Table of Contents
ALTERNATIVES TO LINKAGE METHODS IN BIPOLAR DISORDER
Behaviors that Run in Families
Twin Concordance in Bipolar Disorder
Positional Cloning
Bipolar Affective Disorders Linked to DNA Markers on Chromosome 11 (Egeland et al. Nature, 1987;325:783-787)
Problems of Linkage Studies in Complex Diseases
Assumptions in Linkage Studies of Complex Diseases
Two Types of Complex Disease
Alternatives to Classic Linkage Studies
Affected Sib Pairs
Linkage and Association
Linkage and Association
Decay of Association for Recombination Fraction of 0.1
Decay of Association for Recombination Fractions of 0.01 and 0.001
Time (t) To Go Halfway to Equilibrium
Causes of Allelic Association
Population Stratification
Allelic Association: How Small An Effect Can Be Detected?
Approaches to Association Studies
Prime Candidate Genes
Serotonin Transporter and Mood Disorder
Human Serotonin Transporter Gene
Published Findings
Hypothesis 1: 5-HTT-VNTR Allele 12 More Common in BP cf Control
Hypothesis 2: 5-HTT-VNTR Allele 9 More Common in UP Versus Controls
Hypothesis 3:5-HTTLPR Deleted Allele More Common in BP/UP cf Controls
SERT and Affective Disorders
Trinucleotide Repeat Expansion Diseases
Repeat Expansion Detection (RED)Analysis
PPT Slide
PPT Slide
Requirements for a Genome-wide Search Using Allelic Association
Rapid Throughput
PPT Slide
PPT Slide
PPT Slide
Advantages of DNA Pooling
Conclusions
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Author: Computing Centre, JCCS
Home Page: http://www.wpic.pitt.edu/stanley/2ndbipconf/
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