LITHIUM MAINTENANCE THERAPY: EFFICACY-DOSE RELATIONSHIPS
Lithium Maintenance Therapy
Retrospective Studies that Found a Relationship Between Lithium Level and Response
Retrospective Studies that Did Not Find a Lithium Level-Response Relationship
Random Assignment Efficacy Studies
PPT Slide
Outcomes at the End of Protocol
Standard vs. Low Lithium Levels
Lithium Levels and Subsyndromal Symptoms (SS)
Subsyndromal Depression Leading to Relapse (n=33)
Hypomania Leading to Relapse (n=17)
Serum Levels and Adverse Effects
Standard vs. Low Lithium Levels Side Effects at Six Months
Risk Factors for Lithium Neurotoxicity at Therapeutic Serum Levels1
Dosing Methods
Change in Behavioral Ratings at Endpoint in Relationship to Final Serum Lithium Range (X+SD)*
Percentage of Manic Patients with 20% or Greater Improvement
Home Page: http://www.wpic.pitt.edu/stanley/2ndbipconf/