar Disorder – Toward DSM-V. American Journal of Psychiatry, 163, 7
104. Vieta E and Phillips ML (2007). Deconstructing bipolar disorder: a critical review of its diagnostic validity and a proposal for DSM-V and ICD-11. Schizophrenia Bulletin, 33(4):886-92
105. Phillips ML and Vieta E (2007). Identifying Biomarkers of Bipolar Disorder: Toward DSM-V. Schizophrenia Bulletin, 33(4):893-904
106. Phillips ML, Travis MJ, Fagiolini A, Kupfer DJ (2008). Medication Effects in Neuroimaging Studies of Bipolar Disorder. American Journal of Psychiatry, 165, 313-20
107. Phillips, ML, Ladouceur CD, Drevets, WC. The Neural Basis of Voluntary and Automatic Emotion Regulation: Implications for Understanding the Neurodevelopment of Bipolar Disorder. Molecular Psychiatry, (in press)

 

Invited reviews and editorials


108. Phillips, M.L. (2001). Neuroimaging of mood changes in healthy individuals. Perspectives in Depression, 9, 6-10.
109. Surguladze, S., Keedwell, P.K., Phillips, M.L. (2003). Neural systems underlying affective disorders. Advances in Psychiatric Treatments, 9. 446-455.
110. Phillips, M.L., Mataix-Cols, D. (2004). Patterns of neural response to emotive stimuli distinguish the different symptom dimensions of Obsessive Compulsive Disorder. CNS Spectrums, 9, 275-283.
111. Mataix-Cols, D., Phillips, M.L. Psychological and functional neuroimaging techniques in the study of anxiety disorders (2004). Psychiatry, 3, 22-26.
112. Phillips, M.L. (2004). Abnormal emotion processing in bipolar disorder: lessons from neuroimaging. Clinical Approaches in Bipolar Disorders, 3, 33-34.
113. Green. M. J., Phillips, M.L. (2004). Social threat perception and the evolution of paranoia. Neurosicence and Biobehavioural Reviews. Special issue on Anxiety and Neuroticism, 28,333-42.
114. Phillips, M.L. (2004). Facial processing deficits and social dysfunction: how are they related? Brain 127,1691-2.
115. Phillips, M.L., Hunter, E., Baker, D., Medford, N., Sierra-Siegert, M., David, A.S.(2005). Depersonalisation Disorder. Current Reviews – Medical Literature,16, 1-4
116. Phillips, M.L. (2006). The functional neuroanatomical basis of affective instability in bipolar disorder. Cognitive Neuropsychiatry,11, 233-249.
117. Phillips, M.L. (2007) The emerging role of neuroimaging in psychiatry: characterizing treatment-relevant endophenotypes. American Journal of Psychiatry, 164, 697-99
118. Keener, MT, Phillips, ML. (2007). Neuroimaging in Bipolar Disorder: A Review of Current Findings. Current Opinions in Psychiatry Reports. 9(6):512-20
119. Phillips, ML, Clark, L, Sahakian, BJ, Frank, E, Kupfer, DJ. (2008, in press). Neurocognition and neuroimaging in major depressive disorder and bipolar depression: implications for treatment and functional outcome. Foresight Project on Mental Capital and Mental Wellbeing.
120. Mataix-Cols, D., Phillips, M.L. (2007).Psychological and functional neuroimaging techniques in the study of anxiety disorders. Psychiatry, 6, 156-160.
121. Craddock, N, Antebi, D, Attenburrow, M-J, Bailey, A, Carson, A, Cowen, P, Craddock, B, Eagles, J, Ebmeier, K, Farmer, A, Fazel, S, Ferrier, N, Geddes, J, Goodwin, G, Harrison, P, Hawton, K, Hunter, S, Jacoby, R, Jones, I, Keedwell, P, Kerr, M, Mackin, P, McGuffin, P, McIntyre, DJ, McConville, P, Mountain, D, O’Donovan, MC, Owen, MJ, Oyebode, F, Phillips, M, Price, J, Shah, P,
Smith, DJ, Walters, J, Woodruff, P, Young, A, Zammit, S (2008, in press). Wake up call for British Psychiatry. British Journal of Psychiatry

Book chapters
122. Phillips, M.L. and David, A.S. (2000). Cognitive impairments as causes of positive symptoms in schizophrenia. In : Cognition in Schizophrenia (pp.210-228; eds. Sharma, T. and Harvey, P.). Oxford University Press, Oxford, UK.
123. Phillips, M.L. and Heining, M. (2002). Neural correlates of emotion perception: from faces to taste, pp. 196-208 in: Olfaction, Taste and Cognition. (eds. C. Rouby, B. Schaal, D. Dubois, R. Gervais, A. Holley). Cambridge University Press, Cambridge, UK.
124. Phillips, M.L. and Heining, M. (2002). Disgust and the self, pp. 13-24 in: Disorders of Body Image (eds. D.J. Castle and K. Phillips). Judy Wrightson, Wrightson Biomedical Publishing.
125. Phillips, M.L., Travis, M.J. (2003). Follow-up of patients recovering from the acute phase. In: Managing Acute Mania, Science Press Ltd.
126. Phillips, M.L. (2004). Functional neural abnormalities in schizophrenia and bipolar disorder: are they similar or different? pp. 193-204 in: Schizophrenia: Challenging the Orthodox. Eds. C McDonald, K. Schulze, R . Murray, P.Wright. Taylor & Francis Medical.
127. Phillips, M.L. (2005). Are subcortical regions too expansive in bipolar disorder. Pp. 37-50 in: Bipolar Disorder: the Upswing in Research and Treatment. Eds. C McDonald, K. Schulze, R . Murray, M. Tohen. Martin Dunitz.Taylor and Francis Group.
128. Herba CM, Hodgins S, Blackwood N, Kumari V, Naudts KH, Phillips ML (2006).The Neurobiology of psychopathy: A focus on emotion processing. In: Psychopathy: Theory, Research and Social Implications. Eds. H. Herve and J Yuille.Mahwah, New Jersey: Lawrence Erlbaum.
129. Heining, M and Phillips, ML. (2006). Role of the Insula in Smell and Disgust. In: Smell and the brain: Window to the mind. (Eds: W. Brewer, D. Castle, C. Pantelis) Cambridge University Press, in press.
130. Kupfer, DJ, Travis, MJ, Rosenstock, JB, Farchione, TR, Phillips, ML. (2008, in press) Thinking About Psychiatry. in, Oxford American Handbook of Psychiatry. 1st Edition. Eds. Kupfer, DJ, Horner, MS, Brent, DA, Lewis, DA, Reynolds, CF, Thase, ME, and Travis MJ. Oxford University Press, NY, USA
131. Surguladze, S, Keedwell, P, Phillips, ML. (2008, in press). The neuropsychology of mood disorders. In: Handbook of Neuropsychology of Mental Illness. Eds. S, Wood, N. Allen and C, Pantelis. Cambridge, UK. Cambridge University Press.
132. Holt, DJ, Phillips, ML. The Amygdala in Schizophrenia. (2008, in press/ under final revision) In: The Human Amygdala Ed. P.J. Whalen.

 

Other publications and book reviews


133. Phillips, M.L. (1993). Are patient notes sexist? Psychiatric Bulletin, 17, 7.
134. Young, AW, Sprengelmeyer, R., Phillips, ML and Calder, AJ (1997). Response to Rozin, P. Disgust faces, basal ganglia and obsessive-compulsive disorder: some strange brainfellows. Trends in Cognitive Sciences, 1, 9, 321-354.
135. Phillips, M.L. (1998). The Neuropsychology of Dreams. By Mark Solms. New Jersey: Lawrence Erlbaum. Brain, 121, pp.183-184.
136. Phillips, ML. (1998). Emotion in Motion. The Expressions of the Emotions in Man and Animals. By Charles Darwin. Introduction, Afterword and Commentaries by Paul Ekman. Harper Collins.The Emotional Brain. By Joseph LeDoux. Weidenfeld and Nicolson. Review for the Times Higher Education Supplement, August 7th, p. 22.