Stanley Center for the Innovative Treatment of Bipolar Disorder

THIRD INTERNATIONAL CONFERENCE 
ON BIPOLAR DISORDER



Introduction

Proceedings

Bipolar Conferences Home

Introduction to the Conference


Welcome/Overview

The first two International Conferences on Bipolar Disorder represented unique opportunities for researchers to share new information on the neurobiology and pathophysiology of bipolar illness, on psychobiological and psychosocial vulnerability factors, and on recent findings in epidemiology and clinical course. Perhaps in part as a result of the impetus provided by these two initial meetings, there has been a remarkable increase in funding, both public and private, for research on bipolar disorder. Although we had initially planned to wait until 2000 to convene the Third International Conference, the pace of research in this area has been so rapid as to warrant a revisiting of many research areas in 1999.

The conference presented information on the following topics: the relationship between bipolar disorder and suicide, neuroscience and neuroimaging, new approaches to the treatment of bipolar depression, an update on the epidemiology of bipolar illness, the influence of psychiatric and medical comorbidities on course and outcome, access to services and health policy, and new pharmacotherapies and ways of testing them. As in the past, the conference also featured "Ask the Experts" question and answer sessions.

Presentations during the first two days of the conference were technical and geared toward academic researchers and research-oriented clinicians. Psychiatrists, psychologists, neuroscientists and pharmacologists interested in bipolar disorder should find the content of the first phase of the conference useful in their research and practice.

The third day of the conference, included sessions on mental health services access and policy and on suicide as well as "Ask the Experts" sessions, geared toward audiences that include psychiatrists, psychologists, social workers, nurses, and other mental health care workers as well as individuals who have bipolar disorder and their families.

Conference Objectives:

At the close of the program, participants should be able to:

1. Identify psychosocial, genetic, and neurobiological risk factors related to bipolar disorder.

2. List techniques used for assessment and treatment of both classical and complicated or refractory cases of bipolar disorder.

3. Develop familiarity with new treatment approaches.

Course Directors

Ellen Frank, Ph.D.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Samuel A. Gershon, M.D.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

David J. Kupfer, M.D.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Alan G. Mallinger, M.D.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Michael E. Thase, M.D.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Faculty

Hagop S. Akiskal, M.D.
Veterans Administration Psychiatry Service
San Diego, California

Lori Altshuler, M.D.
University of California, Los Angeles
Los Angeles, California

Jules Angst, M.D.
Psychiatric University Hospital
Zurich, Switzerland

John A. Ascher, M.D.
Glaxo Wellcome Inc.
Research Triangle Park, North Carolina

Susan E. Bachus, Ph.D.
National Institute of Mental Health
Bethesda, Maryland

Ross J. Baldessarini, M.D.
Harvard Medical School
Boston, Massachusetts

Mark Bauer, M.D.
Brown University School of Medicine
Providence, Rhode Island

Steve S. Carter, Ph.D.
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Giovanni B. Cassano, M.D.
University of Pisa
Pisa, Italy

Paula J. Clayton, M.D.
University of Minnesota Medical School
Minneapolis, Minnesota

Daniel P. Cole, M.D.
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Jan A. Fawcett, M.D.
Rush Presbyterian St. Luke's Medical Center
Chicago, Illinois

Debra Frankel, L.S.W.
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Howard Goldman, M.D., Ph.D.
University of Maryland
Baltimore, Maryland

Robert M.A. Hirschfeld, M.D.
University of Texas Medical Branch
Galveston, Texas

Kay Jamison, Ph.D.
Johns Hopkins University School of Medicine
Baltimore, Maryland

Gabor I. Keitner, M.D.
Brown University School of Medicine
Providence, Rhode Island

Kelly J. Kelleher, M.D., M.P.H.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Athanasio Koukopoulos, M.D.
Centro Lucio Bini
Rome, Italy

Fouzia Laghrissi-Thode, M.D.
Novartis Pharmaceuticals Corporation
Basel, Switzerland

Peter M. Lewinsohn, Ph.D.
Oregon Research Institute
Eugene, Oregon

Husseini K. Manji, M.D., F.R.C.P.
Wayne State University School of Medicine
Detroit, Michigan

Kathleen R. Merikangas, Ph.D.
Yale University School of Medicine
New Haven, Connecticut

David Miklowitz, Ph.D.
University of Colorado
Boulder, Colorado

Gregory J. Moore, Ph.D.
Wayne State University School of Medicine
Detroit, Michigan

Paolo Lucio Morselli, M.D.
Instituto per la Ricerca e la Prevenzione della Depressione e dell' Ansia
Milan, Italy

Eric J. Nestler, M.D., Ph.D.
Yale University School of Medicine
New Haven, Connecticut

Atul Pande, M.D., F.R.C.P.C.
Parke-Davis Pharmaceutical Research
Ann Arbor, Michigan

Steven M. Paul, M.D.
Lilly Research Laboratories
Indianapolis, Indiana

William Z. Potter, M.D., Ph.D.
Lilly Research Laboratories
Indianapolis, Indiana

Noreen Reilly-Harrington, Ph.D.
Harvard Medical School
Boston, Massachusetts

Perry F. Renshaw, M.D., Ph.D.
Harvard Medical School
Boston, Massachusetts

Gary S. Sachs, M.D.
Harvard Medical School
Boston, Massachusetts

Sylvia G. Simpson, M.D.
Johns Hopkins University School of Medicine
Baltimore, Maryland

Jair C. Soares, M.D.
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Trisha Suppes, M.D., Ph.D.
The University of Texas Southwestern Medical Center
Dallas, Texas

Holly Swartz, M.D.
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Mauricio Tohen, M.D., Dr.P.H.
Eli Lilly and Company
Indianapolis, Indiana

Steven J. Verfaille, L.S.W.
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Michael Von Korff, Sc.D.
Group Health Cooperative of Puget Sound
Seattle, Washington

Robert M. Wettstein, M.D.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania

Lee K. Wolfson, M.Ed.
Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania

Deborah Yurgelun-Todd, Ph.D.
Harvard Medical School
Boston, Massachusetts

Disclosure Statement

In accord with the standards set forth by the ACCME, speakers have been asked to disclose any relationship to companies producing pharmaceuticals, medical equipment, or other relevant products or services which might be germane to the content of their lectures. The following speakers have disclosed the following information:

Hagop S. Akiskal, M.D.
Grant/Research Support Eli Lilly & Co.
Consultant

 

Abbott Laboratories
Janssen Pharmaceutica
Eli Lilly and Company
Speakers' Bureau

 

Abbott Laboratories
Glaxo Wellcome Inc.
Janssen Pharmaceutica
Eli Lilly and Company
SmithKline Beecham
Lori Altshuler, M.D.
Grant/Research Support Abbott Laboratories
Eli Lilly and Company
SmithKline Beecham
Consultant  Forest Laboratories, Inc.
Eli Lilly and Company
Speakers'Bureau Abbott Laboratories
Forest Laboratories, Inc.
Eli Lilly and Company
Pfizer Pharmaceuticals, Inc.
John Ascher, M.D.
Other Financial or Material Support Employee: Glaxo Wellcome Inc.
Susan E. Bachus, Ph.D.
Grant/Research Support National Alliance for Research on
Schizophrenia and Depression
Ellen Frank, Ph.D.
Grant/Research Support  Jewish Healthcare Foundation
Eli Lilly and Company
MacArthur Foundation
National Institute of Mental Health
Pfizer Pharmaceuticals, Inc.
Consultant  University of Pisa (Italy)
Samuel A. Gershon, M.D.
Consultant Angelini Pharmaceuticals
Astra Arcus AB
Astra Arcus USA
Bayer Corporation
Boehringer Ingelheim
Equinox Group
Foundation for Innovation in Medicine
Parexel
Reed Smith Shaw & McClay LLP and Arnold and Porter
G.D. Searle and Company
TEVA Pharmaceuticals
Worldwide Clinical Trials/Protodigm Ltd
Wyeth Ayerst Corporation
Robert M.A. Hirschfeld, M.D.
Grant/Research Support  Abbott Laboratories
Bristol-Myers Squibb
Glaxo Wellcome Inc.
Organon
Pfizer Pharmaceuticals, Inc.
Consultant  Abbott Laboratories
Bristol-Myers Squibb
Forest Laboratories, Inc.
Glaxo Wellcome Inc.
Eli Lilly and Company
Speakers' Bureau Organon
Pfizer Pharmaceuticals, Inc.
Sandoz
SmithKline Beecham
Stockholder Parke-Davis
Upjohn
Kay Jamison, Ph.D.
Speakers' Bureau  Abbott Laboratories
Solvay Pharmaceuticals
David J. Kupfer, M.D.
Grant/Research Support  Eli Lilly and Company
Consultant Forest Laboratories, Inc.
Speakers' Bureau Pfizer Pharmaceuticals, Inc.
Fouzia Laghrissi-Thode, M.D.
Other Financial or Material Support Employee: Novartis Pharma AG
Husseini K. Manji, M.D., FRCP
Grant/Research Support Janssen Pharmaceutica
Organon
Pharmacia & Upjohn
Consultant Janssen Pharmaceutica
Eli Lilly and Company
Pharmacia & Upjohn
Speakers' Bureau Janssen Pharmaceutica
Atul Pande, M.D., FRCP
Stockholder Parke-Davis
Warner-Lambert Company
Other Financial or Material Support Employee: Warner-Lambert Company
Steven M. Paul, M.D.
Other Financial or Material Support Employee: Eli Lilly and Company
William Z. Potter, M.D., Ph.D.
Other Financial or Material Support Employee: Eli Lilly and Company
Noreen Reilly-Harrington, Ph.D.
Speakers' Bureau Abbott Laboratories
Glaxo Wellcome Inc.
Perry F. Renshaw, M.D., Ph.D.
Grant/Research Support Bracco Diagnostics
General Electric Medical Systems
Interneuron
Eli Lilly and Company
Pfizer Pharmaceuticals, Inc.
Scios
SmithKline Beecham
Solvay Pharmaceuticals
Speakers' Bureau Bracco Diagnostics
Gary Sachs, M.D.
Grant/Research Support Abbott Laboratories
Forest Laboratories, Inc.
Glaxo Wellcome Inc.
Janssen Pharmaceutica
Scios
Grant/Research Support  Abbott Laboratories
Bristol-Myers Squibb
Glaxo Wellcome Inc.
Janssen Pharmaceutica
Eli Lilly and Company
Pfizer Pharmaceuticals, Inc.
Scios
SmithKline Beecham
Solvay Pharmaceuticals
Trisha Suppes, M.D., Ph.D.
Grant/Research Support Abbott Laboratories
Glaxo Wellcome Inc.
Janssen Pharmaceutica
Eli Lilly and Company
Novartis
Organon
Ortho-McNeil Pharmaceutical
SmithKline Beecham
Consultant CME
Glaxo Wellcome Inc.
Eli Lilly and Company
SCP Communications
Speakers' Bureau Abbott Laboratories
Eli Lilly and Company
Parke-Davis
Pfizer Pharmaceuticals, Inc.
Michael E. Thase, M.D.
Grant/Research Support Bristol-Myers Squibb
Eli Lilly & Co.
Forest Laboratories, Inc.
Glaxo Wellcome Inc./
Cerenex Pharmaceuticals
Lipha Pharmaceuticals, Inc.
Merck & Co.
Organon, Inc.
Pfizer Pharmaceuticals, Inc.
Pharmacia & Upjohn
Wyeth-Ayerst Laboratories
Consultant Bristol-Myers Squibb
Eli Lilly & Co.
Forest Laboratories, Inc.
Glaxo Wellcome Inc./
Cerenex Pharmaceuticals
Merck & Co. Organon, Inc.
Pfizer Pharmaceuticals, Inc.
Pharmacia & Upjohn
Wyeth-Ayerst Laboratories
Speakers' Bureau Bristol-Myers Squibb
Eli Lilly & Co.
Forest Laboratories, Inc.
Glaxo Wellcome Inc./
Cerenex Pharmaceuticals
Organon, Inc.
Parke-Davis
Pfizer Pharmaceuticals, Inc.
Pharmacia & Upjohn
SmithKline Beecham
Solvay Pharmaceuticals
Wyeth-Ayerst Laboratories
Mauricio Tohen, M.D., Dr.PH
Other Financial or Material Support Employee: Eli Lilly and Company
Steven J. Verfaille, L.S.W.
Stockholder  Eli Lilly and Company

The information presented at this CME program represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC Health System or Affiliates and University of Pittsburgh School of Medicine. Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

Acknowledgements

We gratefully acknowledge educational grants from Forest Laboratories, Inc., Glaxo Wellcome Inc., Janssen Pharmaceutica, Eli Lilly and Company, Novartis, Pfizer Pharmaceuticals, Inc., SmithKline Beecham, and Solvay Pharmaceuticals in support of this conference.

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